Yıl: 2023 Cilt: 28 Sayı: 2 Sayfa Aralığı: 369 - 377 Metin Dili: İngilizce DOI: 10.5505/ejm.2023.84758 İndeks Tarihi: 06-06-2023

Autologous Platelet Concentrates: Their Generations, Forms, Preparation Protocols and Roles in Periodontal Regeneration

Öz:
The application of autologous platelet concentrates in wound healing and tissue regeneration, especially in the field of dentistry has been developing with time. There are different methods to produce various forms of autologous p latelet concentrates by changing centrifugation speed and time used during preparation and, of course, there is a difference in regeneration capacity according to preparation protocol. In general, autologous platelet concentrates contain various growth factors such as platelet-derived growth factor (PDGF), vascular endothelial growth factor (VEGF), epidermal growth factor (EGF), insulin-like growth factors (IGF) and transforming growth factor (TGF-β) which are considered a key factor in the contribution of periodontal soft and hard tissue regeneration. Autologous platelet concentrates have become more efficient in periodontal and implant surgery due to their positive effects in heal ing acceleration and new soft and hard tissue formation capability in addition to their other favorable advantages, being inexpensive, timesaving and completely taken from patient. The aim of this review article is to briefly explain the forms and generati ons of autologous platelet concentrates, their applications, potential role in periodontal regeneration, and to compare between their uses, efficiency and preparation methods to qualify clinicians to use them properly according to the case to achieve bette r results.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Derleme Erişim Türü: Erişime Açık
  • 1. Mani R, Mahantesha S, Nandini T., Lavanya R. Growth Factors in Periodontal Regeneration. J Adv Oral Res. 2014;5(2):1-5.
  • 2. Newman P, Michael G, Takei, Henry H, Klokkevold, Perry R. Newman and Carranza’s Clinical Periodontology Thirteenth Edition. J. Chem. Inf. Model. 2017;53(9):1689-1699.
  • 3. Bosshardt DD. The periodontal pocket: pathogenesis, histopathology and consequences. Periodontol 2000. 2018;76(1):43-50.
  • 4. Kanoriya D, Pradeep AR, Singhal S, Garg V, Guruprasad CN. Synergistic Approach Using Platelet-Rich Fibrin and 1% Alendronate for Intrabony Defect Treatment in Chronic Periodontitis: A Randomized Clinical Trial. J Periodontol. 2016;87(12):1427-1435.
  • 5. Heitz-Mayfield LJA, Lang NP. Surgical and nonsurgical periodontal therapy. Learned and unlearned concepts. Periodontol 2000. 2013;62(1):218-231.
  • 6. Martande SS, Kumari M, Pradeep AR, Singh SP, Suke DK, Guruprasad CN. Platelet-Rich Fibrin Combined With 1.2% Atorvastatin for Treatment of Intrabony Defects in Chronic Periodontitis: A Randomized Controlled Clinical Trial. J Periodontol. 2016;87(9):1039-1046.
  • 7. Cortellini P, Tonetti MS. Clinical concepts for regenerative therapy in intrabony defects. Periodontol 2000. 2015;68(1):282-307.
  • 8. Chadwick JK, Mills MP, Mealey BL. Clinical and Radiographic Evaluation of Demineralized Freeze- Dried Bone Allograft Versus Platelet-Rich Fibrin for the Treatment of Periodontal Intrabony Defects in Humans. J Periodontol. 2016;87(11):1253-1260.
  • 9. Crespi R, Capparè P, Gherlone E. Magnesium- Enriched Hydroxyapatite Compared to Calcium Sulfate in the Healing of Human Extraction Sockets: Radiographic and Histomorphometric Evaluation at 3 Months. J Periodontol. 2009;80(2):210-218.
  • 10. Alpiste Illueca FM, Buitrago Vera P, de Grado Cabanilles P, Fuenmayor Fernandez V, Gil Loscos FJ. Periodontal regeneration in clinical practice. Med Oral Patol Oral Cir Bucal. 2006;11(4):82-92.
