Effect of Fetuin-A and oxidative stress on the occurrence of unexplained infertility
Yıl: 2023 Cilt: 20 Sayı: 2 Sayfa Aralığı: 113 - 119 Metin Dili: İngilizce DOI: 10.4274/tjod.galenos.2023.87936 İndeks Tarihi: 07-06-2023
Effect of Fetuin-A and oxidative stress on the occurrence of unexplained infertility
Öz: Objective: Unexplained infertility refers to a diagnosis in which all standard examinations are usually normal and is statistically seen in approximately 30-40% of infertile couples and endometriosis encountered in 25-50% of patients with unexplained infertility. Unexplained infertility is thought to be closely associated with endometriosis and serum and peritoneal fluid levels of Fetuin-A is increased in patients with endometriosis. Fetuin-A is proposed as a diagnostic marker for endometriosis and has anti-inflammatory effects on several diseases. Oxidative stress also is central to the etiopathogenesis of infertility in women. The aim of this study was to evaluate serum Fetuin-A and oxidative stress parameter concentrations impact on unexplained infertility. Materials and Methods: In the study, serum Fetuin-A, IL-1β, CA I, TAS, TOS levels, and PON and ARE enzyme activities were measured using the Enzyme-Linked ImmunoSorbent Assay in the sera of diagnosed unexplained infertility females (n=44) and controls (n=41). Results: There was no statistically significant difference between unexplained infertile patients and control groups in terms of serum IL-1β, CA I, OSI, and PON levels (p>0.05). Serum Fetuin-A and ARE levels were significantly higher in unexplained infertility compared with the control, whereas serum TAS and TOS levels were lower (p<0.05, p<0.01, p<0.05, p<0.05, respectively). Conclusion: It is thought that increased Fetuin-A levels may be a response to the inflammatory process and increased ARE activity may be a sign of the impaired oxidant-antioxidant balance in unexplained infertility. This may contribute to the pathogenesis of infertility, and the data obtained will make a significant contribution to new works to be done in this sense.
Anahtar Kelime: Açıklanamayan infertilite oluşumunda Fetuin-A ve oksidatif stresin etkisi
Öz: Amaç: Açıklanamayan infertilite, tüm standart muayenelerin genellikle normal olduğu ve istatistiksel olarak kısır çiftlerin yaklaşık %30-40’ında görülen bir tanıyı ifade eder. Açıklanamayan infertilite hastalarının %25-50’sinde endometriozise rastlanmaktadır. Açıklanamayan infertilitenin endometriozis ile yakından ilişkili olduğu düşünülmektedir. Endometriozisli hastalarda serum ve peritoneal sıvıda Fetuin-A düzeyleri artmaktadır. Fetuin-A, endometriozis için tanısal bir belirteç olarak önerilmiştir ve çeşitli hastalıklar üzerinde anti-enflamatuvar etkilere sahip olduğu bilinmektedir. Oksidatif stres de kadınlarda infertilite etiyopatogenezinde önemli bir rol oynamaktadır. Bu çalışmanın amacı, serum Fetuin-A ve oksidatif stres parametreleri konsantrasyonlarının açıklanamayan infertilite üzerindeki etkisini değerlendirmektir. Gereç ve Yöntemler: Bu çalışmada, açıklanamayan infertilite tanısı konmuş kadınlar (n=44) ve kontrollerin (n=41) serumlarında Fetuin-A, IL-1β, CA I, TAS, TOS seviyeleri ve PON ile ARE enzim aktiviteleri Enzyme-Linked ImmunoSorbent Assay kullanılarak ölçüldü. Bulgular: Açıklanamayan infertil hasta ve kontrol grubu arasında serum IL-1β, CA I, OSI ve PON düzeyleri açısından istatistiksel olarak anlamlı fark yoktu (p>0,05). Açıklanamayan infertilitede kontrole göre serum Fetuin-A ve ARE düzeyleri anlamlı olarak yüksek, serum TAS ve TOS düzeyleri ise daha düşüktü (sırasıyla p<0,05, p<0,01, p<0,05, p<0,05). Sonuç: Açıklanamayan infertilitede artmış Fetuin-A düzeylerinin inflamatuvar sürece bir yanıt olabileceği ve artmış ARE aktivitesinin bozulmuş oksidanantioksidan dengenin bir işareti olabileceği düşünülmektedir. Elde edilen bu veriler açıklanamayan infertilitenin patogenezine katkı sağlayacak ve bu anlamda yapılacak yeni çalışmalara ışık tutacaktır.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
- 1. Zegers-Hochschild F, Adamson GD, Dyer S, Racowsky C, de Mouzon J, Sokol R, et al. The International Glossary on Infertility and Fertility Care, 2017. Hum Reprod 2017;32:1786-801.
