Molecular docking studies and biological activities of benzenesulfonamide-based thiourea and thiazolidinone derivatives targeting cholinesterases, α-glucosidase, and α-amylase enzymes

TASKIN-TOK, Tugba; Tuğrak Sakarya, Mehtap; Gul, Halise Inci; Yamali, Cem; Taslimi, Parham

doi:10.18596/jotcsa.1111172

Molecular docking studies and biological activities of benzenesulfonamide-based thiourea and thiazolidinone derivatives targeting cholinesterases, α-glucosidase, and α-amylase enzymes

Mehtap TUGRAK, (Gaziosmanpaşa Üniversitesi, Farmasötik Kimya Anabilim Dalı, Tokat, Türkiye)

Halise Inci Gul, (Atatürk Üniversitesi, Farmasötik Kimya Anabilim Dalı, Erzurum, Türkiye)

Cem Yamali, (Çukurova Üniversitesi, Temel Eczacılık Bilimleri Anabilim Dalı, Adana, Türkiye)

Parham Taslimi, (Bartın Üniversitesi, Fen Fakültesi, Biyoteknoloji Bölümü, Bartın, Türkiye)

TUĞBA TAŞKIN TOK (Gaziantep Üniversitesi, Kimya Bölümü, Gaziantep, Türkiye)

Journal of the Turkish Chemical Society, Section A: Chemistry

10 3

Yıl: 2023 Cilt: 10 Sayı: 2 Sayfa Aralığı: 385 - 424 Metin Dili: İngilizce DOI: 10.18596/jotcsa.1111172 İndeks Tarihi: 01-06-2023

Molecular docking studies and biological activities of benzenesulfonamide-based thiourea and thiazolidinone derivatives targeting cholinesterases, α-glucosidase, and α-amylase enzymes

Öz:

Alzheimer's disease (AD) and diabetes mellitus (DM) are related to abnormal changes in enzyme activity. While acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) are the primary targets in the treatment of Alzheimer's disease (AD), α-glucosidase (α-Gly) and α-amylase (α-Amy) enzymes are known for diabetes mellitus (DM). Here, benzenesulfonamide-based thiourea and thiazolidinone derivatives such as AChE, BChE, α-Gly, and α-Amy inhibitors were reported. The results revealed that compounds 1d and 2c showed promising AChE and BChE inhibition effects. Compound 2a was the most potent inhibitor against α-glycosidase and α-amylase, respectively. Molecular docking studies indicated that the lead compounds' binding energy values and molecular interactions were better than that of tacrine and acarbose. The most bioactive compounds may be considered potent leads for further studies.

Anahtar Kelime: Thiazolidinone Benzamide 'Alzheimer's disease Diabetes Mellitus Molecular Docking Synthesis

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Tuğrak Sakarya M, Gul H, Yamali C, Taslimi P, TASKIN-TOK T (2023). Molecular docking studies and biological activities of benzenesulfonamide-based thiourea and thiazolidinone derivatives targeting cholinesterases, α-glucosidase, and α-amylase enzymes. , 385 - 424. 10.18596/jotcsa.1111172
Chicago	Tuğrak Sakarya Mehtap,Gul Halise Inci,Yamali Cem,Taslimi Parham,TASKIN-TOK Tugba Molecular docking studies and biological activities of benzenesulfonamide-based thiourea and thiazolidinone derivatives targeting cholinesterases, α-glucosidase, and α-amylase enzymes. (2023): 385 - 424. 10.18596/jotcsa.1111172
MLA	Tuğrak Sakarya Mehtap,Gul Halise Inci,Yamali Cem,Taslimi Parham,TASKIN-TOK Tugba Molecular docking studies and biological activities of benzenesulfonamide-based thiourea and thiazolidinone derivatives targeting cholinesterases, α-glucosidase, and α-amylase enzymes. , 2023, ss.385 - 424. 10.18596/jotcsa.1111172
AMA	Tuğrak Sakarya M,Gul H,Yamali C,Taslimi P,TASKIN-TOK T Molecular docking studies and biological activities of benzenesulfonamide-based thiourea and thiazolidinone derivatives targeting cholinesterases, α-glucosidase, and α-amylase enzymes. . 2023; 385 - 424. 10.18596/jotcsa.1111172
Vancouver	Tuğrak Sakarya M,Gul H,Yamali C,Taslimi P,TASKIN-TOK T Molecular docking studies and biological activities of benzenesulfonamide-based thiourea and thiazolidinone derivatives targeting cholinesterases, α-glucosidase, and α-amylase enzymes. . 2023; 385 - 424. 10.18596/jotcsa.1111172
IEEE	Tuğrak Sakarya M,Gul H,Yamali C,Taslimi P,TASKIN-TOK T "Molecular docking studies and biological activities of benzenesulfonamide-based thiourea and thiazolidinone derivatives targeting cholinesterases, α-glucosidase, and α-amylase enzymes." , ss.385 - 424, 2023. 10.18596/jotcsa.1111172
ISNAD	Tuğrak Sakarya, Mehtap vd. "Molecular docking studies and biological activities of benzenesulfonamide-based thiourea and thiazolidinone derivatives targeting cholinesterases, α-glucosidase, and α-amylase enzymes". (2023), 385-424. https://doi.org/10.18596/jotcsa.1111172

