Yıl: 2023 Cilt: 28 Sayı: 2 Sayfa Aralığı: 314 - 319 Metin Dili: İngilizce DOI: 10.5505/ejm.2023.18853 İndeks Tarihi: 06-06-2023

Is the Multifocality Rate in Thyroid Cancer Patients Increasing Over the Years

Öz:
Papillary thyroid cancer (PTC) is the most common type of thyroid cancer, and its inciden ce continues to increase. Multifocality is common in PTC, and it has been suggested in many studies that multifocality may be associated with poor prognosis. In this study, data of patients followed with multifocal PTC were evaluated. Following the approval of the local ethics committee, the data of patients who received total thyroidectomy and subsequent radioactive iodine (RAI) treatment for thyroid cancer between 2012 and 2020 were evaluated. Multifocality was detected in 142 (19.88%) of the 714 PTC patients studied. The rate of multifocality among PTC patients was 3.29% in 2012, 7.2% in 2013, 10.1% in 2014, 10.5% in 2015, 38.15% in 2016, 31.6% in 2017, 33.33% in 2018, 32.58% in 2019 and 22.22% in 2020. Of these patients, 52.1% had 2 foci, 20.4% had 3 foc i, 15.5% had 4 foci, and 12% had 5 or more foci. Multifocality was observed in the right and left lobe in 54.2% of the patients, the right lobe in 21.1% of the patients and t he left lobe in 12.7% of the patients. Multifocality was not detected in the isthm us only. It was found that as the number of tumor foci increased, differentiation decreased. It was observed that multifocality was more common in microcarcinomas. In our clinic, it has been observed that the rate of multifocal PTC has increased in recent years. This significant increase may be the result of morphological changes as well as improvements in diagnosis and treatment.
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  • 1. Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: a cancer journal for clinicians 2021.
  • 2. Feng J-W, Qu Z, Qin A-C, Pan H, Ye J, Jiang Y. Significance of multifocality in papillary thyroid carcinoma. European Journal of Surgical Oncology 2020;46:1820-8.
  • 3. So YK, Kim MW, Son YI. Multifocality and bilaterality of papillary thyroid microcarcinoma. Clin Exp Otorhinolaryngol 2015;8:174-8.
  • 4. Harries V, Wang LY, McGill M, Xu B, Tuttle RM, Wong RJ, et al. Should multifocality be an indication for completion thyroidectomy in papillary thyroid carcinoma? Surgery 2020;167:10-17.
  • 5. Monzón MA, Oleaga AA, Leyre MMA, Merlo PI, Etxeberria ME, Paja FM. Association between multifocality and aggressive histopathological findings in papillary thyroid cancer. 22nd European Congress of Endocrinology: BioScientifica; 2020.
  • 6. Lu Z, Sheng J, Zhang Y, Deng J, Li Y, Lu A, et al. Clonality analysis of multifocal papillary thyroid carcinoma by using genetic profiles. The Journal of Pathology 2016;239:72-83.
  • 7. Park SY, Park YJ, Lee YJ, Lee HS, Choi SH, Choe G, et al. Analysis of differential BRAFV600E mutational status in multifocal papillary thyroid carcinoma. Cancer 2006;107:1831-1838.
  • 8. Mitchell A, Gandhi A, Scott-Coombes D, Perros P. Management of thyroid cancer: United Kingdom national multidisciplinary guidelines. The Journal of Laryngology & Otology 2016;130:S150-S160.
  • 9. Joseph KR, Edirimanne S, Eslick GD. Multifocality as a prognostic factor in thyroid cancer: A meta-analysis. International Journal of Surgery 2018;50:121-125.
  • 10. Wang F, Yu X, Shen X, Zhu G, Huang Y, Liu R, et al. The Prognostic Value of Tumor Multifocality in Clinical Outcomes of Papillary Thyroid Cancer. The Journal of Clinical Endocrinology & Metabolism 2017;102:3241- 3250.
  • 11. Markovic I, Goran M, Besic N, Buta M, Djurisic I, Stojiljkovic D, et al. Multifocality as independent prognostic factor in papillary thyroid cancer - A multivariate analysis. J buon 2018;23:1049-1054.
  • 12. Cooper DS, Doherty GM, Haugen BR, Kloos RT, Lee SL, Mandel SJ, et al. Revised American thyroid association management guidelines for patients with thyroid nodules and differentiated thyroid cancer. Thyroid 2009;19:1167-1214.
  • 13. Wang X, Zhu J, Li Z, Wei T. The benefits of radioactive iodine ablation for patients with intermediate-risk papillary thyroid cancer. PLOS ONE 2020;15:e0234843.
  • 14. Iyer NG, Morris LG, Tuttle RM, Shaha AR, Ganly I. Rising incidence of second cancers in patients with low risk (T1N0) thyroid cancer who receive radioactive iodine therapy. Cancer 2011;117:4439-4446.
  • 15. Geron Y, Benbassat C, Shteinshneider M, Or K, Markus E, Hirsch D, et al. Multifocality is not an independent prognostic factor in papillary thyroid cancer: a propensity score– matching analysis. Thyroid 2019;29:513-522.
  • 16. Haugen BR, Alexander EK, Bible KC, Doherty GM, Mandel SJ, Nikiforov YE, et al. 2015 American Thyroid Association Management Guidelines for Adult Patients with Thyroid Nodules and Differentiated Thyroid Cancer: The American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer. Thyroid 2016;26:1-133.