- 2. Broi MGD, Ferriani RA, Navarro PA. Ethiopathogenic mechanisms of endometriosis-related infertility. JBRA Assist Reprod 2019;23:273-80.
- 3. Lang GA, Yeaman GR. Autoantibodies in endometriosis sera recognize a Thomsen-Friedenreich-like carbohydrate antigen. J Autoimmun 2001;16:151-61.
- 4. Jirak P, Stechemesser L, Moré E, Franzen M, Topf A, Mirna M, et al. Clinical implications of fetuin-A. Adv Clin Chem 2019;89:79-130.
- 5. Bedaiwy MA, Falcone T, Sharma RK, Goldberg JM, Attaran M, Nelson DR, et al. Prediction of endometriosis with serum and peritoneal fluid markers: a prospective controlled trial. Hum Reprod 2002;17:426-31.
- 6. Luborsky J. Ovarian autoimmune disease and ovarian autoantibodies. J Womens Health Gend Based Med 2002;115:85-99.
- 7. D’Cruz OJ, Wild RA, Haas GG Jr, Reichlin M. Antibodies to carbonic anhydrase in endometriosis: prevalence, specificity, and relationship to clinical and laboratory parameters. Fertil Steril 1996;66:547-56.
- 8. Young IS, Woodside JV. Antioxidants in health and disease. J Clin Pathol 2001;54:176-86.
- 9. Cherubini A, Ruggiero C, Polidori MC, Mecocci P. Potential markers of oxidative stress in stroke. Free Radic Biol Med 2005;39:841-52.
- 10. Ghiselli A, Serafini M, Natella F, Scaccini C. Total antioxidant capacity as a tool to assess redox status: critical view and experimental data. Free Radic Biol Med 2000;29:1106-14.
- 11. Mohamadin AM, Habib FA, Elahi TF. Serum paraoxonase 1 activity and oxidant/antioxidant status in Saudi women with polycystic ovary syndrome. Pathophysiology. 2010;17:189-96.
- 12. Fenkci IV, Serteser M, Fenkci S, Kose S. Paraoxonase levels in women with polycystic ovary syndrome. J Reprod Med 2007;52:879-8.
- 13. Gan KN, Smolen A, Eckerson HW, La Du BN. Purification of human serum paraoxonase/arylesterase. Evidence for one esterase catalyzing both activities. Drug Metab Dispos 1991;19:100-6.
- 14. Naderi M, Hashemi M, Komijani-Bozchaloei F, Moazeni-Roodi A, Momenimoghaddam M. Serum paraoxonase and arylesterase activities in patients with pulmonary tuberculosis. Pathophysiology 2011;18:117- 20.
- 15. Smith S, Pfeifer SM, Collins JA. Diagnosis and management of female infertility. JAMA 2003;290:1767-70.
- 16. Liu S, Hu W, He Y, Li L, Liu H, Gao L, et al. Serum Fetuin-A levels are increased and associated with insulin resistance in women with polycystic ovary syndrome. BMC Endocr Disord 2020;20:67.
- 17. Sak S, Uyanikoglu H, Incebiyik A, Incebiyik H, Hilali NG, Sabuncu T, et al. Associations of serum fetuin-A and oxidative stress parameters with polycystic ovary syndrome. Clin Exp Reprod Med 2018;45:116-21.
- 18. Bódis J, Peti AM, Sulyok E, Kovács GL, Várnagy A. Serum and follicular fluid fetuin-A in women undergoing in vitro fertilization. Clin Chem Lab Med 2014;52:1313-8.
