TY  - JOUR
TI  - The effects of ethanol extract of Punica granatum L. peel on the testis damage induced by diabetes in rats
AB  - The aim of this study was to determine the effect of ethanol extract of Punica granatum L. Peel on biochemical and histopathological changes in blood and testicular tissue in rats with experimental diabetes. A total of twenty-eight male Sprague-Dawley rats, 7 rats in each group, were used in this study. Group 1; peros physiological saline to the rat, Group 2; STZ 60 mg/kg/IP single dose, Group 3; PGE 10 mg/kg/20days/peros, Group 4; STZ as 60 mg/kg/IP + PGE 10 mg/kg/20days/peros. After the end of the experimental procedure, the rats were sacrificed, blood and testicular tissues were taken, and biochemical and histopathological examinations were performed. The administrati- on of PGE was shown that the activities of CAT, SOD, GPx and GSH increased and the levels of MDA decreased in diabetic rats. Compared to the diabetic and control groups, the treatment group decreased the LPO level and improved the antioxidant activity in plasma and testicular tissues. His- topathological examination of testicular tissues in the group 2 is revealed edema in the intertubular spaces, thinning of the tubule walls due to diminished spermatocytes in the walls of the seminife- rous tubules and severe degenerative and necrotic changes in spermatocytes. These changes were found to be very mild in group 4. According to immunohistochemical findings, in group 2, caspase 3 expression was intensely expressed in spermatocytes. As a result, it was observed that Punica gra-natum L. bark extract strengthened antioxidant defense and reduced oxidative stress in diabetic rats.
AU  - APAYDIN YILDIRIM, BETUL
AU  - yildirim, Serkan
AU  - OMUR, Ali
AU  - akarsu, serkan ali
DO  - 10.24880/maeuvfd.1075862
PY  - 2023
JO  - Mehmet Akif Ersoy Üniversitesi Veteriner Fakültesi Dergisi
VL  - 8
IS  - 1
SN  - 2458-9268
SP  - 1
EP  - 7
DB  - TRDizin
UR  - http://search/yayin/detay/1181392
ER  -