The in-vitro Wound Healing Potential of Essential Oil Extracted from Mentha longifolia L.

Selma SEZEN, (Ağrı İbrahim Çeçen Üniversitesi, Tıp Fakültesi, Tıbbi Farmakoloji Anabilim Dalı, Ağrı, Türkiye)
Muhammed Sait ERTUĞRUL, (Ondokuz Mayıs Üniversitesi, Kenevir Araştırma Enstitüsü, Samsun, Türkiye)
Cemil BAYRAM, (Atatürk Üniversitesi, Veteriner Fakültesi Farmakoloji ve Toksikoloji Anabilim Dalı, Erzurum, Türkiye)
Mustafa ÖZKARACA, (Sivas Cumhuriyet Üniversitesi, Patoloji Anabilim Dalı, Veteriner Fakültesi, Sivas, Türkiye)
Taha Yasin KOÇ, (Atatürk Üniversitesi, Fen Bilimleri Enstitüsü, Erzurum, Türkiye)
Abdussamed Yasin DEMİR, (Erzincan Binali Yıldırım Üniversitesi, Tıbbi Genetik Anabilim Dalı, Erzincan, Türkiye)
Medine GÜLLÜCE, (Atatürk Üniversitesi, Fen Fakültesi, Biyoloji Bölümü, Erzurum, Türkiye)
Ahmet HACIMÜFTÜOĞLU (Atatürk Üniversitesi, Tıp Fakültesi, Tıbbi Farmakoloji Anabilim Dalı, Erzurum, Türkiye)
Journal of research in pharmacy (online)
9 0
Yıl: 2023 Cilt: 27 Sayı: 3 Sayfa Aralığı: 1220 - 1233 Metin Dili: İngilizce DOI: 10.29228/jrp.411 İndeks Tarihi: 06-06-2023

The in-vitro Wound Healing Potential of Essential Oil Extracted from Mentha longifolia L.

Öz:
Products from Mentha species are widely used in medical applications, including wound healing, due to the bioactive compounds they may contain. However, data on the effect of Mentha longifolia L. on wound healing are limited. This study investigated the antimicrobial and wound healing-promoting effects of Mentha longifolia L. essential oil using in vitro methods. The chemical compositions of the essential oil were identified using gas chromatography/mass spectrometry, while the agar well diffusion and disk diffusion methods were used to determine antimicrobial activity against pathogenic strains. A scratch wound healing assay was performed following determination of the cytotoxic dose in human fibroblast cell lines. The media were used for biochemical analysis 48 h after the in vitro wound model. Immunohistochemical staining was applied to determine the contribution of the essential oil to wound healing. The essential oil exhibited varying levels of antimicrobial activity against the tested pathogens and increased cell viability. All doses in the scratch wound healing assay promoted wound closure in a shorter time than in the control group. TAC levels were higher in the treated groups than in the control group, while TOS, IL-6, and TNF-α levels were lower. Levels of expression of FGF 2, IGF, and TGF-β were higher in the treated groups than in the control group at increasing doses. The essential oil of Mentha longifolia L. exhibited antimicrobial effects and improved wound healing at doses of 5 µg/mL and 10 µg/mL.
