Yıl: 2023 Cilt: 28 Sayı: 2 Sayfa Aralığı: 232 - 236 Metin Dili: İngilizce DOI: 10.5505/ejm.2023.81236 İndeks Tarihi: 06-06-2023

Examination of The Relationship Between Intermittent Fasting and Irisine Levels In Rats Fed A High-Fat Diet

Öz:
In this study, the relationship between intermittent fasting and irisin levels has been examined in rats fed on a high -fat diet. Eighteen Wistar albino rats were randomly divided into three groups as control, high -fat diet (HFD) and, high-fat diet+intermittent fasting (HFD+IF) (n=6). After 8 weeks of study irisin level were measured in serum. Irisin levels in the HFD group were lower (8.24 ng/ml) than the control (10.50 ng/ml) but in the HFD+IF group was higher (12.25 ng/ml) compared to the HFD group (8.24 ng/ml) (P<0.05). It was observed that body weight in the HFD group was higher (385.92 g) than the control group (270.50 g) and was lower (297.71 g) in the HFD+IF group compared to the HFD group (385.92 g) (P<0.05). As a result, it has been seen that intermittent fasting increases the level of irisin and causes weight loss, and it is conclu ded that it can be evaluated among the methods to be used in the treatment and prevention of obesity.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
  • 1. Jonquil MP, Flavia Souza-S, Shawn J M, et al. High fat diet consumption differentially affects adipose tissue inflammation and adipocyte size in obesity-prone and obesity resistant rats. Int J Obes (Lond). 2018 ; 42(3): 535–541.
  • 2. Day SD,Enos RT,Mc Clellan LJ, et al. Linking inflammation to tumorigenesis in a mouse model of high-fat-diet- enhanced colon cancer. Cytokine. 2013; 64: 454-462.
  • 3. Caballero B. The global epidemic of obesity: An overview. Epidemiol Rev 2007; 29:1–5.
  • 4. Lu J, Bi Y, Ning G. Curbing the obesity epidemic in China. Lancet Diabetes Endocrinol. 2016; 4: 470–471.
  • 5. Van devijvere S,Chow CC, Hall KD, et al. Increased food energy supply as a majör driver of the obesity epidemic: a global analysis. Bull. World Health Organ 2015; 93: 446–456.
  • 6. Studentsova V, Mora KM, Glasner MF, et al. Obesity/Type II diabetes promotes function-limiting changes in murine tendons that are not reversed by estoring normal metabolic function. Sci. Rep 2018; 8: 9218.
  • 7. Zimmerman B, Kundu P, Rooney WD, et al.The Effect of High Fat Diet on Cerebrovascular Health and Pathology: A Species Comparative Review Molecules. 2021; 26(11): 3406.
  • 8. Hariri N, Thibault L. High-fat diet-induced obesity in animal models. Nutr Res Rev 2010; 23(2):270-99.
  • 9. Beulen Y, Martínez-González MA, van de Rest O, et al . Quality of Dietary Fat Intake and Body Weight and Obesity in a Mediterranean Population: Secondary Analyses within the PREDIMED Trial. Nutrients 2018:10 (12); PMC6315420.
  • 10. Dewhurst-Trigg R , Hulston CJ, Markey O.The effect of quantity and quality of dietary fat intake on subcutaneous white adipose tissue inflammatory responses. Proc Nutr Soc. 2020; 17;1-15.
  • 11. Rosengren A, and Lissner L.Thesociology of obesity. In Obesity and Metabolism, 2008; pp. 260–270.
  • 12. Bhandari U, Kumar V, Khanna N, et al. The effect of high-fat diet-induced obesity on cardiovascular toxicity in wistar albino rats. Human and Experimental Toxicology 2010;30:1313–1321.
  • 13. Phillips CM , Kesse-Guyot E, McManus R, et al.High dietary saturated fat intake accentuates obesity risk associated with the fat mass and obesity-associated gene in adults. J Nutr 2012;142 (5):824-31.
  • 14. Wang L , Wang H, Zhang B, et al. Elevated Fat Intake Increases Body Weight and the Risk of Overweight and Obesity among Chinese Adults: 1991-2015 Trends Nutrients 2020 26;12(11):3272.
  • 15. Hill JO, Wyatt HR, Peters JC. Energy balance and obesity. Circulation. 2012;126:126-32.
  • 16. Harvie NM, Pegington M, Mattson MP, et al. The effects of intermittent or continuous energy restriction on weight loss and metabolic disease risk markers: a randomized trial in young overweight women. Int J Obes 2011;35:714-27.
  • 17. Varady KA, Bhutani S, Church EC, et al. Short-term modified alternate-day fasting: a novel dietary strategy for weightloss and cardioprotection in obese adults. Am J Clin Nutr 2009;90:1138-43.
