TY  - JOUR
TI  - Molecular docking studies and biological activities of benzenesulfonamide-based thiourea and thiazolidinone derivatives targeting cholinesterases, α-glucosidase, and α-amylase enzymes
AB  - Alzheimer's disease (AD) and diabetes mellitus (DM) are related to abnormal changes in enzyme activity. While acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) are the primary targets in the treatment of Alzheimer's disease (AD), α-glucosidase (α-Gly) and α-amylase (α-Amy) enzymes are known for diabetes mellitus (DM). Here, benzenesulfonamide-based thiourea and thiazolidinone derivatives such as AChE, BChE, α-Gly, and α-Amy inhibitors were reported. The results revealed that compounds 1d and 2c showed promising AChE and BChE inhibition effects. Compound 2a was the most potent inhibitor against α-glycosidase and α-amylase, respectively. Molecular docking studies indicated that the lead compounds' binding energy values and molecular interactions were better than that of tacrine and acarbose. The most bioactive compounds may be considered potent leads for further studies.
AU  - TASKIN-TOK, Tugba
AU  - Tuğrak Sakarya, Mehtap
AU  - Gul, Halise Inci
AU  - Yamali, Cem
AU  - Taslimi, Parham
DO  - 10.18596/jotcsa.1111172
PY  - 2023
JO  - Journal of the Turkish Chemical Society, Section A: Chemistry
VL  - 10
IS  - 2
SN  - 2149-0120
SP  - 385
EP  - 424
DB  - TRDizin
UR  - http://search/yayin/detay/1178186
ER  -