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  • [1] Wilkinson HN, Hardman MJ. Wound healing: cellular mechanisms and pathological outcomes. Open Biol. 2020; 10(9): 200223. https://doi.org/10.1098/rsob.200223
  • [2] Sen CK. Human wounds and its burden: An updated compendium of estimates. Adv Wound Care. 2029; 8(2): 39-48. https://doi.org/10.1089/wound.2019.0946
  • [3] Broughton G, Janis JE, Attinger CE. Wound healing: an overview. Plast Reconstr Surg. 2006: 117(7 Suppl): 1e-S-32e S. https://doi.org/10.1097/01.prs.0000222562.60260.f9
  • [4] Guvenalp Z, Ozbek H, Karadayi M, Gulluce M, Kuruuzum-Uz A, Salih B, Demirezer O. Two antigenotoxic chalcone glycosides from Mentha longifolia subsp. longifolia. Pharm Biol. 2015; 53(6): 888-896. https://doi.org/10.3109/13880209.2014.948633
  • [5] El Hassani FZ. Characterization, activities, and ethnobotanical uses of Mentha species in Morocco. Heliyon. 2020; 6(11): e05480. https://doi.org/10.1016/j.heliyon.2020.e05480
  • [6] Zouari-Bouassida K, Trigui M, Makni S, Jlaiel L, Tounsi S. Seasonal variation in essential oils composition and the biological and pharmaceutical protective effects of Mentha longifolia leaves grown in Tunisia. Biomed Res Int. 2018; 7856517. https://doi.org/10.1155/2018/7856517
  • [7] Liaqat I, Riaz N, Saleem QUA, Tahir HM, Arshad M, Arshad N. Toxicological evaluation of essential oils from some plants of Rutaceae family. Evid Based Complement Alternat Med. 2018; 4394687. https://doi.org/10.1155/2018/4394687
  • [8] Alaylar B. Isolation and characterization of culturable endophytic plant growth promoting Bacillus species from Mentha longifolia L. Turk J Agric For 2022; 4: 73-82. https://doi.org/10.3906/tar-2109-24
  • [9] Mikaili P, Mojaverrostami S, Moloudizargari M, Aghajanshakeri S. Pharmacological and therapeutic effects of Mentha longifolia L. and its main constituent, menthol. Anc Sci Life. 2013; 33(2): 131-138. https://doi.org/10.4103%2F0257- 7941.139059
  • [10] Sim LY, Abd Rani NZ, Husain K. Lamiaceae: An insight on their anti-allergic potential and its mechanisms of action. Front Pharmacol. 2019; 10: 677. https://doi.org/10.3389/fphar.2019.00677
  • [11] Vaghardoost R, Ghavami Y, Sobouti B. The Effect of Mentha pulegium on healing of burn wound injuries in rat. World J Plast Surg 2019; 8(1): 43-50. https://doi.org/10.29252/wjps.8.1.43
  • [12] Modarresi M, Farahpour MR, Baradaran B. Topical application of Mentha piperita essential oil accelerates wound healing in infected mice model. Inflammopharmacol. 2019; 27(3): 531-537. https://doi.org/10.1007/s10787-018-0510- 0
  • [13] Singh N, Singh HP, Batish DR, Kohli RK, Yadav SS. Chemical characterization, phytotoxic, and cytotoxic activities of essential oil of Mentha longifolia. Environ Sci Pollut Res Int. 2020; 27(12): 13512-13523. https://doi.org/10.1007/s11356-020-07823-3
  • [14] Gharib FA, Mansour KH, Ahmed EZ, Galal TM. Heavy metals concentration, and antioxidant activity of the essential oil of the wild mint (Mentha longifolia L.) in the Egyptian watercourses. Int J Phytoremediation. 2021; 23(6): 641-651. https://doi.org/10.1080/15226514.2020.1847035
  • [15] Mimica-Dukić N, Bozin B, Soković M, Mihajlović B, Matavulj M. Antimicrobial and antioxidant activities of three Mentha species essential oils. Planta Med. 2003; 69(5): 413-419. https://doi.org/10.1055/s- 2003-39704
