TY  - JOUR
TI  - The in-vitro Wound Healing Potential of Essential Oil  Extracted from Mentha longifolia L.
AB  - Products from Mentha species are widely used in medical applications, including wound healing, due to  the bioactive compounds they may contain. However, data on the effect of Mentha longifolia L. on wound healing are  limited. This study investigated the antimicrobial and wound healing-promoting effects of Mentha longifolia L. essential  oil using in vitro methods. The chemical compositions of the essential oil were identified using gas  chromatography/mass spectrometry, while the agar well diffusion and disk diffusion methods were used to determine  antimicrobial activity against pathogenic strains. A scratch wound healing assay was performed following  determination of the cytotoxic dose in human fibroblast cell lines. The media were used for biochemical analysis 48 h  after the in vitro wound model. Immunohistochemical staining was applied to determine the contribution of the  essential oil to wound healing. The essential oil exhibited varying levels of antimicrobial activity against the tested  pathogens and increased cell viability. All doses in the scratch wound healing assay promoted wound closure in a  shorter time than in the control group. TAC levels were higher in the treated groups than in the control group, while  TOS, IL-6, and TNF-α levels were lower. Levels of expression of FGF 2, IGF, and TGF-β were higher in the treated  groups than in the control group at increasing doses. The essential oil of Mentha longifolia L. exhibited antimicrobial  effects and improved wound healing at doses of 5 µg/mL and 10 µg/mL.
AU  - SEZEN, Selma
AU  - özkaraca, mustafa
AU  - Hacimuftuoglu, Ahmet
AU  - Güllüce, Medine
AU  - ERTUĞRUL, Muhammed Sait
AU  - BAYRAM, Cemil
AU  - KOÇ, Taha Yasin
AU  - DEMİR, Abdussamed Yasin
DO  - 10.29228/jrp.411
PY  - 2023
JO  - Journal of research in pharmacy (online)
VL  - 27
IS  - 3
SN  - 2630-6344
SP  - 1220
EP  - 1233
DB  - TRDizin
UR  - http://search/yayin/detay/1179499
ER  -