Safety and Efficacy of Holmium Laser Enucleation of the Prostate (HoLEP) in Patients Requiring Anticoagulants/Antiplatelets: A Retrospective Study
Yıl: 2023 Cilt: 10 Sayı: 2 Sayfa Aralığı: 101 - 106 Metin Dili: İngilizce DOI: 10.4274/jus.galenos.2022.2022.0062 İndeks Tarihi: 06-06-2023
Safety and Efficacy of Holmium Laser Enucleation of the Prostate (HoLEP) in Patients Requiring Anticoagulants/Antiplatelets: A Retrospective Study
Öz: Objective: We evaluated Holmium Laser Enucleation of the Prostate (HoLEP) surgery performed in patients with benign prostatic obstruction (BPO) requiring anticoagulant/antiplatelet (AC/AP) therapy in terms of safety and efficacy. Materials and Methods: The retrospective data of 250 patients who underwent HoLEP between January 2020-May 2022 were included in the study. AC/AP treatment status’ of patients was recorded. The patients were divided into two groups as those requiring AC/AP (group 1, n=129) and those not using (group 2, n=121). Basic characteristics, preoperative and postoperative IPSS scores, Qmax and continence status’ at 1st and 6th month follow-up were recorded. Intra- and postoperative complications were recorded according to Clavien-Dindo classification. Results: No significant difference was observed between the groups in terms of preoeprative characteristics including prostate-specific antigen, hemoglobin (Hb), prostate volume, IPSS, Quality of Life score, Qmax, Qave and postvoiding residuel volume (p>0.05). There was no significant difference between the two groups in terms of postoperative functional parameters and urinary continence (p>0.05) and in Hb drop (0.13±0.1 g/ dL vs. 0.08±0.15 g/dL, respectively; p=0.21). The blood transfusion rate was 2.3% in group 1 and 0.8% in group 2, and there was no significant difference between the groups (p=0.62). Additionally, there was no significant difference between the groups regarding complications. Conclusion: HoLEP is a safe and effective, minimally invasive surgical method that improves functional parameters in BPO patients requiring AC/AP.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
- 1. Vincent MW, Gilling PJ. HoLEP has come of age. World J Urol 2015;33:487- 493.
- 2. Larner TR, Agarwal D, Costello AJ. Day-case holmium laser enucleation of the prostate for gland volumes of < 60 mL: early experience. BJU Int 2003;91:61-64.
- 3. Berry SJ, Coffey DS, Walsh PC, Ewing LL. The development of human benign prostatic hyperplasia with age. J Urol 1984;132:474-479.
- 4. Egan KB. The Epidemiology of Benign Prostatic Hyperplasia Associated with Lower Urinary Tract Symptoms: Prevalence and Incident Rates. Urol Clin North Am 2016;43:289-297.
- 5. Go AS, Hylek EM, Phillips KA, Chang Y, Henault LE, Selby JV, Singer DE. Prevalence of diagnosed atrial fibrillation in adults: national implications for rhythm management and stroke prevention: the AnTicoagulation and Risk Factors in Atrial Fibrillation (ATRIA) Study. JAMA 2001;285:2370-2375.
- 6. Gacci M, Corona G, Sebastianelli A, Serni S, De Nunzio C, Maggi M, Vignozzi L, Novara G, McVary KT, Kaplan SA, Gravas S, Chapple C. Male Lower Urinary Tract Symptoms and Cardiovascular Events: A Systematic Review and Meta- analysis. Eur Urol 2016;70:788-796.
- 7. Jin S, Liu Z, Liu Y, Wu J, Yu Q. Analysis of Risk Factors and Nursing Strategies for Postoperative Hemorrhage of Benign Prostatic Hyperplasia. Evid Based Complement Alternat Med 2022;2022:4205015.
- 8. Martin AD, Nunez RN, Humphreys MR. Bleeding after holmium laser enucleation of the prostate: lessons learned the hard way. BJU Int 2011;107:433-437.
- 9. Bozzini G, Maltagliati M, Besana U, Berti L, Calori A, Sighinolfi MC, Micali S, Roche JB, Gozen A, Mueller A, Pushkar D, Liatsikos E, Boldini M, Buizza C, Rocco B. Holmium laser enucleation of the prostate with Virtual Basket mode: faster and better control on bleeding. BMC Urol 2021;21:28.
- 10. Abrams P, Cardozo L, Fall M, Griffiths D, Rosier P, Ulmsten U, Van Kerrebroeck P, Victor A, Wein A. The standardisation of terminology in lower urinary tract function: report from the standardisation sub-committee of the International Continence Society. Urology 2003;61:37-49.