  • [16] Hajlaoui H, Trabelsi N, Noumi E, Snoussi M, Fallah H, Ksouri R, Bakhrouf A. Biological activities of the essential oils and methanol extract of tow cultivated mint species (Mentha longifolia and Mentha pulegium) used in the Tunisian folkloric medicine. World J Microbiol Biotechnol. 2009; 25: 2227–2238. https://doi.org/10.1007/s11274-009-0130-3
  • [17] Hafedh H, Fethi BA, Mejdi S, Emira N, Amina B. Effect of Mentha longifolia L. ssp longifolia essential oil on the morphology of four pathogenic bacteria visualized by atomic force microscopy. Afr J Microbiol Res. 2010; 4: 1122– 1127
  • [18] Mahmoudi H, Shokoohizadeh L, Fahim NZ, Bardebari AM, Moradkhani S, Alikhani MY. Detection of adeABC efllux pump encoding genes and antimicrobial effect of Mentha longifolia and menthol on MICs of imipenem and ciprofloxacin in clinical isolates of Acinetobacter baumannii. BMC Complement Med Ther. 2020; 20(1): 92. https://doi.org/10.1186/s12906-020-02887-7
  • [19] Shahverdi AR, Rafii F, Tavassoli F, Bagheri M, Attar F, Ghahraman A. Piperitone from Mentha longifolia var. chorodictya Rech F. reduces the nitrofurantoin resistance of strains of enterobacteriaceae. Phytother Res. 2004; 18(11): 911-914. https://doi.org/10.1002/ptr.1566
  • [20] Iraji A, Yazdanpanah S, Alizadeh F, Mirzamohammadi S, Ghasemi Y, Pakshir K, Yang Y, Zomorodian K. Screening the antifungal activities of monoterpenes and their isomers against Candida species. J Appl Microbiol. 2020; 129(6): 1541-1551. https://doi.org/10.1111/jam.14740
  • [21] Sezen S, Güllüce M, Kesmez Can F, Alaylar B. Essential oils and antimicrobial effects. Int J Sci Eng Res. 2019; 10(9): 65-70.
  • [22] Aelenei P, Miron A, Trifan A, Bujor A, Gille E, Aprotosoaie AC. Essential oils and their components as modulators of antibiotic activity against gram-negative bacteria. Medicines (Basel). 2016; 3(3): 19. https://doi.org/10.3390/medicines3030019
  • [23] Haikal A, El-Neketi M, Awadin WF, Hassan MA, Gohar AA. Essential oils from wild Mentha longifolia subspecies typhoides and subspecies shimperi: Burn wound healing and antimicrobial candidates. J King Saud Univ Sci. 2022: 102356. https://doi.org/10.1016/j.jksus.2022.102356
  • [24] Mohammed HA, Mohammed SAA, Khan O, Ali HM. Topical eucalyptol ointment accelerates wound healing and exerts antioxidant and anti-inflammatory effects in rats' skin burn model. J Oleo Sci. 2022; 71(12): 1777–1788. https://doi.org/10.5650/jos.ess22214
  • [25] Jiji S, Udhayakumar S, Rose C, Muralidharan C, Kadirvelu K. Thymol enriched bacterial cellulose hydrogel as effective material for third degree burn wound repair. Int J Biol Macromol. 2019;122:452-460. https://doi.org/10.1016/j.ijbiomac.2018.10.192
  • [26] Gushiken LFS, Beserra FP, Hussni MF, Gonzaga MT, Ribeiro VP, de Souza PF, Campos JCL, Massaro TNC, Hussni CA, Takahira RK, Marcato PD, Bastos JK, Pellizzon CH. Beta-caryophyllene as an antioxidant, anti-inflammatory and re-epithelialization activities in a rat skin wound excision model. Oxid Med Cell Longev. 2022;2022:9004014. https://doi.org/10.1155/2022/9004014
  • [27] Amirzade-Iranaq MH, Tajik M, Amirmohammadi M, Yazdi FR, Takzaree N. Topical Mentha piperita effects on cutaneous wound healing: A study on TGF-β expression and clinical outcomes. World J Plast Surg. 2022; 11(1): 86- 96. https://doi.org/10.52547/wjps.11.1.86
