Yıl: 2023 Cilt: 34 Sayı: 5 Sayfa Aralığı: 533 - 541 Metin Dili: İngilizce DOI: 10.5152/tjg.2023.21282 İndeks Tarihi: 01-06-2023

The Role of Endoplasmic Reticulum Stress in Gastroesophageal Reflux Disease Symptoms and Treatment

Öz:
Background: Gastroesophageal reflux disease is a common condition worldwide. There is no curative treatment for gastroesophageal reflux disease. Endoplasmic reticulum stress leads to the activation of the unfolded protein response and has an important role in inflammation. The aim is to determine the role of endoplasmic reticulum stress in the follow-up of individuals with gastroesophageal reflux disease and the temporal changes of endoplasmic reticulum stress markers with treatment. Methods: Twenty-four subjects in total were recruited prospectively, of whom 15 had nonerosive reflux disease. Two biopsies from 2 cm above the esophagogastric junction, 2 biopsies from gastric antrum mucosa, and 2 biopsies from gastric corpus mucosa were taken. Simultaneously, 2 tubes of venous blood samples were drawn from each individual (1 tube for studying the genetic markers and 1 tube for analyzing the CYP2C19 polymorphism). Results: The mean age was 42.3 ± 17.6 for women and 34.66 ± 11.2 for men. Pantoprazole, esomeprazole, rabeprazole, and lansoprazole preparations were used for treatment. There was no significant difference between tissue and blood samples for panel genes ATF-6, XBP-1, DDIT-3, DNAJC-10, and EIF-2-AK before treatment. There was a significant decrease in the level of ATF-6, XBP-1, DNAJC-9, EIF- 2-AK, and NF-2L-2 genes in blood after treatment. In the comparison of proton pump inhibitors, significant decreases in the expression of the ATF-6, XBP-1, and DNAJC-9 mRNAs were detected in blood from individuals after treatment. Conclusion: Endoplasmic reticulum stress can be for evaluating the clinical improvement and the effectiveness of treatment in gastro- esophageal reflux disease.
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Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA Kasap E, BURAN T, TORAMAN A, Hasdemir P, BALCAN E, AKTAN Ç, Korkmaz M (2023). The Role of Endoplasmic Reticulum Stress in Gastroesophageal Reflux Disease Symptoms and Treatment. , 533 - 541. 10.5152/tjg.2023.21282
Chicago Kasap Elmas,BURAN TAHİR,TORAMAN AYSUN,Hasdemir Pinar Solmaz,BALCAN Erdal,AKTAN Çağdaş,Korkmaz Mehmet The Role of Endoplasmic Reticulum Stress in Gastroesophageal Reflux Disease Symptoms and Treatment. (2023): 533 - 541. 10.5152/tjg.2023.21282
MLA Kasap Elmas,BURAN TAHİR,TORAMAN AYSUN,Hasdemir Pinar Solmaz,BALCAN Erdal,AKTAN Çağdaş,Korkmaz Mehmet The Role of Endoplasmic Reticulum Stress in Gastroesophageal Reflux Disease Symptoms and Treatment. , 2023, ss.533 - 541. 10.5152/tjg.2023.21282
AMA Kasap E,BURAN T,TORAMAN A,Hasdemir P,BALCAN E,AKTAN Ç,Korkmaz M The Role of Endoplasmic Reticulum Stress in Gastroesophageal Reflux Disease Symptoms and Treatment. . 2023; 533 - 541. 10.5152/tjg.2023.21282
Vancouver Kasap E,BURAN T,TORAMAN A,Hasdemir P,BALCAN E,AKTAN Ç,Korkmaz M The Role of Endoplasmic Reticulum Stress in Gastroesophageal Reflux Disease Symptoms and Treatment. . 2023; 533 - 541. 10.5152/tjg.2023.21282
IEEE Kasap E,BURAN T,TORAMAN A,Hasdemir P,BALCAN E,AKTAN Ç,Korkmaz M "The Role of Endoplasmic Reticulum Stress in Gastroesophageal Reflux Disease Symptoms and Treatment." , ss.533 - 541, 2023. 10.5152/tjg.2023.21282
ISNAD Kasap, Elmas vd. "The Role of Endoplasmic Reticulum Stress in Gastroesophageal Reflux Disease Symptoms and Treatment". (2023), 533-541. https://doi.org/10.5152/tjg.2023.21282
APA Kasap E, BURAN T, TORAMAN A, Hasdemir P, BALCAN E, AKTAN Ç, Korkmaz M (2023). The Role of Endoplasmic Reticulum Stress in Gastroesophageal Reflux Disease Symptoms and Treatment. Turkish Journal of Gastroenterology, 34(5), 533 - 541. 10.5152/tjg.2023.21282
Chicago Kasap Elmas,BURAN TAHİR,TORAMAN AYSUN,Hasdemir Pinar Solmaz,BALCAN Erdal,AKTAN Çağdaş,Korkmaz Mehmet The Role of Endoplasmic Reticulum Stress in Gastroesophageal Reflux Disease Symptoms and Treatment. Turkish Journal of Gastroenterology 34, no.5 (2023): 533 - 541. 10.5152/tjg.2023.21282
MLA Kasap Elmas,BURAN TAHİR,TORAMAN AYSUN,Hasdemir Pinar Solmaz,BALCAN Erdal,AKTAN Çağdaş,Korkmaz Mehmet The Role of Endoplasmic Reticulum Stress in Gastroesophageal Reflux Disease Symptoms and Treatment. Turkish Journal of Gastroenterology, vol.34, no.5, 2023, ss.533 - 541. 10.5152/tjg.2023.21282
AMA Kasap E,BURAN T,TORAMAN A,Hasdemir P,BALCAN E,AKTAN Ç,Korkmaz M The Role of Endoplasmic Reticulum Stress in Gastroesophageal Reflux Disease Symptoms and Treatment. Turkish Journal of Gastroenterology. 2023; 34(5): 533 - 541. 10.5152/tjg.2023.21282
Vancouver Kasap E,BURAN T,TORAMAN A,Hasdemir P,BALCAN E,AKTAN Ç,Korkmaz M The Role of Endoplasmic Reticulum Stress in Gastroesophageal Reflux Disease Symptoms and Treatment. Turkish Journal of Gastroenterology. 2023; 34(5): 533 - 541. 10.5152/tjg.2023.21282
IEEE Kasap E,BURAN T,TORAMAN A,Hasdemir P,BALCAN E,AKTAN Ç,Korkmaz M "The Role of Endoplasmic Reticulum Stress in Gastroesophageal Reflux Disease Symptoms and Treatment." Turkish Journal of Gastroenterology, 34, ss.533 - 541, 2023. 10.5152/tjg.2023.21282
ISNAD Kasap, Elmas vd. "The Role of Endoplasmic Reticulum Stress in Gastroesophageal Reflux Disease Symptoms and Treatment". Turkish Journal of Gastroenterology 34/5 (2023), 533-541. https://doi.org/10.5152/tjg.2023.21282