TY  - JOUR
TI  - Wound healing effects of bee venom on adipose tissue derived mesenchymal stem cells
AB  - The objective of this study is to determine the effects of bee venom on the proliferation capacity of mesenchymal stem cells and wound healing. For this purpose, mesenchymal stem cells were isolated from canine adipose tissue and bee venom samples were collected from Apis mellifera anatoliaca in Muğla province of Türkiye. Cell viability test was performed on mesenchymal stem cells exposed to various concentrations (40 ppm, 20 ppm, 10 ppm, 5 ppm, 2.5 ppm, 1.25 ppm, 0.625 ppm and 0.312 ppm) of bee venom. And wound healing test was performed on cells treated with the doses (5 ppm, 2.5 ppm, 1.25 ppm, 0.625 ppm) and imaged every two hours for 16 hours. According to the results of our study's cell proliferation assay and wound healing test, bee venom had no proliferative effect on mesenchymal stem cells within the defined dose range. The study's outcomes may be enhanced by investigating the effect of bee venom on mesenchymal stem cells in combination with other substances or by improving the bee venom's purification process. Even while we have a better understanding of the mechanisms of action of bee venom components, there are still a lot of unanswered questions on the subject.  It is believed that figuring out how bee venom affects wound healing may be useful for advancing wound care in both veterinary and human medicine.
AU  - Sevin, Sedat
AU  - ÖZGENÇ, Özge
DO  - 10.33188/vetheder.1183380
PY  - 2023
JO  - Veteriner Hekimler Derneği Dergisi
VL  - 94
IS  - 1
SN  - 0377-6395
SP  - 59
EP  - 66
DB  - TRDizin
UR  - http://search/yayin/detay/1181027
ER  -