Comparison of lupus nephritis and non-lupus nephritides in patients with systemic lupus erythematosus

ARICI, Mustafa; ERDEM, YUNUS; Duran, Emine; Ertenli, Ihsan; Saglam, Arzu; Bilgin, Emre; Kalyoncu, Umut; YILDIRIM, Tolga; Taghiyeva, Arzu; Üner, Meral; Özen, Seza

doi:10.4274/raed.galenos.2022.30592

Comparison of lupus nephritis and non-lupus nephritides in patients with systemic lupus erythematosus

Emine DURAN, (Hacettepe University, Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, Ankara, Turkey)

Emre BİLGİN, (Hacettepe University, Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, Ankara, Turkey)

Umut KALYONCU, (Hacettepe University, Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, Ankara, Turkey)

Ali İhsan ERTENLİ, (Hacettepe University, Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, Ankara, Turkey)

Tolga YILDIRIM, (Hacettepe University, Faculty of Medicine, Department of Internal Medicine, Division of Nephrology, Ankara, Turkey)

Mustafa ARICI, (Hacettepe University, Faculty of Medicine, Department of Internal Medicine, Division of Nephrology, Ankara, Turkey)

Yunus ERDEM, (Hacettepe University, Faculty of Medicine, Department of Internal Medicine, Division of Nephrology, Ankara, Turkey)

Arzu TAGHİYEVA, (Hacettepe University, Faculty of Medicine, Department of Internal Medicine, Ankara, Turkey)

Arzu AYHAN, (Hacettepe University, Faculty of Medicine, Department of Pathology, Ankara, Turkey)

Meral ÜNER, (Hacettepe University, Faculty of Medicine, Department of Pathology, Ankara, Turkey)

Seza ÖZEN, (Hacettepe University, Faculty of Medicine, Department of Pediatrics, Division of Rheumatology, Ankara, Turkey)

Diğer Yazarlar

Ulusal Romatoloji Dergisi

3 2

Yıl: 2023 Cilt: 15 Sayı: 1 Sayfa Aralığı: 18 - 24 Metin Dili: İngilizce DOI: 10.4274/raed.galenos.2022.30592 İndeks Tarihi: 02-06-2023

Comparison of lupus nephritis and non-lupus nephritides in patients with systemic lupus erythematosus

Öz:

Objective: Kidney biopsy may unusually show non-lupus nephritis (LN) causes in patients with systemic lupus erythematosus (SLE). This study aimed to reveal the causes of non-LN and to compare the clinical and laboratory features of LN and non-lupus renal disease in patients with SLE. Methods: Patients with SLE followed between 2014 and 2020 at Hacettepe University Hospitals and who had kidney biopsy were the subject of the study. One hundred thirty four patients’ kidney biopsies were evaluated retrospectively and grouped as LN and non-LN. Clinical characteristics, laboratory values at the time of kidney biopsy, and renal outcome were recorded. Results: Of 134 (107 females, 27 males) patients, 116 (86.6%) were in the LN group, and 18 (13.4%) were in the non-LN group. The most common diagnosis was focal segmental glomerulosclerosis (n=6) in the non-LN group. The median (interquartile range) biopsy age of LN patients was young [21 (17.7) vs. 36.5 (17), p<0.001], and high titer antinuclear antibody positivity over 1/320 at SLE diagnosis was more frequent in this group (50.9% vs 22.2%, p=0.02). Non-renal SLE involvement was similar in both groups. Anti-dsDNA positivity, low C3- 4, and presence of active urinary sediment were significantly higher in LN patients, while serum creatinine, albumin, and proteinuria were not different between the groups at the time of kidney biopsy. Additionally, median renal SLEDAI was more elevated in LN patients. Conclusion: Anti-dsDNA positivity, low C3-C4, active urinary sediment, and high renal SLEDAI scores may give us some clues regarding renal disease in patients with SLE. However, it should be kept in mind that these serological abnormalities may also occur in non-lupus renal disease.

