Comparison of liver resection and living donor liver  transplantation in patients with hepatocellular carcinoma  within Milan criteria and well-preserved liver function

Yilmaz, Sezai; ince, volkan; DALDA, YASİN; Akbulut, Sami; KARAKAS, SERDAR; AKATLI, Ayse Nur; Kahraman, Aysegul Sagir; Kutlu, Ramazan; Carr, Brian

doi:10.14744/hf.2023.2023.0005

Comparison of liver resection and living donor liver transplantation in patients with hepatocellular carcinoma within Milan criteria and well-preserved liver function

Serdar KARAKAS, (İnönü Üniversitesi, Tıp Fakültesi, Cerrahi ve Karaciğer Nakli Anabilim Dalı, Malatya, Türkiye)

Sezai YILMAZ, (İnönü Üniversitesi, Tıp Fakültesi, Cerrahi ve Karaciğer Nakli Anabilim Dalı, Malatya, Türkiye)

Volkan İNCE, (İnönü Üniversitesi, Tıp Fakültesi, Cerrahi ve Karaciğer Nakli Anabilim Dalı, Malatya, Türkiye)

AHMET SAMİ AKBULUT, (İnönü Üniversitesi, Tıp Fakültesi, Cerrahi ve Karaciğer Nakli Anabilim Dalı, Malatya, Türkiye)

Yasin DALDA, (İnönü Üniversitesi, Tıp Fakültesi, Cerrahi ve Karaciğer Nakli Anabilim Dalı, Malatya, Türkiye)

Ayşe Nur AKATLI, (İnönü Üniversitesi, Tıp Fakültesi, Yüksekokulu Patoloji Anabilim Dalı, Malatya, Türkiye)

Aysegul Sagir KAHRAMAN, (İnönü Üniversitesi, Tıp Fakültesi, Radyoloji Anabilim Dalı, Malatya, Türkiye)

Ramazan KUTLU, (İnönü Üniversitesi, Tıp Fakültesi, Girişimsel Radyoloji Anabilim Dalı, Malatya, Türkiye)

Brian I. CARR (İnönü Üniversitesi, Tıp Fakültesi, Cerrahi ve Karaciğer Nakli Anabilim Dalı, Malatya, Türkiye)

Hepatology forum

2 0

Yıl: 2023 Cilt: 4 Sayı: 2 Sayfa Aralığı: 47 - 52 Metin Dili: İngilizce DOI: 10.14744/hf.2023.2023.0005 İndeks Tarihi: 03-06-2023

Comparison of liver resection and living donor liver transplantation in patients with hepatocellular carcinoma within Milan criteria and well-preserved liver function

Öz:

Background and Aim: Liver resection (LR) and liver transplantation (LT) are curative treatments for hepatocellular carcinoma (HCC). The main pur pose of this study was to compare the survival of LR and LDLT in patients with HCC within the Milan criteria. Materials and Methods: The results of the LR (n=67) and LDLT (n=391) groups were compared for overall survival (OS) and disease-free survival (DFS). Twenty-six of the HCCs in the LRs met the Milan and Child A cri teria. Also, 200 of the HCC patients in the LDLTs met the Milan criteria, of which 70 also met the Child A criteria. Results: Early mortality was higher in the LDLT group (13.9% vs 1.47%; p=0.003). The 5-year OS was higher in the LDLTs than the LRs, but not statistically significant (84.6% vs 74.2%; p=0.287). However, 5-year DFS was better in the LDLT group (96.8% vs 64.3%; p<0.001). When the LRs (n=26) and the LDLTs (n=70) that met both Milan and Child A criteria were compared, 5-year OS was similar (81.4% vs 74.2%; p=0.512), but DFS was better in the LDLTs (98.6% vs 64.3%; p<0.001). Conclusion: LR can be justified as the first-line treatment for HCC patients who meet Milan and Child A criteria in terms of early mortality and OS

