Körlüğün Biyolojik Ritimler Üzerine Etkisi ve Sirkadiyen Ritim Bozukluğunun Sonuçları

Subaşı, Merve; Batur, Muhammed; Atan, Yavuz Selim; Guzel Ozdemir, Pinar

doi:10.4274/tjo.galenos.2022.59296

Körlüğün Biyolojik Ritimler Üzerine Etkisi ve Sirkadiyen Ritim Bozukluğunun Sonuçları

Yavuz Selim ATAN, (Van Yüzüncü Yıl Üniversitesi, Tıp Fakültesi, Ruh Sağlığı ve Hastalıkları Anabilim Dalı, Van, TÜRKİYE)

Merve SUBAŞI, (Van Yüzüncü Yıl Üniversitesi, Tıp Fakültesi, Göz Hastalıkları Anabilim Dalı, Van, TÜRKİYE)

Pınar GÜZEL ÖZDEMİR, (Van Yüzüncü Yıl Üniversitesi, Tıp Fakültesi, Ruh Sağlığı ve Hastalıkları Anabilim Dalı, Van, TÜRKİYE)

Muhammed BATUR (Van Yüzüncü Yıl Üniversitesi, Tıp Fakültesi, Göz Hastalıkları Anabilim Dalı, Van, TÜRKİYE)

Türk Oftalmoloji Dergisi

5 4

Yıl: 2023 Cilt: 53 Sayı: 2 Sayfa Aralığı: 111 - 119 Metin Dili: Türkçe DOI: 10.4274/tjo.galenos.2022.59296 İndeks Tarihi: 31-05-2023

Körlüğün Biyolojik Ritimler Üzerine Etkisi ve Sirkadiyen Ritim Bozukluğunun Sonuçları

Öz:

Uyku uyanıklık siklusu, dikkat, vücut ısısı, bazı hormonların salınımı gibi çeşitli fizyolojik sistemler ve davranışlar sirkadiyen sistem adı verilen 24 saatlik bir döngüyle yönetilmektedir. Sirkadiyen ritmin düzenlenmesinde birçok dış uyarıcı olmakla birlikte en güçlü çevresel uyarıcı ışık-karanlık siklusudur. Körlüğü olan bireylerde ışık uyarısının alınamamasına bağlı olarak sirkadiyen sistemde bozulmalar meydana gelir. Bu sirkadiyen desenkronizasyona bağlı meydana gelen 24 saat olmayan uyku uyanıklık bozukluğunda uyku-uyanıklık bozukluklarına ek olarak duygudurum bozuklukları, sirkadiyen hormon düzeninin bozulmasına bağlı iştah ve sindirim problemleri meydana gelir. Klinik pratikte yeterince tanınmaması nedeniyle tanı alması sıklıkla geciken bu bozuklukta kişiler, sosyal ve akademik yaşamlarında çeşitli düzeylerde aksamalarla mücadele etmek zorunda kalır. Körlüğü olan çoğu birey sirkadiyen bozulmanın kendilerini körlükten daha çok etkilediğini bildirmiştir. Yirmi dört saat olmayan uyku uyanıklık bozukluğunun tedavisinde davranışçı yöntemlere ek olarak başlıca melatonin ve melatonin agonisti tasimelteon kullanılmaktadır. Kör bireylerde uyku düzeni, melatonin ve analoglarının kullanımı veya rezidüel görme varsa fototerapi ile daha normal hale getirilebildiğinden, bozuklukların tanınması aynı zamanda tedavi ile de ilgilidir. Bu nedenle oftalmologlar tarafından akılda tutulması gereken önemli bir konu da körlük yakınması ile başvuran bireylerde uyku sorunlarının da araştırılması ve buna yönelik tedavinin planlanmasıdır.

Anahtar Kelime:

The Effect of Blindness on Biological Rhythms and the Consequences of Circadian Rhythm Disorder

Öz:

Various physiological systems and behaviors such as the sleep-wake cycle, vigilance, body temperature, and the secretion of certain hormones are governed by a 24-hour cycle called the circadian system. While there are many external stimuli involved the regulation of circadian rhythm, the most powerful environmental stimulus is the daily light-dark cycle. Blind individuals with no light perception develop circadian desynchrony. This leads to non-24-hour sleep-wake rhythm disorder, which is associated with sleep-wake disorders, as well as mood disorders and loss of appetite and gastrointestinal disturbances due to disrupted circadian hormone regulation. As the diagnosis is often delayed because of under-recognition in clinical practice, patients must cope with varying degrees of social and academic dysfunction. Most blind individuals report that non-24-hour sleep-wake rhythm disorder affects them more than blindness. In the treatment of totally blind patients suffering from non-24-hour sleep-wake rhythm disorder, the first-line management is behavioral approaches. Drug therapy includes melatonin and the melatonin agonist tasimelteon. Diagnosing blind individuals’ sleep disorders is also relevant to treatment because they can be improved with the use of melatonin and its analogues or by phototherapy if they have residual vision. Therefore, assessing sleep problems and planning treatment accordingly for individuals presenting with blindness is an important issue for ophthalmologists to keep in mind.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Derleme Erişim Türü: Erişime Açık