Anahtar Kelime:

Sistemik lupus eritematozuslu hastalarda lupus nefriti ve lupus dışı nefritlerin karşılaştırılması

Öz:

Amaç: Böbrek biyopsisi, nadiren de olsa sistemik lupus eritematozus (SLE) hastalarında lupus nefrit (LN) dışı nedenleri gösterebilir. Bu çalışmada, SLE hastalarında lupus dışı nefrit nedenlerinin ortaya çıkarılması ve LN ile LN dışı renal hastalığın klinik ve laboratuvar özelliklerinin karşılaştırılması amaçlandı. Yöntem: 2014-2020 yılları arasında Hacettepe Üniversitesi Tıp Fakültesi Hastaneleri’nde takip edilen ve böbrek biyopsisi yapılan SLE’li hastalar çalışmaya alındı. Yüz otuz dört hastanın böbrek biyopsisi retrospektif olarak değerlendirildi ve hastalar LN ve LN dışı renal hastalık olarak gruplandırıldı. Hastaların klinik özellikleri, böbrek biyopsisi sırasındaki laboratuvar değerleri ve renal son durumları hastane tıbbi kayıtlarından elde edildi. Bulgular: Yüz otuz dört (107 kadın, 27 erkek) hastanın 116’sı (%86,6) LN grubunda, 18’i (%13,4) LN olmayan gruptaydı. LN olmayan grupta en sık tanı fokal segmental glomerüloskleroz (n=6) idi. LN hastalarının medyan (çeyrekler açıklığı) biyopsi yaşı daha genç [21 (17,7) vs. 36,5 (17), p<0,001] olup SLE tanısında 1/320’nin üzerinde yüksek titre antinükleer antikor pozitifliği bu grupta daha sıktı (%50,9 vs. %22,2, p=0,02). Böbrek dışı SLE tutulumu her iki grupta da benzerdi. Renal biyopsi sırasında LN hastalarında anti-dsDNA pozitifliği, düşük C3-4 ve aktif idrar sedimenti varlığı anlamlı olarak yüksek iken serum kreatinin, albümin ve proteinüri gruplar arasında farklı değildi. Ayrıca medyan renal SLEDAI skoru LN hastalarında daha yüksekti. Sonuç: Anti-dsDNA pozitifliği, düşük C3-C4, aktif idrar sedimenti ve yüksek renal SLEDAI skorları, SLE hastalarında böbrek hastalığı ile ilgili bize bazı ipuçları verebilir. Ancak bu serolojik anormalliklerin lupus dışı böbrek hastalığında da ortaya çıkabileceği unutulmamalıdır.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Duran E, Bilgin E, Kalyoncu U, Ertenli I, YILDIRIM T, ARICI M, ERDEM Y, Taghiyeva A, Saglam A, Üner M, Özen S (2023). Comparison of lupus nephritis and non-lupus nephritides in patients with systemic lupus erythematosus. , 18 - 24. 10.4274/raed.galenos.2022.30592
Chicago	Duran Emine,Bilgin Emre,Kalyoncu Umut,Ertenli Ihsan,YILDIRIM Tolga,ARICI Mustafa,ERDEM YUNUS,Taghiyeva Arzu,Saglam Arzu,Üner Meral,Özen Seza Comparison of lupus nephritis and non-lupus nephritides in patients with systemic lupus erythematosus. (2023): 18 - 24. 10.4274/raed.galenos.2022.30592
MLA	Duran Emine,Bilgin Emre,Kalyoncu Umut,Ertenli Ihsan,YILDIRIM Tolga,ARICI Mustafa,ERDEM YUNUS,Taghiyeva Arzu,Saglam Arzu,Üner Meral,Özen Seza Comparison of lupus nephritis and non-lupus nephritides in patients with systemic lupus erythematosus. , 2023, ss.18 - 24. 10.4274/raed.galenos.2022.30592
AMA	Duran E,Bilgin E,Kalyoncu U,Ertenli I,YILDIRIM T,ARICI M,ERDEM Y,Taghiyeva A,Saglam A,Üner M,Özen S Comparison of lupus nephritis and non-lupus nephritides in patients with systemic lupus erythematosus. . 2023; 18 - 24. 10.4274/raed.galenos.2022.30592
Vancouver	Duran E,Bilgin E,Kalyoncu U,Ertenli I,YILDIRIM T,ARICI M,ERDEM Y,Taghiyeva A,Saglam A,Üner M,Özen S Comparison of lupus nephritis and non-lupus nephritides in patients with systemic lupus erythematosus. . 2023; 18 - 24. 10.4274/raed.galenos.2022.30592
IEEE	Duran E,Bilgin E,Kalyoncu U,Ertenli I,YILDIRIM T,ARICI M,ERDEM Y,Taghiyeva A,Saglam A,Üner M,Özen S "Comparison of lupus nephritis and non-lupus nephritides in patients with systemic lupus erythematosus." , ss.18 - 24, 2023. 10.4274/raed.galenos.2022.30592
ISNAD	Duran, Emine vd. "Comparison of lupus nephritis and non-lupus nephritides in patients with systemic lupus erythematosus". (2023), 18-24. https://doi.org/10.4274/raed.galenos.2022.30592