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	KARAKAS S, Yilmaz S, ince v, Akbulut S, DALDA Y, AKATLI A, Kahraman A, Kutlu R, Carr B (2023). Comparison of liver resection and living donor liver transplantation in patients with hepatocellular carcinoma within Milan criteria and well-preserved liver function. , 47 - 52. 10.14744/hf.2023.2023.0005
Chicago	KARAKAS SERDAR,Yilmaz Sezai,ince volkan,Akbulut Sami,DALDA YASİN,AKATLI Ayse Nur,Kahraman Aysegul Sagir,Kutlu Ramazan,Carr Brian Comparison of liver resection and living donor liver transplantation in patients with hepatocellular carcinoma within Milan criteria and well-preserved liver function. (2023): 47 - 52. 10.14744/hf.2023.2023.0005
MLA	KARAKAS SERDAR,Yilmaz Sezai,ince volkan,Akbulut Sami,DALDA YASİN,AKATLI Ayse Nur,Kahraman Aysegul Sagir,Kutlu Ramazan,Carr Brian Comparison of liver resection and living donor liver transplantation in patients with hepatocellular carcinoma within Milan criteria and well-preserved liver function. , 2023, ss.47 - 52. 10.14744/hf.2023.2023.0005
AMA	KARAKAS S,Yilmaz S,ince v,Akbulut S,DALDA Y,AKATLI A,Kahraman A,Kutlu R,Carr B Comparison of liver resection and living donor liver transplantation in patients with hepatocellular carcinoma within Milan criteria and well-preserved liver function. . 2023; 47 - 52. 10.14744/hf.2023.2023.0005
Vancouver	KARAKAS S,Yilmaz S,ince v,Akbulut S,DALDA Y,AKATLI A,Kahraman A,Kutlu R,Carr B Comparison of liver resection and living donor liver transplantation in patients with hepatocellular carcinoma within Milan criteria and well-preserved liver function. . 2023; 47 - 52. 10.14744/hf.2023.2023.0005
IEEE	KARAKAS S,Yilmaz S,ince v,Akbulut S,DALDA Y,AKATLI A,Kahraman A,Kutlu R,Carr B "Comparison of liver resection and living donor liver transplantation in patients with hepatocellular carcinoma within Milan criteria and well-preserved liver function." , ss.47 - 52, 2023. 10.14744/hf.2023.2023.0005
ISNAD	KARAKAS, SERDAR vd. "Comparison of liver resection and living donor liver transplantation in patients with hepatocellular carcinoma within Milan criteria and well-preserved liver function". (2023), 47-52. https://doi.org/10.14744/hf.2023.2023.0005

APA	KARAKAS S, Yilmaz S, ince v, Akbulut S, DALDA Y, AKATLI A, Kahraman A, Kutlu R, Carr B (2023). Comparison of liver resection and living donor liver transplantation in patients with hepatocellular carcinoma within Milan criteria and well-preserved liver function. Hepatology forum, 4(2), 47 - 52. 10.14744/hf.2023.2023.0005
Chicago	KARAKAS SERDAR,Yilmaz Sezai,ince volkan,Akbulut Sami,DALDA YASİN,AKATLI Ayse Nur,Kahraman Aysegul Sagir,Kutlu Ramazan,Carr Brian Comparison of liver resection and living donor liver transplantation in patients with hepatocellular carcinoma within Milan criteria and well-preserved liver function. Hepatology forum 4, no.2 (2023): 47 - 52. 10.14744/hf.2023.2023.0005
MLA	KARAKAS SERDAR,Yilmaz Sezai,ince volkan,Akbulut Sami,DALDA YASİN,AKATLI Ayse Nur,Kahraman Aysegul Sagir,Kutlu Ramazan,Carr Brian Comparison of liver resection and living donor liver transplantation in patients with hepatocellular carcinoma within Milan criteria and well-preserved liver function. Hepatology forum, vol.4, no.2, 2023, ss.47 - 52. 10.14744/hf.2023.2023.0005
AMA	KARAKAS S,Yilmaz S,ince v,Akbulut S,DALDA Y,AKATLI A,Kahraman A,Kutlu R,Carr B Comparison of liver resection and living donor liver transplantation in patients with hepatocellular carcinoma within Milan criteria and well-preserved liver function. Hepatology forum. 2023; 4(2): 47 - 52. 10.14744/hf.2023.2023.0005
Vancouver	KARAKAS S,Yilmaz S,ince v,Akbulut S,DALDA Y,AKATLI A,Kahraman A,Kutlu R,Carr B Comparison of liver resection and living donor liver transplantation in patients with hepatocellular carcinoma within Milan criteria and well-preserved liver function. Hepatology forum. 2023; 4(2): 47 - 52. 10.14744/hf.2023.2023.0005
IEEE	KARAKAS S,Yilmaz S,ince v,Akbulut S,DALDA Y,AKATLI A,Kahraman A,Kutlu R,Carr B "Comparison of liver resection and living donor liver transplantation in patients with hepatocellular carcinoma within Milan criteria and well-preserved liver function." Hepatology forum, 4, ss.47 - 52, 2023. 10.14744/hf.2023.2023.0005
ISNAD	KARAKAS, SERDAR vd. "Comparison of liver resection and living donor liver transplantation in patients with hepatocellular carcinoma within Milan criteria and well-preserved liver function". Hepatology forum 4/2 (2023), 47-52. https://doi.org/10.14744/hf.2023.2023.0005