While only face-to-face methods have been used in the treatment of diseases in the past years, this situation has started to shift to the online environment, especially with the use of technology in health. Electronic patients (e-patients) have appeared as a result of the shift of patients to electronic media. An e- patient can be defined as a person who conducts research on the Internet for any of his ailments and solves this ailment by interviewing his physician through online platforms. In other words, e-patients prefer to meet online rather than face-to-face while using the health service. Especially with tele-medicine and mobile applications that have been widely used since the 2000s, e-patients have started to multiply. In this direction, it can be stated that this type of patient appears over time, therefore, there is also a transformation. With this transformation, which can be expressed as a transition from the physical patient to the e-patient, the communication between the physician and the patient has also changed. Therefore, in this study, it is aimed to examine the transition from physical patient to e-patient within the framework of communication. As a result of the literature review; It has been determined that there are differences between the physical patient and the e-patient, especially in the point of communication established, and these differences are given in a table. The negative consequences of the transformation from physical patient to e-patient, such as benefiting from health services more easily, eliminating the restrictions on accessing health services due to geographical distance, providing advantage to the patient in terms of time, establishing a cold mechanical communication, and limiting the physician's understanding of the patient's emotional state was found to be possible. It is necessary to increase the positive results of this transformation and reduce the negative consequences. In addition, this type of patient will increase even more, especially with the spread of remote health services. For this reason, it is important for today's physicians to adapt to these patients, future physicians to come knowing this patient type, and to gain communication skills that will create a disadvantage for patients in the electronic environment.