TY  - JOUR
TI  - Recurrence Patterns in NSCLC Patients Treated with Post-operative Radiotherapy; Turkish Radiation Oncology Society Thoracic Oncology Group Study
AB  - OBJECTIVE Post-operative radiotherapy (PORT) in non-small cell lung cancer (NSCLC), especially after complete resection, has long been an unresolved dilemma and debated among therapeutic disciplines. We aimed to evaluate the effects of different radiotherapy volumes and techniques on local-regional recurrence patterns and PORT results in patients with NSCLC. METHODS The results of 389 patients who underwent surgery and received PORT at 11 centers were analyzed retrospectively. The surgical margin was positive or closes in 100 (26%) patients. The PORT dose was a median of 50 Gy (36–60 Gy). Intensity-modulated RT methods were used in 68 (17.5%) patients. RESULTS The first recurrence of the patients who developed relapse, local recurrence was found in 77 (19.8%) patients, distant recurrence was found in 95 (24%) patients, and both recurrences was found in 30 (8%) patients. The median time to locoregional relapse was 14 months (1.84–59.7 months). Local-regional recurrence was not significantly higher in patients with positive surgical margins than in negative patients (39% vs. 29%, p=0.1), but the dose administered to these patients was also higher. Mediastinal recurrence occurred in 28 (19%) patients who did not receive radiotherapy to the mediastinum; 25 of these recurrences (89%) were just near or outside the field. Cardiac events became 7% in all groups and did not change according to chosen mediastinal radiotherapy volume. CONCLUSION A clear description of the PORT volumes according to the localization of the primary tumor and the involved lymph nodes would be beneficial in terms of establishing the recurrence/toxicity balance better.
AU  - Akyürek, Serap
AU  - BAYIR ANGIN, GÜLDEN
AU  - Elmas, Özlem
AU  - Sert, Fatma
AU  - Yalman, Deniz
AU  - Barlas, Ceren
AU  - benli yavuz, berrin
AU  - GÜMÜSTEPE, ESRA
AU  - DINCBAS, HIDAYET FAZILET
AU  - Ozen, Alaattin
AU  - Korkmaz Kirakli, Esra
AU  - Tepetam, Hüseyin
AU  - KARABULUT GÜL, SULE
AU  - KOCAK, ZAFER
AU  - Demiral, Ayşe
AU  - Bakkal, Bekir Hakan
AU  - Cukurcayir, Funda
AU  - Erdem, Sevilay
AU  - Yakar, Melek
AU  - Kanyilmaz, Gul
AU  - Umay, Cenk
AU  - Ergen, Sefika Arzu
AU  - Yılmaz, Hasan
AU  - Saynak, Mert
DO  - 10.5505/tjo.2023.3921
PY  - 2023
JO  - Türk Onkoloji Dergisi
VL  - 38
IS  - 2
SN  - 1300-7467
SP  - 136
EP  - 144
DB  - TRDizin
UR  - http://search/yayin/detay/1179626
ER  -