Yıl: 2023 Cilt: 39 Sayı: 1 Sayfa Aralığı: 70 - 75 Metin Dili: İngilizce DOI: 10.47717/turkjsurg.2023.5886 İndeks Tarihi: 03-06-2023

The effect of different therapeutic treatments on the frequency of postoperative hypocalcemia in patients with thyroidectomy

Öz:
Objective: Thyroid gland surgery and its surgical complications are situations that a surgeon frequently encounters in his daily practice. In our study, it was aimed to examine the effect of different treatment methods given to patients who underwent thyroidectomy on hypocalcemia. Material and Methods: Three hundred and seventy-one patients who underwent thyroidectomy at Ondokuz Mayıs University Medical Faculty General Surgery clinic between December 2016 and January 2021 were retrospectively included in the study. Parameters such as surgery indications, fine needle aspiration biopsy results, preoperative serum calcium values, type of surgery, serum calcium values at postoperative 1st day and 1st month, postoperative hospital stay, drugs prescribed at discharge, histopathological diagnosis of the patient, and whether there was incidental parathyroidectomy or not were included. Results: Mean age of 371 patients who underwent thyroidectomy was 49 (19-82) years. Total thyroidectomy was the most common type of thyroidectomy with 61% (n= 225) of the patients. There was a significant decrease in pre-op and post-op calcium values in all three types of surgery performed on the patients, and there was no significant difference between the different types of surgery. Post-operative day one and month one serum calcium values were significantly increased in all groups (p= .000). The increase in post-op serum calcium level was most common in the group using calcium carbonate + cholecalciferol + calcitriol. Conclusion: The use of post-op calcitriol in patients undergoing thyroidectomy seems to be quite effective in preventing the development of hypocalcemia.
Anahtar Kelime:

Tiroidektomi olan hastalarda farklı terapötik tedavilerin postoperatif hipokalsemi sıklığına etkisi

Öz:
Giriş ve Amaç: Tiroid bezi cerrahisi ve cerrahi komplikasyonları cerrahın günlük pratiğinde sıklıkla karşılaştığı durumlardır. Çalışmamızda tiroidektomi yapılan hastalara verilen farklı tedavi yöntemlerinin hipokalsemiye etkisinin incelenmesi amaçlanmıştır. Gereç ve Yöntem: Çalışmaya Aralık 2016- Ocak 2021 yılları arasında Ondokuz Mayıs Üniversitesi Tıp Fakültesi Genel Cerrahi kliniğinde tiroidektomi uygulanan 371 hasta retrospektif olarak dahil edildi. Hastaların ameliyat endikasyonları, ince iğne aspirasyon biyopsisi sonuçları, preoperatif serum kalsiyum değerleri, ameliyat tipi, postoperatif birinci gün ve birinci aydaki serum kalsiyum değerleri, postoperatif yatış süresi, taburculukta reçete edilen ilaçlar, hastanın histopatolojik tanısı, insidental paratioridektomi olup olmadığı gibi parametreler çalışmaya dahil edildi. Bulgular: Tiroidektomi yapılan 371 hastanın ortalama yaşı 49 (19-82) yıl idi. Hastalara %61 (n= 225) ile en çok total tiroidektomi uygulanmıştı. Hastalara uygulanan üç ameliyat tipinde de pre-op ve post-op kalsiyum değerlerinde anlamlı düşüş mevcut olup farklı ameliyat tipleri arasında belirgin fark görülmemiştir. Tüm gruplarda post-op birinci gün ve birinci ay serum kalsiyum değerleri anlamlı derecede yükselmiştir (p= ,000). Post-op serum kalsiyum düzeyi artışı en çok kalsiyum karbonat + kolekalsiferol + kalsitriol kullanan grupta olmuştur. Sonuç: Tiroidektomi uygulanan hastalarda post-op kalsitriol kullanımı hipokalsemi gelişimini önlemede oldukça etkili görünmektedir.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
0
0
0
  • 1. Lorenz K, Raffaeli M, Barczyński M, Lorente-Poch L, Sancho J. Volume, outcomes, and quality standards in thyroid surgery: An evidencebased analysis. ESES positional statement Langenbecks Arch Surg 2020; 405(4): 401-25. https://doi.org/10.1007/s00423-020-01907-x