  • 18. Varady KA. Intermittent versus Daily calorie restriction: which diet regimen is more effective for weight loss? Obes Rev 2011;12: 593-601.
  • 19. Varady KA, Hellerstein MK. Alternate-day fasting and chronic disease prevention: a review of human and animal trials. Am J Clin Nutr 2007; 86:7-13.
  • 20. Günbatar N, Bayıroğlu F. Ratlarda yüksek oranda doymuş yağlı diyet ile aralıklı beslemenin deneysel kolon kanseri gelişimi ve bazı serum inflamasyon markırları üzerine etkisi. Y.Y.Ü. Sağlık Bilimleri Enstitüsü Veteriner Fakültesi Fizyoloji Ana Bilim Dalı Doktora Tezi, Van, 2014.
  • 21. Kartinah NT, Sianipar IR, Nafi'ah, and Rabia .The Effects of Exercise Regimens on Irisin Levels in Obese Rats Model: Comparing High-Intensity Intermittent with Continuous Moderate- Intensity Training.Biomed Res Int. 2018 Dec 27;2018:4708287. doi: 10.1155/2018/4708287. E Collection 2018.
  • 22. Elsen M, Raschke S, and Eckel J. Browning of White fat: does irisin play a role in humans. J of Endoc 2014; 222: 25-38.
  • 23. Bostrom P,Wu J, Jedrychowski, M, et al. A PGC1-α-dependen tmyokine that drives brown-fat-like development of White fat and thermogenesis. Nature 2012;481:463–468.
  • 24. Roca-Rivada A, Castelao C, Senin LL, et al. FNDC5/irisin is not only a myokine but also an adipokine. PLoSOne, 2013; 8:4:e60563.
  • 25. Villarroya F. Irisin, turning up the heat. Cell Metab 2012; 15: 277–278.
  • 26. Lanzi CR , Perdicaro DJ, Tudela JG, et al. Grape pomace extract supplementation activates FNDC5/irisin in muscle and promotes white adipose browning in rats fed a high-fat diet. FoodFunct. 2020; 26:1537-1546.
  • 27. Niranjan SB, Belwalkar SV, Tambe S, et al. Recombinant irisin inducesweightloss in highfat DIO micethroughincrease in energy consumption and thermogenesis. Biochem Biophys Res Commun 2019;519:422–429.
  • 28. Mazur-Bialy A, Bilski J, Wojcik D, et al. Beneficial. Effect of Voluntary Exercise on Experimental Colitis in Mice Fed a High- FatDiet: The Role of Irisin, Adiponectin and Proinflammatory Biomarkers. Nutrients. 2017; 9:4,410.
  • 29. Jimenez-Aranda A, Fernández-VázquezG, Campos D, et al. Melatonin induces browning of inguinal White adipose tissue in Zucker diabetic fatty rats. J. Pineal. Res 2013;55: 416– 423.
  • 30. Kang YS, Kim JC, Kim JS et al. Effects of Swimming Exercise on Serum Irisin and Bone FNDC5 in Rat Models of High-Fat Diet- Induced Osteoporosis. J of Sport Sciand Med 2019; 18: 596-603.
  • 31. Lu Y, Li H, Shen SW, et al. Swimming exercise increases serum irisin level and reduces body fatmass in high fat-diet fed Wistar rats. Lipids in Health and Disease 2016; 15:93.
  • 32. Moreno-Navarrete JM, Ortega F, Serrano M, et al. Irisin is expressed and produced by human muscle and adipose tissue in association with obesity and insülin resistance. J Clin Endocrinol Metab 2013; 98: 769-778.
  • 33. de Macedo SM, de Fariaslelis D, Mendes KL, et al, Effects of Dietary Macro nutrient Composition on FNDC5 andIrisin in Mice Skeletal Muscle. Metab Syndr Relat Disord, 2017; 15: 161-169.
  • 34. Schlog M, Piaggi,Votruba SB, et al. Increased 24 hour ad libitum food intake is associated with lower plasma irisin concentrations the following morning in adult humans. Appetite 2015; 90:154–159.
  • 35. Srinivasa S, Suresh C, Mottla J, et al. FNDC5 relates to skeletal muscle IGF I and mitochondrial function and gene expression in obese men with reduced growth hormone. Growth Horm. IGF Res. 2016; 26:36–41.
  • 36. Stengel A, Hofmann T, Goebel Stengel M, et al. Circulating levels of irisin in patients with anorexia nervosa and different stages of obesity–correlation with body mass index. Peptides 2013; 39:125–130.
  • 37. Karras SN, Koufakis T, Adamidou L, et al.Effects of Christian Orthodox Fasting Versus Time-Restricted Eating on Plasma Irisin Concentrations Among Overweight Metabolically Healthy Individuals.Nutrients 2021; 13: 4, 1071.
  • 38. Alzoughool F, Al Hourani H, Atoum M, et al. Irisin leptin and adiponectin levels are reduced significantly during fasting. Mediterr J. Nutr. Metab2019;4:389–396.