  • 11. Gawaz M, Vogel S. Platelets in tissue repair: Control of apoptosis and interactions with regenerative cells. Blood. 2013;122(15):2550-2554.
  • 12. Ehrenfest DMD, Sammartino G, Shibli JA, Wang H, Zou D, Bernard J. Guidelines for the publication of articles related to platelet concentrates ( Platelet-Rich Plasma - PRP , or Platelet-Rich Fibrin - PRF): the international classification of the POSEIDO. POSEIDO Journal. 2013;1(1):17-27.
  • 13. Dohan DM, Choukroun J, Diss A, Dohan SL, Dohan AJJ, Mouhyi J, Gogly B. Platelet-rich fibrin (PRF): A second-generation platelet concentrate. Part I: Technological concepts and evolution. Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. 2006;101(3):e37-44.
  • 14. Dohan Ehrenfest DM, Rasmusson L, Albrektsson T. Classification of platelet concentrates: from pure platelet-rich plasma (P-PRP) to leucocyte- and platelet-rich fibrin (L-PRF). Trends Biotechnol. 2009;27(3):158-167.
  • 15. Choukroun J, Diss A, Simonpieri A, et al. Platelet- rich fibrin (PRF): A second-generation platelet concentrate. Part V: Histologic evaluations of PRF effects on bone allograft maturation in sinus lift. Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. 2006;101(3):299-303.
  • 16. Kiran NK, Mukunda K S, Tilak T RN. Platelet Concentrates: A Promising Innovation In Dentistry. J. Dent. Sci. Res. 2011;2(1):50-61.
  • 17. Casati MZ, de Vasconcelos Gurgel BC, Gonçalves PF, et al. Platelet-rich plasma does not improve bone regeneration around peri-implant bone defects-A pilot study in dogs. Int J Oral Maxillofac Surg. 2007;36(2):132-136.
  • 18. Dohan Ehrenfest DM, de Peppo GM, Doglioli P, Sammartino G. Slow release of growth factors and thrombospondin-1 in Choukroun’s platelet-rich fibrin (PRF): A gold standard to achieve for all surgical platelet concentrates technologies. Growth Factors. 2009;27(1):63-69.
  • 19. Preeja C, Arun S. Platelet-rich fibrin: Its role in periodontal regeneration. Saudi J Dent Res. 2014;5(2):117-122.
  • 20. Raja S, Byakod G, Pudakalkatti P. Growth factors in periodontal regeneration. Int J Dent Hyg. 2009;7(2):82-89.
  • 21. Gassling V, Douglas T, Warnke PH, Açil Y, Wiltfang J, Becker ST. Platelet-rich fibrin membranes as scaffolds for periosteal tissue engineering. Clin Oral Implants Res. 2010;21(5):543-549.
  • 22. Gupta V, Bains V, Singh G, Mathur A, Bains R. Regenerative potential of platelet rich fibrin in dentistry: literature review. Asian J. Oral Health Allied Sci. 2011;1(2):3-8.
  • 23. Aroca S, Keglevich T, Barbieri B, Gera I, Etienne D. Clinical Evaluation of a Modified Coronally Advanced Flap Alone or in Combination With a Platelet-Rich Fibrin Membrane for the Treatment of Adjacent Multiple Gingival Recessions: A 6- Month Study. J Periodontol. 2009;80(2):244-252.
  • 24. Kim SG, Kim WK, Park JC, Kim HJ. A comparative study of osseointegration of avana implants in a demineralized freeze-dried bone alone or with platelet-rich plasma. J Oral Maxillofac Surg. 2002;60(9):1018-1025.
  • 25. Marx RE, Carlson ER, Eichstaedt RM, Schimmele SR, Strauss JE, Georgeff KR. Platelet-rich plasma: Growth factor enhancement for bone grafts. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1998;85(6):638-646.