  • 17. Malandrino P, Pellegriti G, Attard M, Violi MA, Giordano C, Sciacca L, et al. Papillary thyroid microcarcinomas: a comparative study of the characteristics and risk factors at presentation in two cancer registries. The Journal of Clinical Endocrinology & Metabolism 2013;98:1427-1434.
  • 18. Karatzas T, Vasileiadis I, Charitoudis G, Karakostas E, Tseleni-Balafouta S, Kouraklis G. Bilateral versus unilateral papillary thyroid microcarcinoma: predictive factors and associated histopathological findings following total thyroidectomy. Hormones 2013;12:529- 536.
  • 19. Bentrem DJ, Angelos P, Talamonti MS, Nayar R. Is preoperative investigation of the thyroid justified in patients undergoing parathyroidectomy for hyperparathyroidism? Thyroid 2002;12:1109-1112.
  • 20. Evranos B, Polat SB, Cuhaci FN, Baser H, Topaloglu O, Kilicarslan A, et al. A cancer of undetermined significance: Incidental thyroid carcinoma. Diagnostic Cytopathology 2019;47:412-416.
  • 21. Polat SB, Cakir B, Evranos B, Baser H, Cuhaci N, Aydin C, et al. Preoperative predictors and prognosis of bilateral multifocal papillary thyroid carcinomas. Surgical oncology 2019;28:145-149.
  • 22. Díez JJ, Alcázar V, Iglesias P, Romero-Lluch A, Sastre J, Corral BP, et al. Thyroid lobectomy in patients with differentiated thyroid cancer: an analysis of the clinical outcomes in a nationwide multicenter study. Gland surgery 2021;10:678-689.
APA gömeç m, Gedikli M, Ertürk S, HASBEK Z (2023). Is the Multifocality Rate in Thyroid Cancer Patients Increasing Over the Years. , 314 - 319. 10.5505/ejm.2023.18853
Chicago gömeç muhammed,Gedikli Mustafa Asım,Ertürk Seyit Ahmet,HASBEK Zekiye Is the Multifocality Rate in Thyroid Cancer Patients Increasing Over the Years. (2023): 314 - 319. 10.5505/ejm.2023.18853
MLA gömeç muhammed,Gedikli Mustafa Asım,Ertürk Seyit Ahmet,HASBEK Zekiye Is the Multifocality Rate in Thyroid Cancer Patients Increasing Over the Years. , 2023, ss.314 - 319. 10.5505/ejm.2023.18853
AMA gömeç m,Gedikli M,Ertürk S,HASBEK Z Is the Multifocality Rate in Thyroid Cancer Patients Increasing Over the Years. . 2023; 314 - 319. 10.5505/ejm.2023.18853
Vancouver gömeç m,Gedikli M,Ertürk S,HASBEK Z Is the Multifocality Rate in Thyroid Cancer Patients Increasing Over the Years. . 2023; 314 - 319. 10.5505/ejm.2023.18853
IEEE gömeç m,Gedikli M,Ertürk S,HASBEK Z "Is the Multifocality Rate in Thyroid Cancer Patients Increasing Over the Years." , ss.314 - 319, 2023. 10.5505/ejm.2023.18853
ISNAD gömeç, muhammed vd. "Is the Multifocality Rate in Thyroid Cancer Patients Increasing Over the Years". (2023), 314-319. https://doi.org/10.5505/ejm.2023.18853
APA gömeç m, Gedikli M, Ertürk S, HASBEK Z (2023). Is the Multifocality Rate in Thyroid Cancer Patients Increasing Over the Years. Eastern Journal of Medicine, 28(2), 314 - 319. 10.5505/ejm.2023.18853
Chicago gömeç muhammed,Gedikli Mustafa Asım,Ertürk Seyit Ahmet,HASBEK Zekiye Is the Multifocality Rate in Thyroid Cancer Patients Increasing Over the Years. Eastern Journal of Medicine 28, no.2 (2023): 314 - 319. 10.5505/ejm.2023.18853
MLA gömeç muhammed,Gedikli Mustafa Asım,Ertürk Seyit Ahmet,HASBEK Zekiye Is the Multifocality Rate in Thyroid Cancer Patients Increasing Over the Years. Eastern Journal of Medicine, vol.28, no.2, 2023, ss.314 - 319. 10.5505/ejm.2023.18853
AMA gömeç m,Gedikli M,Ertürk S,HASBEK Z Is the Multifocality Rate in Thyroid Cancer Patients Increasing Over the Years. Eastern Journal of Medicine. 2023; 28(2): 314 - 319. 10.5505/ejm.2023.18853
Vancouver gömeç m,Gedikli M,Ertürk S,HASBEK Z Is the Multifocality Rate in Thyroid Cancer Patients Increasing Over the Years. Eastern Journal of Medicine. 2023; 28(2): 314 - 319. 10.5505/ejm.2023.18853
IEEE gömeç m,Gedikli M,Ertürk S,HASBEK Z "Is the Multifocality Rate in Thyroid Cancer Patients Increasing Over the Years." Eastern Journal of Medicine, 28, ss.314 - 319, 2023. 10.5505/ejm.2023.18853
ISNAD gömeç, muhammed vd. "Is the Multifocality Rate in Thyroid Cancer Patients Increasing Over the Years". Eastern Journal of Medicine 28/2 (2023), 314-319. https://doi.org/10.5505/ejm.2023.18853