- 19. Ozgu-Erdinc AS, Oskovi-Kaplan ZA, Engin-Ustun Y, Kiyak Caglayan E, Yilmaz S, Yilmaz N, et al. Recurrent implantation failure is associated with increased levels of fetuin-A/alpha2-Heremans-Schmidglycoprotein. Eur J Obstet Gynecol Reprod Biol 2020;248:1-4.
- 20. Gurbuz T, Alanya Tosun S, Cebi A, Gokmen O, Usta M. Investigating Fetuin-A and Paraoxonase-1 Activity as Markers in Polycystic Ovary Syndrome Based on Body Mass Index: A Prospective Case-Control Study. Cureus 2021;13:e18553.
- 21. Xie J, Yan L, Cheng Z, Qiang L, Yan J, Liu Y, et al. Potential effect of inflammation on the failure risk of in vitro fertilization and embryo transfer among infertile women. Hum Fertil (Camb) 2020;23:214-22.
- 22. Sequeira K, Espejel-Núñez A, Vega-Hernández E, Molina-Hernández A, Grether-González P. An increase in IL-1β concentrations in embryo culture-conditioned media obtained by in vitro fertilization on day 3 is related to successful implantation. J Assist Reprod Genet 2015;32:1623-7.
- 23. Karahan SC, Guven S, Mentese A, Bacak A, Kopuz M, Ozeren M. Serum anti-carbonic anhydrase I and II antibodies and idiopathic recurrent pregnancy loss. Reprod Biomed Online 2009;19:859-63.
- 24. Menteşe A, Güven S, Sumer A, Turan I, Demir S, Karahan S, et al. Serum anti-carbonic anhydrase I and II antibodies and polycystic ovary syndrome. Turkish Journal of Biochemistry 2013;38:43-8.
- 25. Agarwal A, Krajcir N, Chowdary H, Gupta J. Female Infertility and Assisted Reproduction: Impact of Oxidative Stress. Current Women`s Health Reviews 2008;4:9-15.
- 26. Isbilen E, Kulaksizoglu S, Kirmizioglu M, Karuserci Komurcu O, Tabur S. Role of prolidase activity and oxidative stress biomarkers in unexplained infertility. Int J Gynaecol Obstet 2022;156:430-5.
- 27. Şentürk R, Tola EN, Bozkurt M, Doğuç DK. The role of oxidant status on the etiopathogenesis of unexplained infertility and intracytoplasmic sperm injection - embryo transfer success: a case-control study. J Obstet Gynaecol 2022;42:1312-8.
- 28. Carlioglu A, Kaygusuz I, Karakurt F, Gumus II, Uysal A, Kasapoglu B, et al. The platelet activating factor acetyl hydrolase, oxidized lowdensity lipoprotein, paraoxonase 1 and arylesterase levels in treated and untreated patients with polycystic ovary syndrome. Arch Gynecol Obstet 2014;290:929-35.
- 29. Jackson LW, Schisterman EF, Dey-Rao R, Browne R, Armstrong D. Oxidative stress and endometriosis. Hum Reprod 2005;20:2014-20.
- 30. Verit FF, Erel O, Celik N. Serum paraoxonase-1 activity in women with endometriosis and its relationship with the stage of the disease. Hum Reprod 2008;23:100-4.
- 31. San Millán JL, Alvarez-Blasco F, Luque-Ramírez M, Botella-Carretero JI, Escobar-Morreale HF. The PON1-108C/T polymorphism, and not the polycystic ovary syndrome, is an important determinant of reduced serum paraoxonase activity in premenopausal women. Hum Reprod 2006;21:3157-61.
- 32. Bragatto FB, Barbosa CP, Christofolini DM, Peluso C, dos Santos AA, Mafra FA, et al. There is no relationship between Paraoxonase serum level activity in women with endometriosis and the stage of the disease: an observational study. Reprod Health 2013;10:32.