APA	Duran E, Bilgin E, Kalyoncu U, Ertenli I, YILDIRIM T, ARICI M, ERDEM Y, Taghiyeva A, Saglam A, Üner M, Özen S (2023). Comparison of lupus nephritis and non-lupus nephritides in patients with systemic lupus erythematosus. Ulusal Romatoloji Dergisi, 15(1), 18 - 24. 10.4274/raed.galenos.2022.30592
Chicago	Duran Emine,Bilgin Emre,Kalyoncu Umut,Ertenli Ihsan,YILDIRIM Tolga,ARICI Mustafa,ERDEM YUNUS,Taghiyeva Arzu,Saglam Arzu,Üner Meral,Özen Seza Comparison of lupus nephritis and non-lupus nephritides in patients with systemic lupus erythematosus. Ulusal Romatoloji Dergisi 15, no.1 (2023): 18 - 24. 10.4274/raed.galenos.2022.30592
MLA	Duran Emine,Bilgin Emre,Kalyoncu Umut,Ertenli Ihsan,YILDIRIM Tolga,ARICI Mustafa,ERDEM YUNUS,Taghiyeva Arzu,Saglam Arzu,Üner Meral,Özen Seza Comparison of lupus nephritis and non-lupus nephritides in patients with systemic lupus erythematosus. Ulusal Romatoloji Dergisi, vol.15, no.1, 2023, ss.18 - 24. 10.4274/raed.galenos.2022.30592
AMA	Duran E,Bilgin E,Kalyoncu U,Ertenli I,YILDIRIM T,ARICI M,ERDEM Y,Taghiyeva A,Saglam A,Üner M,Özen S Comparison of lupus nephritis and non-lupus nephritides in patients with systemic lupus erythematosus. Ulusal Romatoloji Dergisi. 2023; 15(1): 18 - 24. 10.4274/raed.galenos.2022.30592
Vancouver	Duran E,Bilgin E,Kalyoncu U,Ertenli I,YILDIRIM T,ARICI M,ERDEM Y,Taghiyeva A,Saglam A,Üner M,Özen S Comparison of lupus nephritis and non-lupus nephritides in patients with systemic lupus erythematosus. Ulusal Romatoloji Dergisi. 2023; 15(1): 18 - 24. 10.4274/raed.galenos.2022.30592
IEEE	Duran E,Bilgin E,Kalyoncu U,Ertenli I,YILDIRIM T,ARICI M,ERDEM Y,Taghiyeva A,Saglam A,Üner M,Özen S "Comparison of lupus nephritis and non-lupus nephritides in patients with systemic lupus erythematosus." Ulusal Romatoloji Dergisi, 15, ss.18 - 24, 2023. 10.4274/raed.galenos.2022.30592
ISNAD	Duran, Emine vd. "Comparison of lupus nephritis and non-lupus nephritides in patients with systemic lupus erythematosus". Ulusal Romatoloji Dergisi 15/1 (2023), 18-24. https://doi.org/10.4274/raed.galenos.2022.30592