The Effects of Curcumin on Mechanical Functions and Cardiac Contractility in Isolated Rat Hearts
Yıl: 2023 Cilt: 51 Sayı: 4 Sayfa Aralığı: 235 - 240 Metin Dili: İngilizce DOI: 10.5543/tkda.2022.69765 İndeks Tarihi: 07-06-2023
The Effects of Curcumin on Mechanical Functions and Cardiac Contractility in Isolated Rat Hearts
Öz: Objective: Curcumin is a bioactive compound that has well-known pharmacological activities. Numerous studies have shown that curcumin provides potential cardiovascular benefits through a variety of mechanisms.The present study aims to discuss different concentrations of curcum- in’s impact on mechanical functions and cardiac contractility in isolated perfused rat hearts. Methods: The hearts were isolated under sodium thiopental (50 mg/kg) anesthesia and per- fused with a modified Krebs-Henseleit solution (mK-Hs). After stabilization, curcumin was applied in concentrations of 0.1, 1, and 10 μM. In isolated rat hearts, indexes of + dP / dt max, LVDP, MAP, and LVEDP were evaluated for cardiac contractility and ventricular function. Results: All curcumin concentrations reduced +dP/dtmax and LVDP. Ten μM curcumin also sig- nificantly decreased heart rate. Curcumin (1 and 10 μM) increased LVEDP and reduced MAP amplitude with a concomitant increase in MAP duration. Curcumin at all concentrations did not affect dMAPdtmax and dMAPdtmin. Conclusion: Our results might suggest that curcumin at higher concentrations (≥ 1 μM) increases LVEDP with a negative chronotropic effect and decreases MAP amplitude with an increase in MAP duration. There is sufficient evidence from this study that Curcumin possesses an adverse inotropic action. Different disease models should support the pathophysiological role of Curcumin on cardiac contraction.
Anahtar Kelime: Kurkuminin İzole Sıçan Kalbinde Mekanik Fonksiyonlar ve Kardiyak Kontraktilite Üzerine Etkisi
Öz: Amaç: Kurkumin, iyi bilinen farmakolojik aktiviteleri olan biyoaktif bir bileşiktir. Kurkuminin çeşitli mekanizmalar yoluyla potansiyel kardiyovasküler faydalar sağladığı çok sayıda çalışma ile gösterilmiştir. Bu çalışma, izole perfüze edilmiş sıçan kalplerinde farklı kurkumin kon- santrasyonlarının mekanik fonksiyonlar ve kardiyak kontraktilite üzerindeki etkisini tartışmayı amaçlamaktadır. Yöntem: Kalpler, sodyum tiyopental (50 mg/kg) anestezisi altında izole edildi ve modifiye edilmiş bir Krebs-Henseleit solüsyonu (mK-Hs) ile perfüze edildi. Stabilizasyondan sonra 0,1, 1 ve 10 μM konsantrasyonlarda kurkumin uygulandı. +dP/dt max, LVDP, MAP ve LVEDP indeksleri izole sıçan kalplerinde kardiyak kontraktilite ve ventriküler fonksiyon açısından değerlendirildi. Bulgular: Tüm kurkumin konsantrasyonları +dP/dtmax ve LVDP'yi azalttı. On μM kurkumin de kalp atış hızını önemli ölçüde azalttı. Kurkumin (1 ve 10 μM), MAP süresinde bir artışla birlikte LVEDP'yi arttırdı ve MAP amplitüdünü azalttı. Tüm konsantrasyonlardaki kurkumin, dMAPdt- max ve dMAPdtmin'i etkilemedi. Sonuç: Sonuçlarımız, kurkuminin daha yüksek konsantrasyonlarda (≥ 1 μM) negatif kronotro- pik etki ile LVEDP'yi arttırdığını ve MAP süresindeki artışla MAP amplitüdünü azalttığını düşün- dürebilir. Bu çalışmada kurkuminin negatif bir inotropik etkiye sahip olduğuna dair yeterli kanıt bulunmaktadır. Kurkuminin kalp kasılması üzerindeki patofizyolojik rolü, farklı hastalık modelleri ile desteklenmelidir.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | Kutlay Ö, KAYGISIZ B, Keskin-Aktan A (2023). The Effects of Curcumin on Mechanical Functions and Cardiac Contractility in Isolated Rat Hearts. , 235 - 240. 10.5543/tkda.2022.69765 |
