The Relationship of Wrong Laxative Use with Constipation and Eating Disorders in vitro: Effect on Healthy Colon Fibroblast
Yıl: 2023 Cilt: 14 Sayı: 2 Sayfa Aralığı: 235 - 240 Metin Dili: İngilizce DOI: 10.31067/acusaglik.1149104 İndeks Tarihi: 01-06-2023
The Relationship of Wrong Laxative Use with Constipation and Eating Disorders in vitro: Effect on Healthy Colon Fibroblast
Öz: Objective: It is estimated that the use of wrong laxatives will increase the probability of developing an eating disorder by affecting the disorder in eating behavior and the physiological disorder of digestion. Long-term use of laxatives is known by many to impair normal colonic function and producing laxative dependence. In our study, it was aimed to determine the effect of the Folliculj sennae plant, which is used for laxative and slimming purposes, on the CCD-18Co (healthy colon fibroblast) cell line. Materials and Methods: The effect of Folliculj sennae plant. Its antiproliferative effect on CCD-18Co cell line was determined by MTT test. Results: According to the concentrations used in the CCD-18Co cell line, the % viability activities were determined between 73 and 54 and the 50% inhibitory concentration value (IC50) was calculated as 47 mg/ml. Conclusion: It is thought that the Folliculj sennae plant, which is used as a laxative and has a negative effect on the CCD18-Co cell line, will make an important contribution by health professionals to raise the awareness of their patients about laxatives.
Anahtar Kelime: Yanlış Laksatif Kullanımının Konstipasyon ve Yeme Bozuklukları ile İlişkisi in vitro: Sağlıklı Kolon Epiteli Üzerine Etkisi
Öz: Amaç: Yanlış laksatif kullanımı, yeme davranışında düzensizliğe ve sindirimin fizyolojik düzensizliğine etki ederek bireylerde yeme bozukluğu gelişme olasılığını artıracağı tahmin edilmektedir. Laksatiflerin uzun süreli kullanımının birçok kişi tarafından normal kolonik işlevi bozduğu ve laksatif bağımlılığı ürettiği bilinmektedir. Çalışmamızda laksatif ve zayıflama amacı ile kullanılan Folliculj sennae (açlık otu) bitkisinin CCD-18Co (sağlıklı kolon fibroblast) hücre hattındaki etkisini belirlemek amaçlanmıştır. Materyal ve Yöntem: Folliculj sennae bitkisinin etkisi CCD-18Co hücre hattı üzerinde MTT testi ile antiproliferatif etkisi belirlenmiştir. Bulgular: CCD-18Co hücre hattında kullanılan konsantrasyonlara göre % canlılılık aktiviteleri 73 ve 54 arasında belirlenmiştir ve %50 baskılayıcı konsantrasyon değeri (IC50) 47 mg/ml olarak hesaplanmıştır. Sonuç: Laksatif olarak kullanılan ve CCD18-Co hücre hattı üzerinde olumsuz etkisine şahit olduğumuz Folliculj sennae bitkisinin sağlık profesyonelleri tarafından laksatifler konusunda hastalarını bilinçlendirmesi için önemli katkı sağlayacağı düşünülmektedir.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | KESKİNER A, DAL E (2023). The Relationship of Wrong Laxative Use with Constipation and Eating Disorders in vitro: Effect on Healthy Colon Fibroblast. , 235 - 240. 10.31067/acusaglik.1149104 |
| Chicago | KESKİNER Aybüke Afra,DAL EZGİ SİNEM The Relationship of Wrong Laxative Use with Constipation and Eating Disorders in vitro: Effect on Healthy Colon Fibroblast. (2023): 235 - 240. 10.31067/acusaglik.1149104 |
| MLA | KESKİNER Aybüke Afra,DAL EZGİ SİNEM The Relationship of Wrong Laxative Use with Constipation and Eating Disorders in vitro: Effect on Healthy Colon Fibroblast. , 2023, ss.235 - 240. 10.31067/acusaglik.1149104 |
| AMA | KESKİNER A,DAL E The Relationship of Wrong Laxative Use with Constipation and Eating Disorders in vitro: Effect on Healthy Colon Fibroblast. . 2023; 235 - 240. 10.31067/acusaglik.1149104 |
| Vancouver | KESKİNER A,DAL E The Relationship of Wrong Laxative Use with Constipation and Eating Disorders in vitro: Effect on Healthy Colon Fibroblast. . 2023; 235 - 240. 10.31067/acusaglik.1149104 |
| IEEE | KESKİNER A,DAL E "The Relationship of Wrong Laxative Use with Constipation and Eating Disorders in vitro: Effect on Healthy Colon Fibroblast." , ss.235 - 240, 2023. 10.31067/acusaglik.1149104 |
| ISNAD | KESKİNER, Aybüke Afra - DAL, EZGİ SİNEM. "The Relationship of Wrong Laxative Use with Constipation and Eating Disorders in vitro: Effect on Healthy Colon Fibroblast". (2023), 235-240. https://doi.org/10.31067/acusaglik.1149104 |
| APA | KESKİNER A, DAL E (2023). The Relationship of Wrong Laxative Use with Constipation and Eating Disorders in vitro: Effect on Healthy Colon Fibroblast. Acıbadem Üniversitesi Sağlık Bilimleri Dergisi, 14(2), 235 - 240. 10.31067/acusaglik.1149104 |
| Chicago | KESKİNER Aybüke Afra,DAL EZGİ SİNEM The Relationship of Wrong Laxative Use with Constipation and Eating Disorders in vitro: Effect on Healthy Colon Fibroblast. Acıbadem Üniversitesi Sağlık Bilimleri Dergisi 14, no.2 (2023): 235 - 240. 10.31067/acusaglik.1149104 |
| MLA | KESKİNER Aybüke Afra,DAL EZGİ SİNEM The Relationship of Wrong Laxative Use with Constipation and Eating Disorders in vitro: Effect on Healthy Colon Fibroblast. Acıbadem Üniversitesi Sağlık Bilimleri Dergisi, vol.14, no.2, 2023, ss.235 - 240. 10.31067/acusaglik.1149104 |
| AMA | KESKİNER A,DAL E The Relationship of Wrong Laxative Use with Constipation and Eating Disorders in vitro: Effect on Healthy Colon Fibroblast. Acıbadem Üniversitesi Sağlık Bilimleri Dergisi. 2023; 14(2): 235 - 240. 10.31067/acusaglik.1149104 |
| Vancouver | KESKİNER A,DAL E The Relationship of Wrong Laxative Use with Constipation and Eating Disorders in vitro: Effect on Healthy Colon Fibroblast. Acıbadem Üniversitesi Sağlık Bilimleri Dergisi. 2023; 14(2): 235 - 240. 10.31067/acusaglik.1149104 |
| IEEE | KESKİNER A,DAL E "The Relationship of Wrong Laxative Use with Constipation and Eating Disorders in vitro: Effect on Healthy Colon Fibroblast." Acıbadem Üniversitesi Sağlık Bilimleri Dergisi, 14, ss.235 - 240, 2023. 10.31067/acusaglik.1149104 |
| ISNAD | KESKİNER, Aybüke Afra - DAL, EZGİ SİNEM. "The Relationship of Wrong Laxative Use with Constipation and Eating Disorders in vitro: Effect on Healthy Colon Fibroblast". Acıbadem Üniversitesi Sağlık Bilimleri Dergisi 14/2 (2023), 235-240. https://doi.org/10.31067/acusaglik.1149104 |