APA	Tuğrak Sakarya M, Gul H, Yamali C, Taslimi P, TASKIN-TOK T (2023). Molecular docking studies and biological activities of benzenesulfonamide-based thiourea and thiazolidinone derivatives targeting cholinesterases, α-glucosidase, and α-amylase enzymes. Journal of the Turkish Chemical Society, Section A: Chemistry, 10(2), 385 - 424. 10.18596/jotcsa.1111172
Chicago	Tuğrak Sakarya Mehtap,Gul Halise Inci,Yamali Cem,Taslimi Parham,TASKIN-TOK Tugba Molecular docking studies and biological activities of benzenesulfonamide-based thiourea and thiazolidinone derivatives targeting cholinesterases, α-glucosidase, and α-amylase enzymes. Journal of the Turkish Chemical Society, Section A: Chemistry 10, no.2 (2023): 385 - 424. 10.18596/jotcsa.1111172
MLA	Tuğrak Sakarya Mehtap,Gul Halise Inci,Yamali Cem,Taslimi Parham,TASKIN-TOK Tugba Molecular docking studies and biological activities of benzenesulfonamide-based thiourea and thiazolidinone derivatives targeting cholinesterases, α-glucosidase, and α-amylase enzymes. Journal of the Turkish Chemical Society, Section A: Chemistry, vol.10, no.2, 2023, ss.385 - 424. 10.18596/jotcsa.1111172
AMA	Tuğrak Sakarya M,Gul H,Yamali C,Taslimi P,TASKIN-TOK T Molecular docking studies and biological activities of benzenesulfonamide-based thiourea and thiazolidinone derivatives targeting cholinesterases, α-glucosidase, and α-amylase enzymes. Journal of the Turkish Chemical Society, Section A: Chemistry. 2023; 10(2): 385 - 424. 10.18596/jotcsa.1111172
Vancouver	Tuğrak Sakarya M,Gul H,Yamali C,Taslimi P,TASKIN-TOK T Molecular docking studies and biological activities of benzenesulfonamide-based thiourea and thiazolidinone derivatives targeting cholinesterases, α-glucosidase, and α-amylase enzymes. Journal of the Turkish Chemical Society, Section A: Chemistry. 2023; 10(2): 385 - 424. 10.18596/jotcsa.1111172
IEEE	Tuğrak Sakarya M,Gul H,Yamali C,Taslimi P,TASKIN-TOK T "Molecular docking studies and biological activities of benzenesulfonamide-based thiourea and thiazolidinone derivatives targeting cholinesterases, α-glucosidase, and α-amylase enzymes." Journal of the Turkish Chemical Society, Section A: Chemistry, 10, ss.385 - 424, 2023. 10.18596/jotcsa.1111172
ISNAD	Tuğrak Sakarya, Mehtap vd. "Molecular docking studies and biological activities of benzenesulfonamide-based thiourea and thiazolidinone derivatives targeting cholinesterases, α-glucosidase, and α-amylase enzymes". Journal of the Turkish Chemical Society, Section A: Chemistry 10/2 (2023), 385-424. https://doi.org/10.18596/jotcsa.1111172