  • [28] Barrientos S, Stojadinovic O, Golinko MS, Brem H, Tomic-Canic M. Growth factors and cytokines in wound healing. Wound Repair Regen. 2008; 16(5): 585-601. https://doi.org/10.1111/j.1524-475X.2008.00410.x
  • [29] Lichtman MK, Otero Vinas M, Falanga V. Transforming growth factor beta (TGF β) isoforms in wound healing and fibrosis. Wound Repair Regen. 2016; 24(2): 215-222. https://doi.org/10.1111/wrr.12398
  • [30] Sogabe Y, Abe M, Yokoyama Y, Ishikawa O. Basic fibroblast growth factor stimulates human keratinocyte motility by Rac activation. Wound Repair Regen. 2006; 14(4): 457-462. https://doi.org/10.1111/j.1743-6109.2006.00143.x
  • [31] Garoufalia Z, Papadopetraki A, Karatza E, Vardakostas D, Philippou A, Kouraklis G, Mantas D. Insulin-like growth factor-I and wound healing, a potential answer to non-healing wounds: A systematic review of the literature and future perspectives. Biomed Rep. 2021; 15(2): 66. https://doi.org/10.3892/br.2021.1442
  • [32] Oh JY, Park MA, Kim YC. Peppermint oil promotes hair growth without toxic signs. Toxicol Res. 2014; 30(4): 297-304. https://doi.org/10.5487/TR.2014.30.4.297
  • [33] Mkaddem M, Bouajila J, Ennajar M, Lebrihi A, Mathieu F, Romdhane M. Chemical composition and antimicrobial and antioxidant activities of Mentha (longifolia L. and viridis) essential oils. J Food Sci. 2009; 74(7): 358-363. https://doi.org/10.1111/j.1750-3841.2009.01272.x
  • [34] Eissa TF, González-Burgos E, Carretero ME, Gómez-Serranillos MP. Compositional analysis and in vitro protective activity against oxidative stress of essential oils from Egyptian plants used in traditional medicine. Nat Prod Commun. 2014; 9(9): 1377-1382. https://doi.org/10.1177/1934578X1400900939
  • [35] Dadkhah A, Fatemi F, Rasooli A, Malayeri MRM, Torabi F. Assessing the effect of Mentha longifolia essential oils on COX-2 expression in animal model of sepsis induced by caecal ligation and puncture. Pharm Biol. 2018; 56(1): 495- 504. https://doi.org/10.1080/13880209.2018.1510972
  • [36] Rasooli A, Fatemi F, Hajihosseini R, Vaziri A, Akbarzadeh K, Malayeri MRM, Dini S, Foroutanrad M. Synergistic effects of deuterium depleted water and Mentha longifolia L. essential oils on sepsis-induced liver injuries through regulation of cyclooxygenase-2. Pharm Biol. 2019; 7(1): 125-132. https://doi.org/10.1080/13880209.2018.1563622
  • [37] Coté H, Boucher MA, Pichette A, Legault J. Anti-inflammatory, antioxidant, antibiotic, and cytotoxic activities of Tanacetum vulgare L. essential oil and its constituents. Medicines (Basel). 2017; 4(2): 34. https://doi.org/10.3390/medicines4020034
  • [38] Cai ZM, Peng JQ, Chen Y, Tao L, Zhang YY, Fu LY, Long QD, Shen XC. 1,8-Cineole: a review of source, biological activities, and application. J Asian Nat Prod Res. 2021; 23(10): 938-954. https://doi.org/10.1080/10286020.2020.1839432
  • [39] Bai X, Liu L, Zhang J, Chen L, Wu T, Aisa HA, Maiwulanjiang M. Spectrum-effect relationship between GC-QTOFMS fingerprint and antioxidant, anti-inflammatory activities of Schizonepeta tenuifolia essential oil. Biomed Chromatogr. 2021; 35(7): e5106. https://doi.org/10.1002/bmc.5106
  • [40] Ramsey JT, Shropshire BC, Nagy TR, Chambers KD, Li Y, Korach KS. Essential oils and health. Yale J Biol Med. 2020; 93(2): 291-305.