| Chicago | Kutlay Özden,KAYGISIZ Bilgin,Keskin-Aktan Arzu The Effects of Curcumin on Mechanical Functions and Cardiac Contractility in Isolated Rat Hearts. (2023): 235 - 240. 10.5543/tkda.2022.69765 |
| MLA | Kutlay Özden,KAYGISIZ Bilgin,Keskin-Aktan Arzu The Effects of Curcumin on Mechanical Functions and Cardiac Contractility in Isolated Rat Hearts. , 2023, ss.235 - 240. 10.5543/tkda.2022.69765 |
| AMA | Kutlay Ö,KAYGISIZ B,Keskin-Aktan A The Effects of Curcumin on Mechanical Functions and Cardiac Contractility in Isolated Rat Hearts. . 2023; 235 - 240. 10.5543/tkda.2022.69765 |
| Vancouver | Kutlay Ö,KAYGISIZ B,Keskin-Aktan A The Effects of Curcumin on Mechanical Functions and Cardiac Contractility in Isolated Rat Hearts. . 2023; 235 - 240. 10.5543/tkda.2022.69765 |
| IEEE | Kutlay Ö,KAYGISIZ B,Keskin-Aktan A "The Effects of Curcumin on Mechanical Functions and Cardiac Contractility in Isolated Rat Hearts." , ss.235 - 240, 2023. 10.5543/tkda.2022.69765 |
| ISNAD | Kutlay, Özden vd. "The Effects of Curcumin on Mechanical Functions and Cardiac Contractility in Isolated Rat Hearts". (2023), 235-240. https://doi.org/10.5543/tkda.2022.69765 |
| APA | Kutlay Ö, KAYGISIZ B, Keskin-Aktan A (2023). The Effects of Curcumin on Mechanical Functions and Cardiac Contractility in Isolated Rat Hearts. Türk Kardiyoloji Derneği Arşivi, 51(4), 235 - 240. 10.5543/tkda.2022.69765 |
| Chicago | Kutlay Özden,KAYGISIZ Bilgin,Keskin-Aktan Arzu The Effects of Curcumin on Mechanical Functions and Cardiac Contractility in Isolated Rat Hearts. Türk Kardiyoloji Derneği Arşivi 51, no.4 (2023): 235 - 240. 10.5543/tkda.2022.69765 |
| MLA | Kutlay Özden,KAYGISIZ Bilgin,Keskin-Aktan Arzu The Effects of Curcumin on Mechanical Functions and Cardiac Contractility in Isolated Rat Hearts. Türk Kardiyoloji Derneği Arşivi, vol.51, no.4, 2023, ss.235 - 240. 10.5543/tkda.2022.69765 |
| AMA | Kutlay Ö,KAYGISIZ B,Keskin-Aktan A The Effects of Curcumin on Mechanical Functions and Cardiac Contractility in Isolated Rat Hearts. Türk Kardiyoloji Derneği Arşivi. 2023; 51(4): 235 - 240. 10.5543/tkda.2022.69765 |
| Vancouver | Kutlay Ö,KAYGISIZ B,Keskin-Aktan A The Effects of Curcumin on Mechanical Functions and Cardiac Contractility in Isolated Rat Hearts. Türk Kardiyoloji Derneği Arşivi. 2023; 51(4): 235 - 240. 10.5543/tkda.2022.69765 |
| IEEE | Kutlay Ö,KAYGISIZ B,Keskin-Aktan A "The Effects of Curcumin on Mechanical Functions and Cardiac Contractility in Isolated Rat Hearts." Türk Kardiyoloji Derneği Arşivi, 51, ss.235 - 240, 2023. 10.5543/tkda.2022.69765 |
| ISNAD | Kutlay, Özden vd. "The Effects of Curcumin on Mechanical Functions and Cardiac Contractility in Isolated Rat Hearts". Türk Kardiyoloji Derneği Arşivi 51/4 (2023), 235-240. https://doi.org/10.5543/tkda.2022.69765 |