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APA	Atan Y, Subaşı M, Guzel Ozdemir P, Batur M (2023). Körlüğün Biyolojik Ritimler Üzerine Etkisi ve Sirkadiyen Ritim Bozukluğunun Sonuçları. , 111 - 119. 10.4274/tjo.galenos.2022.59296
Chicago	Atan Yavuz Selim,Subaşı Merve,Guzel Ozdemir Pinar,Batur Muhammed Körlüğün Biyolojik Ritimler Üzerine Etkisi ve Sirkadiyen Ritim Bozukluğunun Sonuçları. (2023): 111 - 119. 10.4274/tjo.galenos.2022.59296
MLA	Atan Yavuz Selim,Subaşı Merve,Guzel Ozdemir Pinar,Batur Muhammed Körlüğün Biyolojik Ritimler Üzerine Etkisi ve Sirkadiyen Ritim Bozukluğunun Sonuçları. , 2023, ss.111 - 119. 10.4274/tjo.galenos.2022.59296
AMA	Atan Y,Subaşı M,Guzel Ozdemir P,Batur M Körlüğün Biyolojik Ritimler Üzerine Etkisi ve Sirkadiyen Ritim Bozukluğunun Sonuçları. . 2023; 111 - 119. 10.4274/tjo.galenos.2022.59296
Vancouver	Atan Y,Subaşı M,Guzel Ozdemir P,Batur M Körlüğün Biyolojik Ritimler Üzerine Etkisi ve Sirkadiyen Ritim Bozukluğunun Sonuçları. . 2023; 111 - 119. 10.4274/tjo.galenos.2022.59296
IEEE	Atan Y,Subaşı M,Guzel Ozdemir P,Batur M "Körlüğün Biyolojik Ritimler Üzerine Etkisi ve Sirkadiyen Ritim Bozukluğunun Sonuçları." , ss.111 - 119, 2023. 10.4274/tjo.galenos.2022.59296
ISNAD	Atan, Yavuz Selim vd. "Körlüğün Biyolojik Ritimler Üzerine Etkisi ve Sirkadiyen Ritim Bozukluğunun Sonuçları". (2023), 111-119. https://doi.org/10.4274/tjo.galenos.2022.59296

APA	Atan Y, Subaşı M, Guzel Ozdemir P, Batur M (2023). Körlüğün Biyolojik Ritimler Üzerine Etkisi ve Sirkadiyen Ritim Bozukluğunun Sonuçları. Türk Oftalmoloji Dergisi, 53(2), 111 - 119. 10.4274/tjo.galenos.2022.59296
Chicago	Atan Yavuz Selim,Subaşı Merve,Guzel Ozdemir Pinar,Batur Muhammed Körlüğün Biyolojik Ritimler Üzerine Etkisi ve Sirkadiyen Ritim Bozukluğunun Sonuçları. Türk Oftalmoloji Dergisi 53, no.2 (2023): 111 - 119. 10.4274/tjo.galenos.2022.59296
MLA	Atan Yavuz Selim,Subaşı Merve,Guzel Ozdemir Pinar,Batur Muhammed Körlüğün Biyolojik Ritimler Üzerine Etkisi ve Sirkadiyen Ritim Bozukluğunun Sonuçları. Türk Oftalmoloji Dergisi, vol.53, no.2, 2023, ss.111 - 119. 10.4274/tjo.galenos.2022.59296
AMA	Atan Y,Subaşı M,Guzel Ozdemir P,Batur M Körlüğün Biyolojik Ritimler Üzerine Etkisi ve Sirkadiyen Ritim Bozukluğunun Sonuçları. Türk Oftalmoloji Dergisi. 2023; 53(2): 111 - 119. 10.4274/tjo.galenos.2022.59296
Vancouver	Atan Y,Subaşı M,Guzel Ozdemir P,Batur M Körlüğün Biyolojik Ritimler Üzerine Etkisi ve Sirkadiyen Ritim Bozukluğunun Sonuçları. Türk Oftalmoloji Dergisi. 2023; 53(2): 111 - 119. 10.4274/tjo.galenos.2022.59296
IEEE	Atan Y,Subaşı M,Guzel Ozdemir P,Batur M "Körlüğün Biyolojik Ritimler Üzerine Etkisi ve Sirkadiyen Ritim Bozukluğunun Sonuçları." Türk Oftalmoloji Dergisi, 53, ss.111 - 119, 2023. 10.4274/tjo.galenos.2022.59296
ISNAD	Atan, Yavuz Selim vd. "Körlüğün Biyolojik Ritimler Üzerine Etkisi ve Sirkadiyen Ritim Bozukluğunun Sonuçları". Türk Oftalmoloji Dergisi 53/2 (2023), 111-119. https://doi.org/10.4274/tjo.galenos.2022.59296