  • 39. Crujeiras AB, Zulet MA, Lopez-Legarrea P, et al. Association between circulating irisin levels and the promotion of insülin resistance during the weight maintenance period after a dietary weight-lowering program in obese patients. Metabolism 2014; 63: 520-531.
  • 40. Huerta AE, Prieto-Hontoria PL, Fernandez- Galilea M, et al. Circulating irisin and glucose metabolism in over weight/obese women: effects of α lipoicacid and eicosapentaenoic acid. J physiolbiochem 2015; 71: 547-558.
  • 41. de la Iglesia R, Lopez Legarrea P, Crujeiras AB, et al. Plasma irisin depletion under energy restriction is associated with improvements in lipid profile in metabolic syndrome patients. Clin endocrinol 2014;81.306-311.
  • 42. Erickson HP. Irisinand FNDC5 in retrospect: An exercise hormone or a trans membrane receptor? Adipocyte, 2013;2: 289-293.
  • 43. Albrecht, E, Norheim F, Thiede B, et al. Irisin - a myth rather than an exercise-inducible myokine. Sci Rep, 2015;9: 5, 8889.
APA günbatar N, Bulduk B (2023). Examination of The Relationship Between Intermittent Fasting and Irisine Levels In Rats Fed A High-Fat Diet. , 232 - 236. 10.5505/ejm.2023.81236
Chicago günbatar Nizamettin,Bulduk Bahattin Examination of The Relationship Between Intermittent Fasting and Irisine Levels In Rats Fed A High-Fat Diet. (2023): 232 - 236. 10.5505/ejm.2023.81236
MLA günbatar Nizamettin,Bulduk Bahattin Examination of The Relationship Between Intermittent Fasting and Irisine Levels In Rats Fed A High-Fat Diet. , 2023, ss.232 - 236. 10.5505/ejm.2023.81236
AMA günbatar N,Bulduk B Examination of The Relationship Between Intermittent Fasting and Irisine Levels In Rats Fed A High-Fat Diet. . 2023; 232 - 236. 10.5505/ejm.2023.81236
Vancouver günbatar N,Bulduk B Examination of The Relationship Between Intermittent Fasting and Irisine Levels In Rats Fed A High-Fat Diet. . 2023; 232 - 236. 10.5505/ejm.2023.81236
IEEE günbatar N,Bulduk B "Examination of The Relationship Between Intermittent Fasting and Irisine Levels In Rats Fed A High-Fat Diet." , ss.232 - 236, 2023. 10.5505/ejm.2023.81236
ISNAD günbatar, Nizamettin - Bulduk, Bahattin. "Examination of The Relationship Between Intermittent Fasting and Irisine Levels In Rats Fed A High-Fat Diet". (2023), 232-236. https://doi.org/10.5505/ejm.2023.81236
APA günbatar N, Bulduk B (2023). Examination of The Relationship Between Intermittent Fasting and Irisine Levels In Rats Fed A High-Fat Diet. Eastern Journal of Medicine, 28(2), 232 - 236. 10.5505/ejm.2023.81236
Chicago günbatar Nizamettin,Bulduk Bahattin Examination of The Relationship Between Intermittent Fasting and Irisine Levels In Rats Fed A High-Fat Diet. Eastern Journal of Medicine 28, no.2 (2023): 232 - 236. 10.5505/ejm.2023.81236
MLA günbatar Nizamettin,Bulduk Bahattin Examination of The Relationship Between Intermittent Fasting and Irisine Levels In Rats Fed A High-Fat Diet. Eastern Journal of Medicine, vol.28, no.2, 2023, ss.232 - 236. 10.5505/ejm.2023.81236
AMA günbatar N,Bulduk B Examination of The Relationship Between Intermittent Fasting and Irisine Levels In Rats Fed A High-Fat Diet. Eastern Journal of Medicine. 2023; 28(2): 232 - 236. 10.5505/ejm.2023.81236
Vancouver günbatar N,Bulduk B Examination of The Relationship Between Intermittent Fasting and Irisine Levels In Rats Fed A High-Fat Diet. Eastern Journal of Medicine. 2023; 28(2): 232 - 236. 10.5505/ejm.2023.81236
IEEE günbatar N,Bulduk B "Examination of The Relationship Between Intermittent Fasting and Irisine Levels In Rats Fed A High-Fat Diet." Eastern Journal of Medicine, 28, ss.232 - 236, 2023. 10.5505/ejm.2023.81236
ISNAD günbatar, Nizamettin - Bulduk, Bahattin. "Examination of The Relationship Between Intermittent Fasting and Irisine Levels In Rats Fed A High-Fat Diet". Eastern Journal of Medicine 28/2 (2023), 232-236. https://doi.org/10.5505/ejm.2023.81236