  • 2. Medas F, Tuveri M, Canu GL, Erdas E, Calò PG. Complications after reoperative thyroid surgery: Retrospective evaluation of 152 consecutive cases. Updates Surg 2019; 71(4): 705-10. https://doi.org/10.1007/ s13304-019-00647-y
  • 3. Shuja A. History of thyroid surgery. Professional Med J 2008; 15(02): 295-7. https://doi.org/10.29309/TPMJ/2008.15.02.2813
  • 4. Sarkar S, Banerjee S, Sarkar R, Sikder B. A review on the history of ‘thyroid surgery’. Indian J Surg 2016; 78(1): 32-6. https://doi.org/10.1007/ s12262-015-1317-5
  • 5. Hannan SA. The magnificent seven: A history of modern thyroid surgery. Int J Surg 2006; 4(3): 187-91. https://doi.org/10.1016/j. ijsu.2006.03.002
  • 6. Duntas LH. Seven decades of levothyroxine: A comprehensive profile. Springer; 2019; 27-9. https://doi.org/10.1007/s12325-019-01081-7
  • 7. Collins R, Lafford G, Ferris R, Turner J, Tassone P. Improving the management of post-operative hypocalcaemia in thyroid surgery. Cureus 2021; 13(5). https://doi.org/10.7759/cureus.15137
  • 8. Sözen S, Emir S, Alıcı A, Aysu F, Yıldız F, Aziret, et al. Complications after thyroidectomy and the affecting factors related with the surgeon. Turk Surg J 2010; 26: 13-7. https://doi.org/10.5097/1300-0705. UCD.315-10.02
  • 9. Christou N, Mathonnet M. Complications after total thyroidectomy. J Visc Surg 2013; 150(4): 249-56. https://doi.org/10.1016/j.jviscsurg.2013.04.003
  • 10. Orloff LA, Wiseman SM, Bernet VJ, Fahey III TJ, Shaha AR, Shindo ML, et al. American Thyroid Association statement on postoperative hypoparathyroidism: Diagnosis, prevention, and management in adults. Thyroid 2018; 28(7): 830-41. https://doi.org/10.1089/ thy.2017.0309
  • 11. Harness JK, Fung L, Thompson NW, Burney RE, McLeod MK. Total thyroidectomy: Complications and technique. World J Surg 1986; 10(5): 781-5. https://doi.org/10.1007/BF01655238
  • 12. Thomusch O, Machens A, Sekulla C, Ukkat J, Lippert H, Gastinger I, et al. Multivariate analysis of risk factors for postoperative complications in benign goiter surgery: Prospective multicenter study in Germany. World J Surg 2000; 24(11): 1335-41. https://doi.org/10.1007/ s002680010221
  • 13. Kalyoncu D, Gönüllü D, Gedik ML, Er M, Kuroğlu E, İğdem AA, et al. Analysis of the factors that have an effect on hypocalcemia following thyroidectomy. Ulus Cerrahi Derg 2013; 29(4): 171-6. https://doi. org/10.5152/UCD.2013.2438
  • 14. Cannizzaro MA, Borzì L, Lo Bianco S, Okatyeva V, Cavallaro A, Buffone A, et al. Comparison between focus harmonic scalpel and other hemostatic techniques in open thyroidectomy: A systematic review and meta-analysis. Head Neck 2016; 38(10): 1571-8. https://doi. org/10.1002/hed.24449
  • 15. Makay Ö, Özdemir M, Şenyürek YG, Tunca F, Düren M, Uludağ M, et al. Surgical approaches for papillary microcarcinomas: Turkey’s perspective. Turk J Surg 2018; 34(2): 89-93. https://doi.org/10.5152/turkjsurg.2018.3596
  • 16. Bai B, Chen Z, Chen W. Risk factors and outcomes of incidental parathyroidectomy in thyroidectomy: A systematic review and metaanalysis. PLoS One 2018; 13(11): e0207088. https://doi.org/10.1371/ journal.pone.0207088
  • 17. Mazotas IG, Wang TS. The role and timing of parathyroid hormone determination after total thyroidectomy. Gland Surg 2017; 6(Suppl 1): 38-48. https://doi.org/10.21037/gs.2017.09.06
  • 18. Reddy AC, Chand G, Sabaretnam M, Mishra A, Agarwal G, Agarwal A, et al. Prospective evaluation of intra-operative quick parathyroid hormone assay as an early predictor of post thyroidectomy hypocalcaemia. Int J Surg 2016; 34: 103-8. https://doi.org/10.1016/j. ijsu.2016.08.010
  • 19. Lecerf P, Orry D, Perrodeau E, Lhommet C, Charretier C, Mor C, et al. Parathyroid hormone decline 4 hours after total thyroidectomy accurately predicts hypocalcemia. Surgery 2012; 152(5): 863-8. https://doi. org/10.1016/j.surg.2012.03.011