- 11. Mamoulakis C, Efthimiou I, Kazoulis S, Christoulakis I, Sofras F. The modified Clavien classification system: a standardized platform for reporting complications in transurethral resection of the prostate. World J Urol 2011;29:205-210.
- 12. Tunc L, Yalcin S, Kaya E, Gazel E, Yılmaz S, Aybal HC, Yılmaz M, Tokas T. The "Omega Sign": a novel HoLEP technique that improves continence outcomes after enucleation. World J Urol 2021;39:135-141.
- 13. Nair SM, Pimentel MA, Gilling PJ. A Review of Laser Treatment for Symptomatic BPH (Benign Prostatic Hyperplasia). Curr Urol Rep 2016;17:45.
- 14. Rieken M, Ebinger Mundorff N, Bonkat G, Wyler S, Bachmann A. Complications of laser prostatectomy: a review of recent data. World J Urol 2010;28:53-62.
- 15. Jhanwar A, Sinha RJ, Bansal A, Prakash G, Singh K, Singh V. Outcomes of transurethral resection and holmium laser enucleation in more than 60 g of prostate: A prospective randomized study. Urol Ann 2017;9:45-50.
- 16. Yin L, Teng J, Huang CJ, Zhang X, Xu D. Holmium laser enucleation of the prostate versus transurethral resection of the prostate: a systematic review and meta-analysis of randomized controlled trials. J Endourol 2013;27:604- 611.
- 17. Selim A, Nottingham CU, York NE, Dauw CA, Borofsky MS, Boris RS, Lingeman JE. Holmium laser enucleation of the prostate in Jehovah's Witness patients. Int Urol Nephrol 2020;52:455-460.
- 18. Elmansy HM, Kotb A, Elhilali MM. Holmium laser enucleation of the prostate: long-term durability of clinical outcomes and complication rates during 10 years of followup. J Urol 2011;186:1972-1976.
- 19. Elzayat EA, Habib EI, Elhilali MM. Holmium laser enucleation of the prostate: a size-independent new "gold standard". Urology 2005;66:108-113.
- 20. Placer J, Gelabert-Mas A, Vallmanya F, Manresa JM, Menéndez V, Cortadellas R, Arango O. Holmium laser enucleation of prostate: outcome and complications of self-taught learning curve. Urology 2009;73:1042- 1048.
- 21. Shah HN, Mahajan AP, Hegde SS, Bansal MB. Peri-operative complications of holmium laser enucleation of the prostate: experience in the first 280 patients, and a review of literature. BJU Int 2007;100:94-101.
- 22. El Tayeb MM, Jacob JM, Bhojani N, Bammerlin E, Lingeman JE. Holmium Laser Enucleation of the Prostate in Patients Requiring Anticoagulation. J Endourol 2016;30:805-809.
- 23. Hendrickson JE, Hillyer CD. Noninfectious serious hazards of transfusion. Anesth Analg 2009;108:759-769.
- 24. Osterman JL, Arora S. Blood Product Transfusions and Reactions. Emerg Med Clin North Am 2017;31:1159-1170.
- 25. Elzayat E, Habib E, Elhilali M. Holmium laser enucleation of the prostate in patients on anticoagulant therapy or with bleeding disorders. J Urol 2006;175:1428-1432.
- 26. Tyson MD, Lerner LB. Safety of holmium laser enucleation of the prostate in anticoagulated patients. J Endourol 2009;23:1343-1346.
- 27. Zheng X, Peng L, Cao D, Han X, Xu H, Yang L, Ai J, Wei Q. Holmium laser enucleation of the prostate in benign prostate hyperplasia patients with or without oral antithrombotic drugs: a meta-analysis. Int Urol Nephrol 2019;51:2127-2136.