  • [41] Xiao T, Yan Z, Xiao S, Xia Y. Proinflammatory cytokines regulate epidermal stem cells in wound epithelialization. Stem Cell Res Ther. 2020; 11(1): 232. https://doi.org/10.1186/s13287-020-01755-y
  • [42] Ozkan H, Yanmis D, Karadayi M, Bal T, Baris O, Gulluce M. Determination of genotoxic and antigenotoxic properties of essential oil from Ferula orientalis L. using Ames/Salmonella and E. coli WP2 bacterial test systems. Toxicol Ind Health. 2014; 30(8): 714-723. https://doi.org/10.1177/0748233712462479
  • [43] Nawarathne NW, Wijesekera K, Wijayaratne WMDGB, Napagoda M. Development of novel topical cosmeceutical formulations from Nigella sativa L. with antimicrobial activity against acne-causing microorganisms. Sci World J. 2019; 5985207. https://doi.org/10.1155/2019/5985207
  • [44] Taghizadehghalehjoughi A, Sezen S, Hacimuftuoglu A, Güllüce M. Vincristine combination with Ca+2 channel blocker increases antitumor effects. Mol Biol Rep. 2019; 46(2): 2523–2528. https://doi.org/10.1007/s11033-019-04706- w
  • [45] Premarathna AD, Ranahewa TH, Wijesekera SK, Harishchandra DL, Karunathilake KJK, Waduge RN, Wijesundara RRMKK, Jayasooriya AP, Wijewardana V, Rajapakse RPVJ. Preliminary screening of the aqueous extracts of twenty three different seaweed species in Sri Lanka with in vitro and in-vivo assays. Heliyon. 2020; 6(6): e03918. https://doi.org/10.1016/j.heliyon.2020.e03918
  • [46] Okkay IF, Okkay U, Cicek B, Yilmaz A, Yesilyurt F, Mendil AS, Hacimuftuoglu A. Neuroprotective effect of bromelain in 6-hydroxydopamine induced in vitro model of Parkinson's disease. Mol Biol Rep. 2021; (12): 7711-7717. https://doi.org/10.1007/s11033-021-06779-y
  • [47] Taghizadehghalehjoughi A, Sezen S, Bayram C, Hacimuftuoğlu A, Gulluce M. Investigation of Anti-tumor effect in neuroblastoma cell line; Amlodipine & Metformin. Anatol J Bio. 2020; 1: 16-21.
APA SEZEN S, ERTUĞRUL M, BAYRAM C, özkaraca m, KOÇ T, DEMİR A, Güllüce M, Hacimuftuoglu A (2023). The in-vitro Wound Healing Potential of Essential Oil Extracted from Mentha longifolia L.. , 1220 - 1233. 10.29228/jrp.411
Chicago SEZEN Selma,ERTUĞRUL Muhammed Sait,BAYRAM Cemil,özkaraca mustafa,KOÇ Taha Yasin,DEMİR Abdussamed Yasin,Güllüce Medine,Hacimuftuoglu Ahmet The in-vitro Wound Healing Potential of Essential Oil Extracted from Mentha longifolia L.. (2023): 1220 - 1233. 10.29228/jrp.411
MLA SEZEN Selma,ERTUĞRUL Muhammed Sait,BAYRAM Cemil,özkaraca mustafa,KOÇ Taha Yasin,DEMİR Abdussamed Yasin,Güllüce Medine,Hacimuftuoglu Ahmet The in-vitro Wound Healing Potential of Essential Oil Extracted from Mentha longifolia L.. , 2023, ss.1220 - 1233. 10.29228/jrp.411
