TY  - JOUR
TI  - Electroconvulsive Therapy and Extracellular Matrix Glycoproteins in Patients with Depressive Episodes
AB  - Background: The brain extracellular matrix (ECM) is composed of glycoproteins deriving from the cell membrane and joining into nets called perineuronal nets (PNNs). The ECM glycoproteins limit neuroplasticity, cell proliferation, and differentiation. Electroconvulsive therapy (ECT) is provided by  electrical currents that may alter several cascades and biophysical effects. ECM conformation might be  influenced by the effects of ECT. Methods: Patients with depressive disorders (n = 23) and healthy control subjects (n = 21) were enrolled. Serum levels of the ECM glycoproteins versican, brevican, neurocan, phosphocan and tenascin C were measured with enzyme-linked immunosorbent assay. Serum samples were collected from the patients in the patient group at 3 time points: before ECT, 30 min after the first session, and 30 min  after the seventh session. Results: There was a significant difference in tenascin C levels (P = .001) between the groups. No other significant  difference  was  observed.  Serum  levels  of  the  measured  ECM  glycoproteins  and  prolidase  activity did not differ in the depression group after the administration of ECT. Conclusions: Our results did not support the claim suggesting a possible mechanism for modulation of ECM glycoproteins by ECT. Serum levels may not necessarily reflect conformational changes in the ECM.  Further studies are needed to investigate the effects of ECT on ECM glycoproteins. Modulation of the  ECM may provide a new window suggesting improvement in treatments.
AU  - EREL, Ozcan
AU  - balaban, özlem devrim
AU  - Karamustafalıoğlu, Nesrin
AU  - alpuğan, barış
AU  - İlnem, Mehmet Cem
AU  - Ipekcioglu, Derya
AU  - Yalçın, Suat
AU  - canbek, ozge
AU  - Atagün, Murat İlhan
AU  - ŞENAT, Almila
DO  - 10.5152/pcp.2021.20161
PY  - 2021
JO  - Psychiatry and clinical psychopharmacology (Online)
VL  - 31
IS  - 2
SN  - 2475-0581
SP  - 157
EP  - 164
DB  - TRDizin
UR  - http://search/yayin/detay/1179139
ER  -