| APA | YILMAZ M, Acikgoz O, Aybal H, YILDIZ K, GAZEL E, Tunc L (2023). Safety and Efficacy of Holmium Laser Enucleation of the Prostate (HoLEP) in Patients Requiring Anticoagulants/Antiplatelets: A Retrospective Study. , 101 - 106. 10.4274/jus.galenos.2022.2022.0062 |
| Chicago | YILMAZ MEHMET,Acikgoz Onur,Aybal Halil Cagri,YILDIZ KENAN YİĞİT,GAZEL EYMEN,Tunc Lutfi Safety and Efficacy of Holmium Laser Enucleation of the Prostate (HoLEP) in Patients Requiring Anticoagulants/Antiplatelets: A Retrospective Study. (2023): 101 - 106. 10.4274/jus.galenos.2022.2022.0062 |
| MLA | YILMAZ MEHMET,Acikgoz Onur,Aybal Halil Cagri,YILDIZ KENAN YİĞİT,GAZEL EYMEN,Tunc Lutfi Safety and Efficacy of Holmium Laser Enucleation of the Prostate (HoLEP) in Patients Requiring Anticoagulants/Antiplatelets: A Retrospective Study. , 2023, ss.101 - 106. 10.4274/jus.galenos.2022.2022.0062 |
| AMA | YILMAZ M,Acikgoz O,Aybal H,YILDIZ K,GAZEL E,Tunc L Safety and Efficacy of Holmium Laser Enucleation of the Prostate (HoLEP) in Patients Requiring Anticoagulants/Antiplatelets: A Retrospective Study. . 2023; 101 - 106. 10.4274/jus.galenos.2022.2022.0062 |
| Vancouver | YILMAZ M,Acikgoz O,Aybal H,YILDIZ K,GAZEL E,Tunc L Safety and Efficacy of Holmium Laser Enucleation of the Prostate (HoLEP) in Patients Requiring Anticoagulants/Antiplatelets: A Retrospective Study. . 2023; 101 - 106. 10.4274/jus.galenos.2022.2022.0062 |
| IEEE | YILMAZ M,Acikgoz O,Aybal H,YILDIZ K,GAZEL E,Tunc L "Safety and Efficacy of Holmium Laser Enucleation of the Prostate (HoLEP) in Patients Requiring Anticoagulants/Antiplatelets: A Retrospective Study." , ss.101 - 106, 2023. 10.4274/jus.galenos.2022.2022.0062 |
| ISNAD | YILMAZ, MEHMET vd. "Safety and Efficacy of Holmium Laser Enucleation of the Prostate (HoLEP) in Patients Requiring Anticoagulants/Antiplatelets: A Retrospective Study". (2023), 101-106. https://doi.org/10.4274/jus.galenos.2022.2022.0062 |
| APA | YILMAZ M, Acikgoz O, Aybal H, YILDIZ K, GAZEL E, Tunc L (2023). Safety and Efficacy of Holmium Laser Enucleation of the Prostate (HoLEP) in Patients Requiring Anticoagulants/Antiplatelets: A Retrospective Study. Journal of Urological Surgery, 10(2), 101 - 106. 10.4274/jus.galenos.2022.2022.0062 |
| Chicago | YILMAZ MEHMET,Acikgoz Onur,Aybal Halil Cagri,YILDIZ KENAN YİĞİT,GAZEL EYMEN,Tunc Lutfi Safety and Efficacy of Holmium Laser Enucleation of the Prostate (HoLEP) in Patients Requiring Anticoagulants/Antiplatelets: A Retrospective Study. Journal of Urological Surgery 10, no.2 (2023): 101 - 106. 10.4274/jus.galenos.2022.2022.0062 |
| MLA | YILMAZ MEHMET,Acikgoz Onur,Aybal Halil Cagri,YILDIZ KENAN YİĞİT,GAZEL EYMEN,Tunc Lutfi Safety and Efficacy of Holmium Laser Enucleation of the Prostate (HoLEP) in Patients Requiring Anticoagulants/Antiplatelets: A Retrospective Study. Journal of Urological Surgery, vol.10, no.2, 2023, ss.101 - 106. 10.4274/jus.galenos.2022.2022.0062 |
| AMA | YILMAZ M,Acikgoz O,Aybal H,YILDIZ K,GAZEL E,Tunc L Safety and Efficacy of Holmium Laser Enucleation of the Prostate (HoLEP) in Patients Requiring Anticoagulants/Antiplatelets: A Retrospective Study. Journal of Urological Surgery. 2023; 10(2): 101 - 106. 10.4274/jus.galenos.2022.2022.0062 |
| Vancouver | YILMAZ M,Acikgoz O,Aybal H,YILDIZ K,GAZEL E,Tunc L Safety and Efficacy of Holmium Laser Enucleation of the Prostate (HoLEP) in Patients Requiring Anticoagulants/Antiplatelets: A Retrospective Study. Journal of Urological Surgery. 2023; 10(2): 101 - 106. 10.4274/jus.galenos.2022.2022.0062 |
| IEEE | YILMAZ M,Acikgoz O,Aybal H,YILDIZ K,GAZEL E,Tunc L "Safety and Efficacy of Holmium Laser Enucleation of the Prostate (HoLEP) in Patients Requiring Anticoagulants/Antiplatelets: A Retrospective Study." Journal of Urological Surgery, 10, ss.101 - 106, 2023. 10.4274/jus.galenos.2022.2022.0062 |
| ISNAD | YILMAZ, MEHMET vd. "Safety and Efficacy of Holmium Laser Enucleation of the Prostate (HoLEP) in Patients Requiring Anticoagulants/Antiplatelets: A Retrospective Study". Journal of Urological Surgery 10/2 (2023), 101-106. https://doi.org/10.4274/jus.galenos.2022.2022.0062 |