  • 26. Tara L Aghaloo, Peter K Moy EGF. Investigation of platelet-rich plasma in rabbit cranial defects: A pilot study. J Oral Maxillofac Surg. 2002;60(10):1176-1181.
  • 27. Dohan DM, Del Corso M, Charrier JB. Cytotoxicity analyses of Choukroun’s platelet-rich fibrin (PRF) on a wide range of human cells: The answer to a commercial controversy. Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. 2007;103(5):587-593.
  • 28. Pradeep AR, Rao NS, Agarwal E, Bajaj P, Kumari M, Naik SB. Comparative Evaluation of Autologous Platelet-Rich Fibrin and Platelet-Rich Plasma in the Treatment of 3-Wall Intrabony Defects in Chronic Periodontitis: A Randomized Controlled Clinical Trial. J Periodontol. 2012;83(12):1499-1507.
  • 29. Chang YC, Zhao JH. Effects of platelet-rich fibrin on human periodontal ligament fibroblasts and application for periodontal infrabony defects. Aust Dent J. 2011;56(4):365-371.
  • 30. Molly L, Quirynen M, Michiels K, Van Steenberghe D. Comparison between jaw bone augmentation by means of a stiff occlusive titanium membrane or an autologous hip graft: A retrospective clinical assessment. Clin Oral Implants Res. 2006;17(5):481-487.
  • 31. Ghanaati S, Booms P, Orlowska A, et al. Advanced platelet-rich fibrin: A new concept for cell- Based tissue engineering by means of inflammatory cells. J Oral Implantol. 2014;40(6):679-689.
  • 32. Miron RJ, Fujioka-Kobayashi M, Hernandez M, et al. Injectable platelet rich fibrin (i-PRF): opportunities in regenerative dentistry? Clin Oral Investig. 2017;21(8):2619-2627.
  • 33. Kobayashi E, Flückiger L, Fujioka-Kobayashi M, et al. Comparative release of growth factors from PRP, PRF, and advanced-PRF. Clin Oral Investig. 2016;20(9):2353-2360.
  • 34. Rinaldi S, Bussa M, Mascaro A. Update on the treatment of androgenetic alopecia. Eur. Rev. Med. Pharmacol. Sci. 2016;20(1):54-58.
  • 35. Fujioka-Kobayashi M, Miron RJ, Hernandez M, Kandalam U, Zhang Y, Choukroun J. Optimized Platelet-Rich Fibrin With the Low-Speed Concept: Growth Factor Release, Biocompatibility, and Cellular Response. J Periodontol. 2017;88(1):112- 121.
  • 36. Tunali M, Özdemir H, Küçükodaci Z, Akman S, Firatli E. In vivo evaluation of titanium-prepared platelet-rich fibrin (T-PRF): A new platelet concentrate. Br J Oral Maxillofac Surg. 2013;51(5):438-443.
  • 37. Takemoto S, Yamamoto T, Tsuru K, Hayakawa S, Osaka A, Takashima S. Platelet adhesion on titanium oxide gels: Effect of surface oxidation. Biomaterials. 2004;25(17):3485-3492.
  • 38. Tukaram Kshirsagar Professor J, Post Graduate Student RS, Rubine Post Graduate Student CS, Tukaram Kshirsagar J. Innovation in regeneration – Concentrated growth factor. Int J Appl Dent Sci IJADS. 2017;3(32):206-208.
  • 39. Dong-Seok S. The Use of Concentrated Growth Factors As Alternative To Bone Substitutes For Sinus Augmentation. Dental Inc. 2009:2-7.
  • 40. Miron RJ, Fujioka-Kobayashi M, Bishara M, Zhang Y, Hernandez M, Choukroun J. Platelet-Rich Fibrin and Soft Tissue Wound Healing: A Systematic Review. Tissue Eng - Part B Rev. 2017;23(1):83-99.
