Change of Laboratory Findings of Acute Epstein-Barr Virus Infection According to Age Groups
Yıl: 2023 Cilt: 17 Sayı: 1 Sayfa Aralığı: 14 - 19 Metin Dili: İngilizce DOI: 10.5578/ced.20239903 İndeks Tarihi: 01-06-2023
Change of Laboratory Findings of Acute Epstein-Barr Virus Infection According to Age Groups
Öz: Objective: The aim of this study was to investigate the clinical and laboratory findings of patients diagnosed with acute Epstein-Barr virus (EBV) infection according to age groups. Material and Methods: Patients diagnosed with acute EBV infection were enrolled in this cross-sectional study. Results: Totally, 894 patients diagnosed as acute EBV infection were included in the study. Of them, 540 (60.5%) patients were males (male/female= 1.52). Median age of the patients was four years (57 days-18 years). Seropositivity rate increased statistically as age increased (47.9%, 73.8% and 87.2%, respectively). Seventy patients were admitted with clinical presentation of IM with a median age of seven years (3 years-18 years). Serum median hemoglobin, leukocyte, thrombocyte, mean platelet values were statistically signficifantly different according to age groups (for all p< 0.001). Leukocytosis was more commonly encountered in EBV infected children <6 years old of age compared to 6-15 years old age and >15 years old of age (29.3%, 17.1% and 7.7%, respectively, p< 0.001). Neutropenia was present in 157 (17.6%) patients. Mean platelet volume (MPV) increased statistically significantly as age increased (p< 0.001). MPV/platelet ratio increased significantly as age increased (p< 0.001). MPV/platelet ratio was higher in IM cases. High serum CRP was more common in <6 years old of age compared to 6-15 years old age and >15 years old of age [304 (49.4%), 204 (33.2%), 107 (17.4%), respectively, p= 0.04]. Conclusion: EBV infection causes different laboratory findings and clinical presentations according to age groups.
Anahtar Kelime: Akut Epstein-Barr Enfeksiyonunun Yaş Gruplarına Göre Laboratuvar Bulgularının Değişimi
Öz: Giriş: Bu çalışmada akut Epstein-Barr virüs (EBV) ile enfekte hastalarda yaş gruplarına göre klinik ve laboratuvar bulgularının araştırılması amaçlanmıştır. Gereç ve Yöntemler: Bu kesitsel çalışmaya akut EBV enfeksiyonu tanısı konan hastalar dahil edilmiştir. Bulgular: Çalışmaya akut EBV enfeksiyonu tanısı konan, ortanca yaşı dört (57 gün-18 yıl) olan 540 (%60.5)’ı erkek (erkek/kadın= 1.52) toplam 894 hasta dahil edilmiştir. Seropozitiflik oranı, yaş artıkça istatistiksel anlamlı olarak artmıştır (%47.9; %73.8 ve %87.2). Ortanca yaşı yedi (3-18 yaş) olan toplam 70 hasta enfeksiyöz mononükleoz kliniği ile başvurmuştur. Yaş gruplarına göre serum ortanca hemaoglobin, lökosit, trombosit, ortalama platelet hacmi değerleri anlamlı şekilde farklı bulunmuştur (p< 0.001). Lökositoz <6 yaş olan hastalarda, 6-15 yaş arası olanlara ve >15 yaş olanlara göre anlamlı şekilde daha sık saptanmıştır (%29.3 versus %17.1 ve %7.7 p< 0.001). Nötropeni 157 (%17.6) hastada saptanmıştır. Yaşla beraber ortalama platelet hacmi anlamlı olarak artmıştır (p< 0.001). MPV/platelet oranı yaş artıkça anlamlı olarak artmıştır (p< 0.001). MPV/platelet oranı enfeksiyöz mononükleoz kliniği olan hastalarda daha yüksek bulunmuştur. Serum C-reaktif protein yüksekliği <6 yaş hastalarda, 6-15 yaş arası hastalarda ve >15 yaş hastalarda daha sık saptanmıştır [304 (%49.4); 204 (%33.2); 107 (%17.4) p= 0.04]. Sonuç: EBV enfeksiyonu yaş gruplarına göre farklı klinik tablolara ve laboratuvar bulgularına neden olmaktadır.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | Oktay K, Karadag Oncel E, Kara A, Cengiz A, Ceyhan M (2023). Change of Laboratory Findings of Acute Epstein-Barr Virus Infection According to Age Groups. , 14 - 19. 10.5578/ced.20239903 |
