TY  - JOUR
TI  - Factors Affecting Survival in Retroperitoneal Sarcomas Treated with Upfront Surgery: A Real-World Study by Turkish Oncology Group
AB  - Retroperitoneal sarcomas (RPS) account for approximately 15% of all soft tissue sarcomas (STS) and encompass a heterogeneous group of tumors with limited multimodality treatment options. Surgical resection with negative margins remains the standard primary treatment for patients with localized RPS. In this multicenter study, we aimed to demonstrate the real-world data on factors affecting survival in RPS treated with upfront surgery. We included a total of 197 patients who underwent curative-intent resection of a primary non-metastatic RPS between 2000-2020 at ten experienced medical oncology departments in Turkey. The median follow-up was 33 months. The median age of patients was 53 years, 57.4% of patients were female. Univariate analysis revealed that; tumor size, grade, necrosis, resection margin status, were factors affecting recurrence-free survival (RFS) (p= 0.002, p= 0.044, p= 0,024, p= 0.003 respectively). Age, tumor size, stage, resection margin status were factors affecting overall survival (OS) (p= 0.038, p= 0.001, p= 0.032, p< 0.001, respectively). In multivariate analysis, tumor size and resection margin status were independent factors affecting RFS and OS (all p-values < 0.05). Our study demonstrated that tumor size, and resection margin status were the main factors affecting survival in resected RFS. In comparison, adjuvant chemotherapy (CT), radiotherapy (RT), or multimodality treatment did not show OS and RFS advantages. We believe that advances in the molecular characterization of these tumors might help clinicians to detect the best candidates for adjuvant therapies in RPS.
AU  - sezgin goksu, sema
AU  - Dogan, Mutlu
AU  - Turan, Merve
AU  - sen, erdem
AU  - atcı, muhammed mustafa
AU  - SAKİN, Abdullah
AU  - ÖN, SERCAN
AU  - Akın Telli, Tugba
AU  - SENGUL SAMANCI, NİLAY
AU  - Sariyar, Nisanur
AU  - OZER, MUHAMMET
AU  - ÇEVİK, GÖKÇEN TUĞBA
AU  - Akagunduz, Baran
AU  - Demir, Nazan
AU  - ayhan, murat
AU  - Kılıçkap, Saadettin
AU  - OZYURT, Neslihan
AU  - HAFIZOGLU, Emre
AU  - KARACIN, Cengiz
AU  - Göktaş Aydın, Sabin
DO  - 10.4999/uhod.215190
PY  - 2021
JO  - Uluslararası Hematoloji-Onkoloji Dergisi
VL  - 31
IS  - 2
SN  - 1306-133X
SP  - 92
EP  - 98
DB  - TRDizin
UR  - http://search/yayin/detay/1178384
ER  -