  • 41. A.M. Everts P, M. Hoogbergen M, A.Weber T, J.J. Devilee R, van Monftort G, H.J.T. de Hingh I. Is the Use of Autologous Platelet-Rich Plasma Gels in Gynecologic, Cardiac, and General, Reconstructive Surgery Beneficial? Curr Pharm Biotechnol. 2012;13(7):1163-1172.
  • 42. Reynolds MA, Kao RT, Camargo PM, et al. Periodontal Regeneration – Intrabony Defects: A Consensus Report From the AAP Regeneration Workshop. J Periodontol. 2015;86(2-s):S105-S107.
  • 43. Ivanovski S. Periodontal regeneration. Aust Dent J. 2009;54:S118-S128.
  • 44. Choukroun J, Diss A, Simonpieri A, Girard MO, Schoeffler C, Dohan SL, Dohan AJJ, Mouhyi J, Dohan DM. (a). Platelet-rich fibrin (PRF): A second-generation platelet concentrate. Part IV: Clinical effects on tissue healing. Oral. Surg. Oral. Med. Oral. Pathol. Oral. Radiol. Endod. 2006;101(3):1-5.
  • 45. Fontana S, Olmedo DG, Linares JA, Guglielmotti MB, Crosa ME. Effect of platelet-rich plasma on the peri-implant bone response: An experimental study. Implant Dent. 2004;13(1):73-78.
  • 46. Anitua EA. Enhancement of osseointegration by generating a dynamic implant surface. J Oral Implantol. 2006;32(2):72-76.
  • 47. Soni R, Priya A, Yadav H, Mishra N, Kumar L. Bone augmentation with sticky bone and platelet- rich fibrin by ridge-split technique and nasal floor engagement for immediate loading of dental implant after extracting impacted canine. Natl J Maxillofac Surg. 2019;10(1):98.
  • 48. Borie E, Oliví DG, Orsi IA, et al. Platelet-rich fibrin application in dentistry: A literature review. Int J Clin Exp Med. 2015;8(5):7922-7929.
  • 49. Park HC, Kim SG, Oh JS, et al. Early bone formation at a femur defect using CGF and PRF grafts in adult dogs: A comparative study. Implant Dent. 2016;25(3):387-393.
  • 50. Pirpir C, Yilmaz O, Candirli C, Balaban E. Evaluation of effectiveness of concentrated growth factor on osseointegration. Int J Implant Dent. 2017;3(1).
  • 51. Dhurat R, Sukesh M. Principles and methods of preparation of platelet-rich plasma: A review and author′s perspective. J Cutan Aesthet Surg. 2014;7(4):189.
  • 52. Dohan Ehrenfest DM, Del Corso M, Diss A, Mouhyi J, Charrier J-B. Three-Dimensional Architecture and Cell Composition of a Choukroun’s Platelet-Rich Fibrin Clot and Membrane. J Periodontol. 2010;81(4):546-555.
  • 53. Nelson R, Andy T, Ana C, Simone C. Guidelines for the use of L-PRF Flow Charts: Step by Step Approach Leucocytes and Platelet Rich Fibrin in Different Intra-oral Applications Applying the IntraSpin TM Concept. Researchgate. 2017. https://kuleuvencongres.be/ENHD2018/guideline s-for-use-of-l-prf.pdf
  • 54. Nunes CR, Roedersheimer MT, Simske SJ, Luttges MW. Effect of microgravity, temperature, and concentration on fibrin and collagen assembly. Microgravity Sci. Technol. 1995;8(2):125-130.
  • 55. Miron RJ, Chai J, Zhang P, et al. A novel method for harvesting concentrated platelet-rich fibrin (C- PRF) with a 10-fold increase in platelet and leukocyte yields. Clin Oral Investig. 2020;24(8):2819-2828.
