TY  - JOUR
TI  - ASSESSMENT OF DISEASE ACITIVITY IN MULTIPLE SCLEROSIS VIA FETUIN-A LEVELS
AB  - Introduction: Fetuin-A is a glycoprotein found to be elevated in the cerebrospinal fluid (CSF) of patients with multiple sclerosis (MS). Examination of fetuin-A in MS may contribute to the our understanding of MS pathophysiology. We aimed to examine CSF and serum levels of fetuin-A in MS patients, and to assess relationships with disease activity. Materials and Methods: Twenty-two patients, classified as definite MS (n = 15) and clinically isolated syndrome (CIS, n = 7), and 27 age- and sex-matched cases with pseudotumor cerebri were included in the study. The ELISA method was used to determine fetuin-A levels in the CSF samples of the patient and control groups. Results: The patient and control groups were similar in terms of sex distribution, but mean age was significantly lower in patients (31.5 vs. 39.3 years, p>0.05).While patients and controls had similar fetuin-A levels at baseline and on the 6th month, CSF fetuin-A levels were significantly higher in patients with MS (p=0.01) compared to those with CIS.Patients with active and inactive disease had similar fetuin-A levelsin all comparisons, but patients with active disease appeared to have some what higher fetuin-A compared to those with inactive disease. Conclusion: To conclude, our findings showed that patients with MS and controls had similar fetuin-A levels (serum and CSF). However, at baseline, patients with MS had significantly higher fetuin-A concentrations compared to those with CIS. Fetuin-A levels were not si gnificantly associated with disease activity, but patients with active disease seemed to have relatively higher levels than those with inactive disease.
AU  - Bilen, Sule
AU  - Oztekin, Nese
AU  - KILINCKAYA, Muhammed Fevzi
AU  - Mühürdaroğlu, Mehmet
AU  - eruyar, esra
PY  - 2023
JO  - İzmir Eğitim ve Araştırma Hastanesi Tıp Dergisi
VL  - 27
IS  - 2
SN  - 1305-5151
SP  - 158
EP  - 164
DB  - TRDizin
UR  - http://search/yayin/detay/1179335
ER  -