TY  - JOUR
TI  - National Multi-Center Observational Retrospective Study to Understand Treatment Patterns and Outcomes for Stage III Non-Small Cell Lung Cancer Patients in Turkey: Turkish Society for Radiation Oncology Study, STONE Trial
AB  - This study investigated treatment patterns and outcomes in patients with inoperable stage III non-small cell lung cancer (NSCLC) treated with radiotherapy (RT) in Turkey. We included 492 patients with stage III NSCLC in this multi-center retrospective study. Pa - tient demographics, clinical characteristics, and clinical treatment patterns from the time of the initial diagnosis to disease progression were recorded. Additionally, the prognostic factors predicting overall survival (OS) and progression-free survival (PFS) were analyzed. For the initial treatment, 429 patients (89.2%) received chemotherapy and RT, whereas 53 patients (10.8%) were treated only with RT. The first disease progression occurred in 288 patients (58.4%) at 9.3 months (median) after the initial treatment, and 64.6% re - ceived treatment after first progression. The second disease progression occurred in 30 patients, and 20 patients (66.7%) received treatment. Median OS and PFS were 27.0 months and 13.4 months, respectively. Age (p< 0.001), stage (p= 0.04), poor performance score (PS) (p= 0.03) and RT doses (p= 0.002) were independent predictors for OS and PFS in our multivariate analysis. Additional significant predictors for OS in the multivariate analysis were gender (p= 0.004), treatment period (0.02), and irradiation technique (p= 0.02). Disease progression occurred in nearly 58% of the patients, and one-third of these patients remained untreated during the disease progression. These findings indicate a need for additional treatment options in patients with unresectable stage III NSCLC with high-risk features, namely older age, stage IIIB disease, poor PS, and lower RT doses.
AU  - Onal, Cem
AU  - Umay, Cenk
AU  - Hurmuz, Pervin
AU  - Dagoglu, Nergiz
AU  - Ayşe Nur, Ayşe Nur
AU  - Akyürek, Serap
AU  - karahacioglu, eray
AU  - duru birgi, sumerya
AU  - yaprak, gokhan
AU  - Kaytan Saglam, Esra
AU  - Atalar, Banu
AU  - Yalman, Deniz
AU  - erpolat, petek
AU  - BERBER, TANJU
AU  - Guler, Ozan Cem
AU  - Sert, Fatma
AU  - KARABULUT GÜL, SULE
DO  - 10.4999/uhod.225876
PY  - 2022
JO  - Uluslararası Hematoloji-Onkoloji Dergisi
VL  - 32
IS  - 1
SN  - 1306-133X
SP  - 23
EP  - 34
DB  - TRDizin
UR  - http://search/yayin/detay/1178749
ER  -