APA ALSHUJAA B, Talmaç A, ALSAFADI A (2023). Autologous Platelet Concentrates: Their Generations, Forms, Preparation Protocols and Roles in Periodontal Regeneration. , 369 - 377. 10.5505/ejm.2023.84758
Chicago ALSHUJAA BASEM,Talmaç Ahmet Cemil,ALSAFADI ANAS Autologous Platelet Concentrates: Their Generations, Forms, Preparation Protocols and Roles in Periodontal Regeneration. (2023): 369 - 377. 10.5505/ejm.2023.84758
MLA ALSHUJAA BASEM,Talmaç Ahmet Cemil,ALSAFADI ANAS Autologous Platelet Concentrates: Their Generations, Forms, Preparation Protocols and Roles in Periodontal Regeneration. , 2023, ss.369 - 377. 10.5505/ejm.2023.84758
AMA ALSHUJAA B,Talmaç A,ALSAFADI A Autologous Platelet Concentrates: Their Generations, Forms, Preparation Protocols and Roles in Periodontal Regeneration. . 2023; 369 - 377. 10.5505/ejm.2023.84758
Vancouver ALSHUJAA B,Talmaç A,ALSAFADI A Autologous Platelet Concentrates: Their Generations, Forms, Preparation Protocols and Roles in Periodontal Regeneration. . 2023; 369 - 377. 10.5505/ejm.2023.84758
IEEE ALSHUJAA B,Talmaç A,ALSAFADI A "Autologous Platelet Concentrates: Their Generations, Forms, Preparation Protocols and Roles in Periodontal Regeneration." , ss.369 - 377, 2023. 10.5505/ejm.2023.84758
ISNAD ALSHUJAA, BASEM vd. "Autologous Platelet Concentrates: Their Generations, Forms, Preparation Protocols and Roles in Periodontal Regeneration". (2023), 369-377. https://doi.org/10.5505/ejm.2023.84758
APA ALSHUJAA B, Talmaç A, ALSAFADI A (2023). Autologous Platelet Concentrates: Their Generations, Forms, Preparation Protocols and Roles in Periodontal Regeneration. Eastern Journal of Medicine, 28(2), 369 - 377. 10.5505/ejm.2023.84758
Chicago ALSHUJAA BASEM,Talmaç Ahmet Cemil,ALSAFADI ANAS Autologous Platelet Concentrates: Their Generations, Forms, Preparation Protocols and Roles in Periodontal Regeneration. Eastern Journal of Medicine 28, no.2 (2023): 369 - 377. 10.5505/ejm.2023.84758
MLA ALSHUJAA BASEM,Talmaç Ahmet Cemil,ALSAFADI ANAS Autologous Platelet Concentrates: Their Generations, Forms, Preparation Protocols and Roles in Periodontal Regeneration. Eastern Journal of Medicine, vol.28, no.2, 2023, ss.369 - 377. 10.5505/ejm.2023.84758
AMA ALSHUJAA B,Talmaç A,ALSAFADI A Autologous Platelet Concentrates: Their Generations, Forms, Preparation Protocols and Roles in Periodontal Regeneration. Eastern Journal of Medicine. 2023; 28(2): 369 - 377. 10.5505/ejm.2023.84758
Vancouver ALSHUJAA B,Talmaç A,ALSAFADI A Autologous Platelet Concentrates: Their Generations, Forms, Preparation Protocols and Roles in Periodontal Regeneration. Eastern Journal of Medicine. 2023; 28(2): 369 - 377. 10.5505/ejm.2023.84758
IEEE ALSHUJAA B,Talmaç A,ALSAFADI A "Autologous Platelet Concentrates: Their Generations, Forms, Preparation Protocols and Roles in Periodontal Regeneration." Eastern Journal of Medicine, 28, ss.369 - 377, 2023. 10.5505/ejm.2023.84758
ISNAD ALSHUJAA, BASEM vd. "Autologous Platelet Concentrates: Their Generations, Forms, Preparation Protocols and Roles in Periodontal Regeneration". Eastern Journal of Medicine 28/2 (2023), 369-377. https://doi.org/10.5505/ejm.2023.84758