| Chicago | Oktay Kamile Ötiken,Karadag Oncel Eda,Kara Ates,Cengiz Ali Bülent,Ceyhan Mehmet Change of Laboratory Findings of Acute Epstein-Barr Virus Infection According to Age Groups. (2023): 14 - 19. 10.5578/ced.20239903 |
| MLA | Oktay Kamile Ötiken,Karadag Oncel Eda,Kara Ates,Cengiz Ali Bülent,Ceyhan Mehmet Change of Laboratory Findings of Acute Epstein-Barr Virus Infection According to Age Groups. , 2023, ss.14 - 19. 10.5578/ced.20239903 |
| AMA | Oktay K,Karadag Oncel E,Kara A,Cengiz A,Ceyhan M Change of Laboratory Findings of Acute Epstein-Barr Virus Infection According to Age Groups. . 2023; 14 - 19. 10.5578/ced.20239903 |
| Vancouver | Oktay K,Karadag Oncel E,Kara A,Cengiz A,Ceyhan M Change of Laboratory Findings of Acute Epstein-Barr Virus Infection According to Age Groups. . 2023; 14 - 19. 10.5578/ced.20239903 |
| IEEE | Oktay K,Karadag Oncel E,Kara A,Cengiz A,Ceyhan M "Change of Laboratory Findings of Acute Epstein-Barr Virus Infection According to Age Groups." , ss.14 - 19, 2023. 10.5578/ced.20239903 |
| ISNAD | Oktay, Kamile Ötiken vd. "Change of Laboratory Findings of Acute Epstein-Barr Virus Infection According to Age Groups". (2023), 14-19. https://doi.org/10.5578/ced.20239903 |
| APA | Oktay K, Karadag Oncel E, Kara A, Cengiz A, Ceyhan M (2023). Change of Laboratory Findings of Acute Epstein-Barr Virus Infection According to Age Groups. Çocuk Enfeksiyon Dergisi, 17(1), 14 - 19. 10.5578/ced.20239903 |
| Chicago | Oktay Kamile Ötiken,Karadag Oncel Eda,Kara Ates,Cengiz Ali Bülent,Ceyhan Mehmet Change of Laboratory Findings of Acute Epstein-Barr Virus Infection According to Age Groups. Çocuk Enfeksiyon Dergisi 17, no.1 (2023): 14 - 19. 10.5578/ced.20239903 |
| MLA | Oktay Kamile Ötiken,Karadag Oncel Eda,Kara Ates,Cengiz Ali Bülent,Ceyhan Mehmet Change of Laboratory Findings of Acute Epstein-Barr Virus Infection According to Age Groups. Çocuk Enfeksiyon Dergisi, vol.17, no.1, 2023, ss.14 - 19. 10.5578/ced.20239903 |
| AMA | Oktay K,Karadag Oncel E,Kara A,Cengiz A,Ceyhan M Change of Laboratory Findings of Acute Epstein-Barr Virus Infection According to Age Groups. Çocuk Enfeksiyon Dergisi. 2023; 17(1): 14 - 19. 10.5578/ced.20239903 |
| Vancouver | Oktay K,Karadag Oncel E,Kara A,Cengiz A,Ceyhan M Change of Laboratory Findings of Acute Epstein-Barr Virus Infection According to Age Groups. Çocuk Enfeksiyon Dergisi. 2023; 17(1): 14 - 19. 10.5578/ced.20239903 |
| IEEE | Oktay K,Karadag Oncel E,Kara A,Cengiz A,Ceyhan M "Change of Laboratory Findings of Acute Epstein-Barr Virus Infection According to Age Groups." Çocuk Enfeksiyon Dergisi, 17, ss.14 - 19, 2023. 10.5578/ced.20239903 |
| ISNAD | Oktay, Kamile Ötiken vd. "Change of Laboratory Findings of Acute Epstein-Barr Virus Infection According to Age Groups". Çocuk Enfeksiyon Dergisi 17/1 (2023), 14-19. https://doi.org/10.5578/ced.20239903 |
