Epidemics are among the most dangerous and unavoidable disasters in human history than wars. The causes of epidemics are directly dependent on human action. It takes a lot of victims with a misbehavior that takes very little effort. A whole geography, even the world, has to exert power to stop the epidemic that has taken action. Conflicts, wars, people who are constantly traveling, lack of shelter, polluted environment and the world, wars and the exhausted societies they bring react instantly and activate the epidemic-outbreaks. It is as if this greed of greedy people who plunder the world and exploit the innocent is accompanied by viruses. In periods when laboratory techniques were not developed and viruses were not visible with the naked eye, epidemics, whether pagan or monotheistic societies, ‘Wrath of God’, ‘Hand of Nergal’, ‘Apollo’s anger’ or ‘Divine punishment’, ‘Divine manifestation’ seen and accepted differently. The causes of ancient epidemics were seen as mice, one of the smallest mammalian species. Although rats are physically small creatures, they have kept humans busy in the past due to their endless hunger and excessive reproduction. These little creatures, which fascinated people in ancient times, whose reproductive secret was tried to be solved, which were thought to cause famine because they even gnawed metal, from which heal- ing was expected from time to time, and which were sometimes hoped to foretell the future, were also seen as responsible for epidemics. However, the mouse is only a disease carrier and causes the epidemic to spread.