The effects of ethanol extract of Punica granatum L. peel on the testis damage induced by diabetes in rats

APAYDIN YILDIRIM, BETUL; yildirim, Serkan; OMUR, Ali; akarsu, serkan ali

doi:10.24880/maeuvfd.1075862

The effects of ethanol extract of Punica granatum L. peel on the testis damage induced by diabetes in rats

Ali Doğan ÖMÜR, (Atatürk Üniversitesi, Veteriner Fakültesi, Üreme ve Suni Tohumlama Anabilim Dalı, Erzurum, Türkiye)

Betül APAYDIN YILDIRIM, (Atatürk Üniversitesi, Veteriner Fakültesi, Biyokimya Anabilim Dalı, Erzurum, Türkiye)

Serkan YILDIRIM, (Atatürk Üniversitesi, Veteriner Fakültesi, Patoloji Anabilim Dalı, Erzurum, Türkiye)

Serkan Ali AKARSU (Kahramanmaraş İstiklal Üniversitesi, Elbistan Meslek Yüksekokulu, Kahramanmaraş, Türkiye)

Mehmet Akif Ersoy Üniversitesi Veteriner Fakültesi Dergisi

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Yıl: 2023 Cilt: 8 Sayı: 1 Sayfa Aralığı: 1 - 7 Metin Dili: İngilizce DOI: 10.24880/maeuvfd.1075862 İndeks Tarihi: 21-09-2023

The effects of ethanol extract of Punica granatum L. peel on the testis damage induced by diabetes in rats

Öz:

The aim of this study was to determine the effect of ethanol extract of Punica granatum L. Peel on biochemical and histopathological changes in blood and testicular tissue in rats with experimental diabetes. A total of twenty-eight male Sprague-Dawley rats, 7 rats in each group, were used in this study. Group 1; peros physiological saline to the rat, Group 2; STZ 60 mg/kg/IP single dose, Group 3; PGE 10 mg/kg/20days/peros, Group 4; STZ as 60 mg/kg/IP + PGE 10 mg/kg/20days/peros. After the end of the experimental procedure, the rats were sacrificed, blood and testicular tissues were taken, and biochemical and histopathological examinations were performed. The administrati- on of PGE was shown that the activities of CAT, SOD, GPx and GSH increased and the levels of MDA decreased in diabetic rats. Compared to the diabetic and control groups, the treatment group decreased the LPO level and improved the antioxidant activity in plasma and testicular tissues. His- topathological examination of testicular tissues in the group 2 is revealed edema in the intertubular spaces, thinning of the tubule walls due to diminished spermatocytes in the walls of the seminife- rous tubules and severe degenerative and necrotic changes in spermatocytes. These changes were found to be very mild in group 4. According to immunohistochemical findings, in group 2, caspase 3 expression was intensely expressed in spermatocytes. As a result, it was observed that Punica gra-natum L. bark extract strengthened antioxidant defense and reduced oxidative stress in diabetic rats.

Anahtar Kelime: Diabetes Oxidative stress Rat Streptozotocin Punica Granatum L. peel

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	OMUR A, APAYDIN YILDIRIM B, yildirim S, akarsu s (2023). The effects of ethanol extract of Punica granatum L. peel on the testis damage induced by diabetes in rats. , 1 - 7. 10.24880/maeuvfd.1075862
Chicago	OMUR Ali,APAYDIN YILDIRIM BETUL,yildirim Serkan,akarsu serkan ali The effects of ethanol extract of Punica granatum L. peel on the testis damage induced by diabetes in rats. (2023): 1 - 7. 10.24880/maeuvfd.1075862
MLA	OMUR Ali,APAYDIN YILDIRIM BETUL,yildirim Serkan,akarsu serkan ali The effects of ethanol extract of Punica granatum L. peel on the testis damage induced by diabetes in rats. , 2023, ss.1 - 7. 10.24880/maeuvfd.1075862
AMA	OMUR A,APAYDIN YILDIRIM B,yildirim S,akarsu s The effects of ethanol extract of Punica granatum L. peel on the testis damage induced by diabetes in rats. . 2023; 1 - 7. 10.24880/maeuvfd.1075862
Vancouver	OMUR A,APAYDIN YILDIRIM B,yildirim S,akarsu s The effects of ethanol extract of Punica granatum L. peel on the testis damage induced by diabetes in rats. . 2023; 1 - 7. 10.24880/maeuvfd.1075862
IEEE	OMUR A,APAYDIN YILDIRIM B,yildirim S,akarsu s "The effects of ethanol extract of Punica granatum L. peel on the testis damage induced by diabetes in rats." , ss.1 - 7, 2023. 10.24880/maeuvfd.1075862
ISNAD	OMUR, Ali vd. "The effects of ethanol extract of Punica granatum L. peel on the testis damage induced by diabetes in rats". (2023), 1-7. https://doi.org/10.24880/maeuvfd.1075862

APA	OMUR A, APAYDIN YILDIRIM B, yildirim S, akarsu s (2023). The effects of ethanol extract of Punica granatum L. peel on the testis damage induced by diabetes in rats. Mehmet Akif Ersoy Üniversitesi Veteriner Fakültesi Dergisi, 8(1), 1 - 7. 10.24880/maeuvfd.1075862
Chicago	OMUR Ali,APAYDIN YILDIRIM BETUL,yildirim Serkan,akarsu serkan ali The effects of ethanol extract of Punica granatum L. peel on the testis damage induced by diabetes in rats. Mehmet Akif Ersoy Üniversitesi Veteriner Fakültesi Dergisi 8, no.1 (2023): 1 - 7. 10.24880/maeuvfd.1075862
MLA	OMUR Ali,APAYDIN YILDIRIM BETUL,yildirim Serkan,akarsu serkan ali The effects of ethanol extract of Punica granatum L. peel on the testis damage induced by diabetes in rats. Mehmet Akif Ersoy Üniversitesi Veteriner Fakültesi Dergisi, vol.8, no.1, 2023, ss.1 - 7. 10.24880/maeuvfd.1075862
AMA	OMUR A,APAYDIN YILDIRIM B,yildirim S,akarsu s The effects of ethanol extract of Punica granatum L. peel on the testis damage induced by diabetes in rats. Mehmet Akif Ersoy Üniversitesi Veteriner Fakültesi Dergisi. 2023; 8(1): 1 - 7. 10.24880/maeuvfd.1075862
Vancouver	OMUR A,APAYDIN YILDIRIM B,yildirim S,akarsu s The effects of ethanol extract of Punica granatum L. peel on the testis damage induced by diabetes in rats. Mehmet Akif Ersoy Üniversitesi Veteriner Fakültesi Dergisi. 2023; 8(1): 1 - 7. 10.24880/maeuvfd.1075862
IEEE	OMUR A,APAYDIN YILDIRIM B,yildirim S,akarsu s "The effects of ethanol extract of Punica granatum L. peel on the testis damage induced by diabetes in rats." Mehmet Akif Ersoy Üniversitesi Veteriner Fakültesi Dergisi, 8, ss.1 - 7, 2023. 10.24880/maeuvfd.1075862
ISNAD	OMUR, Ali vd. "The effects of ethanol extract of Punica granatum L. peel on the testis damage induced by diabetes in rats". Mehmet Akif Ersoy Üniversitesi Veteriner Fakültesi Dergisi 8/1 (2023), 1-7. https://doi.org/10.24880/maeuvfd.1075862