- 33. Younis A, Hawkins K, Mahini H, Butler W, Garelnabi M. Serum tumor necrosis factor-α, interleukin-6, monocyte chemotactic protein-1 and paraoxonase-1 profiles in women with endometriosis, PCOS, or unexplained infertility. J Assist Reprod Genet 2014;31:1445-51.
| APA | TASKAN T, TURAN T, iltemir duvan c, GONENÇ A (2023). Effect of Fetuin-A and oxidative stress on the occurrence of unexplained infertility. , 113 - 119. 10.4274/tjod.galenos.2023.87936 |
| Chicago | TASKAN TUBA,TURAN TAYLAN,iltemir duvan candan,GONENÇ AYMELEK Effect of Fetuin-A and oxidative stress on the occurrence of unexplained infertility. (2023): 113 - 119. 10.4274/tjod.galenos.2023.87936 |
| MLA | TASKAN TUBA,TURAN TAYLAN,iltemir duvan candan,GONENÇ AYMELEK Effect of Fetuin-A and oxidative stress on the occurrence of unexplained infertility. , 2023, ss.113 - 119. 10.4274/tjod.galenos.2023.87936 |
| AMA | TASKAN T,TURAN T,iltemir duvan c,GONENÇ A Effect of Fetuin-A and oxidative stress on the occurrence of unexplained infertility. . 2023; 113 - 119. 10.4274/tjod.galenos.2023.87936 |
| Vancouver | TASKAN T,TURAN T,iltemir duvan c,GONENÇ A Effect of Fetuin-A and oxidative stress on the occurrence of unexplained infertility. . 2023; 113 - 119. 10.4274/tjod.galenos.2023.87936 |
| IEEE | TASKAN T,TURAN T,iltemir duvan c,GONENÇ A "Effect of Fetuin-A and oxidative stress on the occurrence of unexplained infertility." , ss.113 - 119, 2023. 10.4274/tjod.galenos.2023.87936 |
| ISNAD | TASKAN, TUBA vd. "Effect of Fetuin-A and oxidative stress on the occurrence of unexplained infertility". (2023), 113-119. https://doi.org/10.4274/tjod.galenos.2023.87936 |
| APA | TASKAN T, TURAN T, iltemir duvan c, GONENÇ A (2023). Effect of Fetuin-A and oxidative stress on the occurrence of unexplained infertility. Turkish Journal of Obstetrics and Gynecology, 20(2), 113 - 119. 10.4274/tjod.galenos.2023.87936 |
| Chicago | TASKAN TUBA,TURAN TAYLAN,iltemir duvan candan,GONENÇ AYMELEK Effect of Fetuin-A and oxidative stress on the occurrence of unexplained infertility. Turkish Journal of Obstetrics and Gynecology 20, no.2 (2023): 113 - 119. 10.4274/tjod.galenos.2023.87936 |
| MLA | TASKAN TUBA,TURAN TAYLAN,iltemir duvan candan,GONENÇ AYMELEK Effect of Fetuin-A and oxidative stress on the occurrence of unexplained infertility. Turkish Journal of Obstetrics and Gynecology, vol.20, no.2, 2023, ss.113 - 119. 10.4274/tjod.galenos.2023.87936 |
| AMA | TASKAN T,TURAN T,iltemir duvan c,GONENÇ A Effect of Fetuin-A and oxidative stress on the occurrence of unexplained infertility. Turkish Journal of Obstetrics and Gynecology. 2023; 20(2): 113 - 119. 10.4274/tjod.galenos.2023.87936 |
| Vancouver | TASKAN T,TURAN T,iltemir duvan c,GONENÇ A Effect of Fetuin-A and oxidative stress on the occurrence of unexplained infertility. Turkish Journal of Obstetrics and Gynecology. 2023; 20(2): 113 - 119. 10.4274/tjod.galenos.2023.87936 |
| IEEE | TASKAN T,TURAN T,iltemir duvan c,GONENÇ A "Effect of Fetuin-A and oxidative stress on the occurrence of unexplained infertility." Turkish Journal of Obstetrics and Gynecology, 20, ss.113 - 119, 2023. 10.4274/tjod.galenos.2023.87936 |
| ISNAD | TASKAN, TUBA vd. "Effect of Fetuin-A and oxidative stress on the occurrence of unexplained infertility". Turkish Journal of Obstetrics and Gynecology 20/2 (2023), 113-119. https://doi.org/10.4274/tjod.galenos.2023.87936 |
