TY  - JOUR
TI  - Protective Effects of Ellagic Acid on Testicular Ischemia-Reperfusion Injury in Rats
AB  - Objective: This study aimed to investigate the protective effects of ellagic acid on testicular ischemia/reperfusion injury in rats. Materials and Methods: Twenty-one Sprague-Dawley rats were randomly divided into three groups: sham, ischemia/reperfusion (I/R), I/R + ellagic acid (EA). All animals underwent left scrotal exploration. In all groups except the sham group, the left testes were rotated 720 degrees clockwise for 3 h and 3 h reperfusion. 10 mg/kg ellagic acid was administered intraperitoneally to the I/R+E group before reperfusion. Then, the left orchiectomy was performed. The testes underwent biochemical and histological examination. Results: There was a significant difference between the sham and the I/R, I/R+EA groups according to the Cosentino system (p<0.001, p=0.036), and there was no difference between the I/R and IR+EA groups (p=0.319). A significant difference was found between sham and I/R groups according to Johnsen spermatogenesis score (p<0.001), but there was no significant difference between sham and I/R+EA groups (p=0.063). Superoxide dismutase, catalase, malondialdehyde, total oxidant status values were statistically different between I/R and I/R+EA groups (p=0.001, 0.002, 0.002, 0.001 respectively). Conclusion: Ellagic acid has a protective effect against testicular ischemia/reperfusion injury in rats.
AU  - Ergün, Raziye
AU  - YİĞİT, Ertuğrul
AU  - KARTAL, seyfi
AU  - Ramazanoglu, Mehmet Akif
AU  - Sekerci, Cagri Akin
AU  - Aydin, Hasan Riza
AU  - LİVAOĞLU, Ayten
AU  - Toprak, Tuncay
AU  - GüÜÇTAŞ, Ahmet Özgür
AU  - KOCAGÜL, Hüseyin
AU  - DEĞER, Orhan
DO  - 10.4274/jus.galenos.2022.2022.0049
PY  - 2023
JO  - Journal of Urological Surgery
VL  - 10
IS  - 2
SN  - 2148-9580
SP  - 160
EP  - 166
DB  - TRDizin
UR  - http://search/yayin/detay/1179721
ER  -