  • 20. Alhefdhi A, Mazeh H, Chen H. Role of postoperative vitamin D and/or calcium routine supplementation in preventing hypocalcemia after thyroidectomy: A systematic review and meta-analysis. Oncologist 2013; 18(5): 533-42. https://doi.org/10.1634/theoncologist.2012-0283
  • 21. Tolone S, Roberto R, del Genio G, Brusciano L, Parmeggiani D, Amoroso V, et al. The impact of age and oral calcium and vitamin D supplements on postoperative hypocalcemia after total thyroidectomy. A prospective study. BMC Surg 2013; 13(2): 1-6. https://doi. org/10.1186/1471-2482-13-S2-S11
APA PİYADE H, Basoglu M, GÜRSOY E (2023). The effect of different therapeutic treatments on the frequency of postoperative hypocalcemia in patients with thyroidectomy. , 70 - 75. 10.47717/turkjsurg.2023.5886
Chicago PİYADE HAMDİ BURAK,Basoglu Mahmut,GÜRSOY ERSAN The effect of different therapeutic treatments on the frequency of postoperative hypocalcemia in patients with thyroidectomy. (2023): 70 - 75. 10.47717/turkjsurg.2023.5886
MLA PİYADE HAMDİ BURAK,Basoglu Mahmut,GÜRSOY ERSAN The effect of different therapeutic treatments on the frequency of postoperative hypocalcemia in patients with thyroidectomy. , 2023, ss.70 - 75. 10.47717/turkjsurg.2023.5886
AMA PİYADE H,Basoglu M,GÜRSOY E The effect of different therapeutic treatments on the frequency of postoperative hypocalcemia in patients with thyroidectomy. . 2023; 70 - 75. 10.47717/turkjsurg.2023.5886
Vancouver PİYADE H,Basoglu M,GÜRSOY E The effect of different therapeutic treatments on the frequency of postoperative hypocalcemia in patients with thyroidectomy. . 2023; 70 - 75. 10.47717/turkjsurg.2023.5886
IEEE PİYADE H,Basoglu M,GÜRSOY E "The effect of different therapeutic treatments on the frequency of postoperative hypocalcemia in patients with thyroidectomy." , ss.70 - 75, 2023. 10.47717/turkjsurg.2023.5886
ISNAD PİYADE, HAMDİ BURAK vd. "The effect of different therapeutic treatments on the frequency of postoperative hypocalcemia in patients with thyroidectomy". (2023), 70-75. https://doi.org/10.47717/turkjsurg.2023.5886
APA PİYADE H, Basoglu M, GÜRSOY E (2023). The effect of different therapeutic treatments on the frequency of postoperative hypocalcemia in patients with thyroidectomy. Turkish Journal of Surgery, 39(1), 70 - 75. 10.47717/turkjsurg.2023.5886
Chicago PİYADE HAMDİ BURAK,Basoglu Mahmut,GÜRSOY ERSAN The effect of different therapeutic treatments on the frequency of postoperative hypocalcemia in patients with thyroidectomy. Turkish Journal of Surgery 39, no.1 (2023): 70 - 75. 10.47717/turkjsurg.2023.5886
MLA PİYADE HAMDİ BURAK,Basoglu Mahmut,GÜRSOY ERSAN The effect of different therapeutic treatments on the frequency of postoperative hypocalcemia in patients with thyroidectomy. Turkish Journal of Surgery, vol.39, no.1, 2023, ss.70 - 75. 10.47717/turkjsurg.2023.5886
AMA PİYADE H,Basoglu M,GÜRSOY E The effect of different therapeutic treatments on the frequency of postoperative hypocalcemia in patients with thyroidectomy. Turkish Journal of Surgery. 2023; 39(1): 70 - 75. 10.47717/turkjsurg.2023.5886
Vancouver PİYADE H,Basoglu M,GÜRSOY E The effect of different therapeutic treatments on the frequency of postoperative hypocalcemia in patients with thyroidectomy. Turkish Journal of Surgery. 2023; 39(1): 70 - 75. 10.47717/turkjsurg.2023.5886
IEEE PİYADE H,Basoglu M,GÜRSOY E "The effect of different therapeutic treatments on the frequency of postoperative hypocalcemia in patients with thyroidectomy." Turkish Journal of Surgery, 39, ss.70 - 75, 2023. 10.47717/turkjsurg.2023.5886
ISNAD PİYADE, HAMDİ BURAK vd. "The effect of different therapeutic treatments on the frequency of postoperative hypocalcemia in patients with thyroidectomy". Turkish Journal of Surgery 39/1 (2023), 70-75. https://doi.org/10.47717/turkjsurg.2023.5886