AMA SEZEN S,ERTUĞRUL M,BAYRAM C,özkaraca m,KOÇ T,DEMİR A,Güllüce M,Hacimuftuoglu A The in-vitro Wound Healing Potential of Essential Oil Extracted from Mentha longifolia L.. . 2023; 1220 - 1233. 10.29228/jrp.411
Vancouver SEZEN S,ERTUĞRUL M,BAYRAM C,özkaraca m,KOÇ T,DEMİR A,Güllüce M,Hacimuftuoglu A The in-vitro Wound Healing Potential of Essential Oil Extracted from Mentha longifolia L.. . 2023; 1220 - 1233. 10.29228/jrp.411
IEEE SEZEN S,ERTUĞRUL M,BAYRAM C,özkaraca m,KOÇ T,DEMİR A,Güllüce M,Hacimuftuoglu A "The in-vitro Wound Healing Potential of Essential Oil Extracted from Mentha longifolia L.." , ss.1220 - 1233, 2023. 10.29228/jrp.411
ISNAD SEZEN, Selma vd. "The in-vitro Wound Healing Potential of Essential Oil Extracted from Mentha longifolia L.". (2023), 1220-1233. https://doi.org/10.29228/jrp.411
APA SEZEN S, ERTUĞRUL M, BAYRAM C, özkaraca m, KOÇ T, DEMİR A, Güllüce M, Hacimuftuoglu A (2023). The in-vitro Wound Healing Potential of Essential Oil Extracted from Mentha longifolia L.. Journal of research in pharmacy (online), 27(3), 1220 - 1233. 10.29228/jrp.411
Chicago SEZEN Selma,ERTUĞRUL Muhammed Sait,BAYRAM Cemil,özkaraca mustafa,KOÇ Taha Yasin,DEMİR Abdussamed Yasin,Güllüce Medine,Hacimuftuoglu Ahmet The in-vitro Wound Healing Potential of Essential Oil Extracted from Mentha longifolia L.. Journal of research in pharmacy (online) 27, no.3 (2023): 1220 - 1233. 10.29228/jrp.411
MLA SEZEN Selma,ERTUĞRUL Muhammed Sait,BAYRAM Cemil,özkaraca mustafa,KOÇ Taha Yasin,DEMİR Abdussamed Yasin,Güllüce Medine,Hacimuftuoglu Ahmet The in-vitro Wound Healing Potential of Essential Oil Extracted from Mentha longifolia L.. Journal of research in pharmacy (online), vol.27, no.3, 2023, ss.1220 - 1233. 10.29228/jrp.411
AMA SEZEN S,ERTUĞRUL M,BAYRAM C,özkaraca m,KOÇ T,DEMİR A,Güllüce M,Hacimuftuoglu A The in-vitro Wound Healing Potential of Essential Oil Extracted from Mentha longifolia L.. Journal of research in pharmacy (online). 2023; 27(3): 1220 - 1233. 10.29228/jrp.411
Vancouver SEZEN S,ERTUĞRUL M,BAYRAM C,özkaraca m,KOÇ T,DEMİR A,Güllüce M,Hacimuftuoglu A The in-vitro Wound Healing Potential of Essential Oil Extracted from Mentha longifolia L.. Journal of research in pharmacy (online). 2023; 27(3): 1220 - 1233. 10.29228/jrp.411
IEEE SEZEN S,ERTUĞRUL M,BAYRAM C,özkaraca m,KOÇ T,DEMİR A,Güllüce M,Hacimuftuoglu A "The in-vitro Wound Healing Potential of Essential Oil Extracted from Mentha longifolia L.." Journal of research in pharmacy (online), 27, ss.1220 - 1233, 2023. 10.29228/jrp.411
ISNAD SEZEN, Selma vd. "The in-vitro Wound Healing Potential of Essential Oil Extracted from Mentha longifolia L.". Journal of research in pharmacy (online) 27/3 (2023), 1220-1233. https://doi.org/10.29228/jrp.411
Sayfa Oluşturulma Tarihi
24-04-2024 7:47

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