TY  - JOUR
TI  - The in vivo Activity of Fraxinus angustifolia in Pain and  Inflammation- Examination of the Biological Activities of  the Sub-extracts in Mice
AB  - Fraxinus species (Oleaceae) are commonly used in the treatment of several inflammatory conditions with  pain, such as rheumatism, arthritis, and gout in folk medicine. We aimed to evaluate this ethnobotanical claim through  in vivo experiments. The n-hexane, dichloromethane, ethyl acetate and water subextracts were obtained from the  methanolic extract, which was prepared from the bark of Fraxinus angustifolia Vahl. The antinociceptive and anti inflammatory activities of extracts were evaluated in mice by hot plate and formalin-induced edema assays,  respectively. Mice were treated with 5-100 mg/kg methanol crude extract and 100 mg/kg subextracts intraperitoneally.  Administration of methanol extract decreased paw thickness in doses of 25 and 100 mg/kg. Water and ethyl acetate  subextracts decreased paw thickness while water subextract also decreased paw volume compared with the control.  Paw thickness values in the dichloromethane and n-hexane subextract groups and paw volume values in the ethyl  acetate, dichloromethane, and n-hexane subextract groups were comparable to those in the control group. The latency  values were higher in the groups treated with the dichloromethane and n-hexane subextracts than in the control group  while the other subextracts did not change the latency values compared to the control group in the hot plate test. In  conclusion, the cortex of Fraxinus angustifolia exhibited a significant in vivo anti-inflammatory and antinociceptive  activity.
AU  - SEVGİ, Serhat
AU  - Sezen, Feride Sena
AU  - DUMAN, Mine
AU  - YAŞAR, Yeşim KAYA
AU  - NALBANTOĞLU, İrem ÇAVUŞOĞLU
AU  - RENDA, GULIN
DO  - 10.29228/jrp.414
PY  - 2023
JO  - Journal of research in pharmacy (online)
VL  - 27
IS  - 3
SN  - 2630-6344
SP  - 1252
EP  - 1259
DB  - TRDizin
UR  - http://search/yayin/detay/1179520
ER  -