Hücrelerde Sıvı-Sıvı Faz Ayırımı ile Oluşan Membransız Cisimcikler: Literatür Derlemesi

BORA, Gamze; GUMUS, Dudu

doi:10.5505/ktd.2022.56255

Hücrelerde Sıvı-Sıvı Faz Ayırımı ile Oluşan Membransız Cisimcikler: Literatür Derlemesi

Dudu GUMUS, (Hacettepe Üniversitesi Tıp Fakültesi, Tıbbi Biyoloji Anabilim Dalı, Ankara, Türkiye)

Gamze BORA (Hacettepe Üniversitesi Tıp Fakültesi, Tıbbi Biyoloji Anabilim Dalı, Ankara, Türkiye)

Kocaeli Tıp Dergisi

2 0

Yıl: 2023 Cilt: 12 Sayı: 1 Sayfa Aralığı: 75 - 88 Metin Dili: Türkçe DOI: 10.5505/ktd.2022.56255 İndeks Tarihi: 03-06-2023

Hücrelerde Sıvı-Sıvı Faz Ayırımı ile Oluşan Membransız Cisimcikler: Literatür Derlemesi

Öz:

Ökaryotik hücrelerde biyokimyasal süreçler organel adı verilen hücresel kompartmanlarda gerçekleşmektedir. Hücre içinde membranla çevrili organellerin yanı sıra membranla çevrelenmeyen yapılar da bulunmakta ve bu yapılar membransız cisimcikler olarak adlandırılmaktadır. Sıvı-sıvı faz ayırımı mekanizmasıyla oluşan bu cisimcikler, çekirdekte veya sitoplazmada oluşarak biyokimyasal süreçlerin hızlı ve verimli olarak gerçekleşmesini sağlamaktadır. Membransız cisimciklerde farklı hastalık gruplarında değişikliklerin saptanması nedeniyle, cisimciklerin yapı ve oluşumlarının anlaşılabilmesine yönelik araştırmalar son yıllarda hız kazanmıştır. Bu derlemede fizyolojik ve patolojik süreçlerde oluşan membransız cisimciklerin oluşum mekanizmaları, yapıları ve görevleri özetlenmiştir.

Anahtar Kelime:

Membraneless Bodies of Cells Formed by Liquid-Liquid Phase Separation: Literature Review

Öz:

Biochemical processes occur in cellular compartments, called organelles, in eukaryotic cells. In addition to membrane-enclosed organelles, non-membrane bound structures, namely membraneless bodies, are also found in cells. These bodies are formed in nucleus or cytoplasm by liquid-liquid phase separation mechanism and ensure that biochemical processes take place rapidly and efficiently. Since, alterations have been detected in membraneless bodies in different disease groups, investigations about the structure and formation of bodies have been accelerated in recent years. In this review, the mechanism of formation and structures of membraneless bodies were summarized in physiological and pathological states.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Derleme Erişim Türü: Erişime Açık

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APA	GUMUS D, BORA G (2023). Hücrelerde Sıvı-Sıvı Faz Ayırımı ile Oluşan Membransız Cisimcikler: Literatür Derlemesi. , 75 - 88. 10.5505/ktd.2022.56255
Chicago	GUMUS Dudu,BORA Gamze Hücrelerde Sıvı-Sıvı Faz Ayırımı ile Oluşan Membransız Cisimcikler: Literatür Derlemesi. (2023): 75 - 88. 10.5505/ktd.2022.56255
MLA	GUMUS Dudu,BORA Gamze Hücrelerde Sıvı-Sıvı Faz Ayırımı ile Oluşan Membransız Cisimcikler: Literatür Derlemesi. , 2023, ss.75 - 88. 10.5505/ktd.2022.56255
AMA	GUMUS D,BORA G Hücrelerde Sıvı-Sıvı Faz Ayırımı ile Oluşan Membransız Cisimcikler: Literatür Derlemesi. . 2023; 75 - 88. 10.5505/ktd.2022.56255
Vancouver	GUMUS D,BORA G Hücrelerde Sıvı-Sıvı Faz Ayırımı ile Oluşan Membransız Cisimcikler: Literatür Derlemesi. . 2023; 75 - 88. 10.5505/ktd.2022.56255
IEEE	GUMUS D,BORA G "Hücrelerde Sıvı-Sıvı Faz Ayırımı ile Oluşan Membransız Cisimcikler: Literatür Derlemesi." , ss.75 - 88, 2023. 10.5505/ktd.2022.56255
ISNAD	GUMUS, Dudu - BORA, Gamze. "Hücrelerde Sıvı-Sıvı Faz Ayırımı ile Oluşan Membransız Cisimcikler: Literatür Derlemesi". (2023), 75-88. https://doi.org/10.5505/ktd.2022.56255

APA	GUMUS D, BORA G (2023). Hücrelerde Sıvı-Sıvı Faz Ayırımı ile Oluşan Membransız Cisimcikler: Literatür Derlemesi. Kocaeli Tıp Dergisi, 12(1), 75 - 88. 10.5505/ktd.2022.56255
Chicago	GUMUS Dudu,BORA Gamze Hücrelerde Sıvı-Sıvı Faz Ayırımı ile Oluşan Membransız Cisimcikler: Literatür Derlemesi. Kocaeli Tıp Dergisi 12, no.1 (2023): 75 - 88. 10.5505/ktd.2022.56255
MLA	GUMUS Dudu,BORA Gamze Hücrelerde Sıvı-Sıvı Faz Ayırımı ile Oluşan Membransız Cisimcikler: Literatür Derlemesi. Kocaeli Tıp Dergisi, vol.12, no.1, 2023, ss.75 - 88. 10.5505/ktd.2022.56255
AMA	GUMUS D,BORA G Hücrelerde Sıvı-Sıvı Faz Ayırımı ile Oluşan Membransız Cisimcikler: Literatür Derlemesi. Kocaeli Tıp Dergisi. 2023; 12(1): 75 - 88. 10.5505/ktd.2022.56255
Vancouver	GUMUS D,BORA G Hücrelerde Sıvı-Sıvı Faz Ayırımı ile Oluşan Membransız Cisimcikler: Literatür Derlemesi. Kocaeli Tıp Dergisi. 2023; 12(1): 75 - 88. 10.5505/ktd.2022.56255
IEEE	GUMUS D,BORA G "Hücrelerde Sıvı-Sıvı Faz Ayırımı ile Oluşan Membransız Cisimcikler: Literatür Derlemesi." Kocaeli Tıp Dergisi, 12, ss.75 - 88, 2023. 10.5505/ktd.2022.56255
ISNAD	GUMUS, Dudu - BORA, Gamze. "Hücrelerde Sıvı-Sıvı Faz Ayırımı ile Oluşan Membransız Cisimcikler: Literatür Derlemesi". Kocaeli Tıp Dergisi 12/1 (2023), 75-88. https://doi.org/10.5505/ktd.2022.56255