TY  - JOUR
TI  - Effect of Fetuin-A and oxidative stress on the occurrence of unexplained infertility
AB  - Objective: Unexplained infertility refers to a diagnosis in which all standard examinations are usually normal and is statistically seen in approximately 30-40% of infertile couples and endometriosis encountered in 25-50% of patients with unexplained infertility. Unexplained infertility is thought to be closely associated with endometriosis and serum and peritoneal fluid levels of Fetuin-A is increased in patients with endometriosis. Fetuin-A is proposed as a diagnostic marker for endometriosis and has anti-inflammatory effects on several diseases. Oxidative stress also is central to the etiopathogenesis of infertility in women. The aim of this study was to evaluate serum Fetuin-A and oxidative stress parameter concentrations impact on unexplained infertility. Materials and Methods: In the study, serum Fetuin-A, IL-1β, CA I, TAS, TOS levels, and PON and ARE enzyme activities were measured using the Enzyme-Linked ImmunoSorbent Assay in the sera of diagnosed unexplained infertility females (n=44) and controls (n=41). Results: There was no statistically significant difference between unexplained infertile patients and control groups in terms of serum IL-1β, CA I, OSI, and PON levels (p>0.05). Serum Fetuin-A and ARE levels were significantly higher in unexplained infertility compared with the control, whereas serum TAS and TOS levels were lower (p<0.05, p<0.01, p<0.05, p<0.05, respectively). Conclusion: It is thought that increased Fetuin-A levels may be a response to the inflammatory process and increased ARE activity may be a sign of the impaired oxidant-antioxidant balance in unexplained infertility. This may contribute to the pathogenesis of infertility, and the data obtained will make a significant contribution to new works to be done in this sense.
AU  - TASKAN, TUBA
AU  - GONENÇ, AYMELEK
AU  - iltemir duvan, candan
AU  - TURAN, TAYLAN
DO  - 10.4274/tjod.galenos.2023.87936
PY  - 2023
JO  - Turkish Journal of Obstetrics and Gynecology
VL  - 20
IS  - 2
SN  - 2149-9322
SP  - 113
EP  - 119
DB  - TRDizin
UR  - http://search/yayin/detay/1179890
ER  -