Osteoporoz Epigenetiği

tural, sengul; TEKCAN, ESRA; Tural, Ercan

doi:10.4274/tod.galenos.2022.80148

Osteoporoz Epigenetiği

Şengül TURAL, (Ondokuz Mayıs Üniversitesi, Tıp Fakültesi, Tıbbi Biyoloji Anabilim Dalı, Samsun, TÜRKİYE)

Esra TEKCAN, (Ondokuz Mayıs Üniverstitesi, Tıp Fakültesi, Merkez Laboratuvarı, Samsun, TÜRKİYE)

Ercan TURAL (Ondokuz Mayıs Üniversitesi, Sağlık Bilimleri Fakültesi, Fizyoterapi ve Rehabilitasyon Anabilim Dalı, Samsun, TÜRKİYE)

Türk Osteoporoz Dergisi

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Yıl: 2023 Cilt: 29 Sayı: 1 Sayfa Aralığı: 1 - 9 Metin Dili: Türkçe DOI: 10.4274/tod.galenos.2022.80148 İndeks Tarihi: 03-06-2023

Osteoporoz Epigenetiği

Öz:

Osteoporoz (OP), düşük kemik kütlesi ve kemik dokusunun mikromimarisinin bozulması, bunun sonucunda kemik kırılganlığında ve kırılma eğiliminde artış ile karakterize sistemik bir hastalıktır. Prenatal dönem dahil olmak üzere yaşamın erken dönemindeki çevresel faktörler, yaşamın sonraki dönemlerinde kemik kütlesini ve dolayısıyla OP riskini etkileyebilir. Epigenetik esas olarak transkripsiyon sonrası düzenleyici bir rol oynar ve biyolojik sinyal düzenleyici yolakta önemli işlevlere sahiptir. Epigenetik mekanizmalar, kemik oluşumu ve kemik erimesinden sorumlu olan kemik hücrelerinin, osteoblastların ve osteoklastların farklılaşmasında önemli rol oynar. Birkaç çalışma, OP’lu hastalarda bazı farklı şekilde metillenmiş genler göstermiştir. Anormal epigenetik düzenleme, OP gibi bir dizi kemik metabolizması ile ilgili hastalığa yol açabilir. Bunlar, osteoblast farklılaşmasının önemli bir düzenleyicisi olan Wnt yoluna ait genleri ve iskeletin gelişiminde rol oynayan diğer genleri içerir. Benzer şekilde, bu hastalarda bazı MikroRNA’lar farklı şekilde eksprese edilebilir. Ancak, bu sonuçların diğer kohortlarda tekrarlanması önerilmektedir. Genomdan farklı olarak, epigenom hücreye özgüdür ve yaşlanma ve çevresel faktörlerle değişir. Bu nedenle, epigenetik epidemiyoloji çalışmalarının tasarımı ve yorumlanması birtakım pratik zorluklar doğurmaktadır. Epigenetik mekanizmalar, kemik oluşumu ve kemik erimesinden sorumlu olan kemik hücrelerinin, osteoblastların ve osteoklastların farklılaşmasında önemli rol oynamaktadır.

Anahtar Kelime:

Epigenetics of Osteoporosis

Öz:

Osteoporosis (OP) is a systemic disease characterized by low bone mass and deterioration of the microarchitecture of bone tissue, resulting in increased bone fragility and fracture tendency. Environmental factors early in life, including the prenatal period, can affect bone mass later in life and thus the risk of OP. Epigenetics mainly plays a post-transcriptional regulatory role and has important functions in the biological signal- regulatory pathway. Epigenetic mechanisms play an important role in the differentiation of bone cells, osteoblasts, and osteoclasts, which are responsible for bone formation and bone resorption. Several studies have shown some differentially methylated genes in patients with OP. The abnormal epigenetic regulation can lead to a number of bone metabolism-related diseases such as OP. These include genes for theWnt pathway, an important regulator of osteoblast differentiation, and other genes involved in skeletal development. Similarly, some MicroRNA’s may be differentially expressed in these patients. However, it is recommended that these results should be replicated in other cohorts. Unlike the genome, the epigenome is cell-specific and changes with aging and environmental factors. Therefore, the design and interpretation of epigenetic epidemiology studies pose a number of practical challenges. Epigenetic mechanisms play an important role in the differentiation of bone cells, osteoblasts, and osteoclasts, which are responsible for bone formation and bone resorption.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Derleme Erişim Türü: Erişime Açık

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APA	tural s, TEKCAN E, Tural E (2023). Osteoporoz Epigenetiği. , 1 - 9. 10.4274/tod.galenos.2022.80148
Chicago	tural sengul,TEKCAN ESRA,Tural Ercan Osteoporoz Epigenetiği. (2023): 1 - 9. 10.4274/tod.galenos.2022.80148
MLA	tural sengul,TEKCAN ESRA,Tural Ercan Osteoporoz Epigenetiği. , 2023, ss.1 - 9. 10.4274/tod.galenos.2022.80148
AMA	tural s,TEKCAN E,Tural E Osteoporoz Epigenetiği. . 2023; 1 - 9. 10.4274/tod.galenos.2022.80148
Vancouver	tural s,TEKCAN E,Tural E Osteoporoz Epigenetiği. . 2023; 1 - 9. 10.4274/tod.galenos.2022.80148
IEEE	tural s,TEKCAN E,Tural E "Osteoporoz Epigenetiği." , ss.1 - 9, 2023. 10.4274/tod.galenos.2022.80148
ISNAD	tural, sengul vd. "Osteoporoz Epigenetiği". (2023), 1-9. https://doi.org/10.4274/tod.galenos.2022.80148

APA	tural s, TEKCAN E, Tural E (2023). Osteoporoz Epigenetiği. Türk Osteoporoz Dergisi, 29(1), 1 - 9. 10.4274/tod.galenos.2022.80148
Chicago	tural sengul,TEKCAN ESRA,Tural Ercan Osteoporoz Epigenetiği. Türk Osteoporoz Dergisi 29, no.1 (2023): 1 - 9. 10.4274/tod.galenos.2022.80148
MLA	tural sengul,TEKCAN ESRA,Tural Ercan Osteoporoz Epigenetiği. Türk Osteoporoz Dergisi, vol.29, no.1, 2023, ss.1 - 9. 10.4274/tod.galenos.2022.80148
AMA	tural s,TEKCAN E,Tural E Osteoporoz Epigenetiği. Türk Osteoporoz Dergisi. 2023; 29(1): 1 - 9. 10.4274/tod.galenos.2022.80148
Vancouver	tural s,TEKCAN E,Tural E Osteoporoz Epigenetiği. Türk Osteoporoz Dergisi. 2023; 29(1): 1 - 9. 10.4274/tod.galenos.2022.80148
IEEE	tural s,TEKCAN E,Tural E "Osteoporoz Epigenetiği." Türk Osteoporoz Dergisi, 29, ss.1 - 9, 2023. 10.4274/tod.galenos.2022.80148
ISNAD	tural, sengul vd. "Osteoporoz Epigenetiği". Türk Osteoporoz Dergisi 29/1 (2023), 1-9. https://doi.org/10.4274/tod.galenos.2022.80148