Primary mediastinal large B-cell lymphoma that occurs in an unexpected localization
Yıl: 2023 Cilt: 48 Sayı: 1 Sayfa Aralığı: 304 - 305 Metin Dili: İngilizce DOI: 10.17826/cumj.1220032 İndeks Tarihi: 20-06-2023
Primary mediastinal large B-cell lymphoma that occurs in an unexpected localization
Öz: Primary mediastinal large B-cell lymphoma (PMLBCL) is a mature aggressive large B-cell lymphoma of putative thymic B-cell origin arising in the mediastinum, with distinctive clinical, immunophenotypic, genotypic, and molecular features. Cases that arise outside the mediastinum are very uncommon. A 27-year-old woman presented with mass which had an extramedullary, extradural component at the right T5-6 foramina indenting to the spinal canal, extending craniocaudally from the middle mediastinum to the level of the aortic hiatus. Pathological examination of the mass revealed atypical lymphoid cells with medium-large size, eosinophilic and clear cytoplasm In our case CD23 and MAL expression with morphological findings supported PMLBCL. PMLBCL may be seen with abnormal localization and clinical presentation. Immunohistochemical profile including MAL is helpful to detect these cases.
Anahtar Kelime: Beklenmedik bir lokalizasyonda ortaya çıkan primer mediastinal büyük B hücreli lenfoma
Öz: Primer mediastinal büyük B hücreli lenfoma (PMLBCL), mediastende ortaya çıkan, kendine özgü klinik, immünofenotipik, genotipik ve moleküler özelliklere sahip, varsayılan timik B hücresi kökenli olgun agresif bir büyük B hücreli lenfomadır. Mediasten dışında ortaya çıkan vakalar çok nadirdir. Yirmi yedi yaşında bir kadın hasta, sağ T5-6 foraminasında spinal kanala girinti yapan, orta mediastenden aortik hiatus seviyesine kadar kraniokaudal olarak uzanan ekstramedüller, ekstradural komponenti olan kitle ile başvurdu. Kitlenin patolojik incelemesinde orta-büyük boyutlu, eozinofilik ve berrak sitoplazmalı atipik lenfoid hücreler görüldü Olgumuzda CD23 ve MAL ekspresyonu ile morfolojik bulgular PMLBCL'yi destekledi. PMLBCL anormal lokalizasyon ve klinik tablo ile görülebilir. MAL'ı da içeren immünohistokimyasal profil bu olguları saptamada yardımcıdır.
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| APA | Inceman M, Pehlivan U, Toyran T, ÖZDEK R, Paydas S (2023). Primary mediastinal large B-cell lymphoma that occurs in an unexpected localization. , 304 - 305. 10.17826/cumj.1220032 |
| Chicago | Inceman Merve,Pehlivan Umur Anil,Toyran Tugba,ÖZDEK RECEP,Paydas Semra Primary mediastinal large B-cell lymphoma that occurs in an unexpected localization. (2023): 304 - 305. 10.17826/cumj.1220032 |
| MLA | Inceman Merve,Pehlivan Umur Anil,Toyran Tugba,ÖZDEK RECEP,Paydas Semra Primary mediastinal large B-cell lymphoma that occurs in an unexpected localization. , 2023, ss.304 - 305. 10.17826/cumj.1220032 |
| AMA | Inceman M,Pehlivan U,Toyran T,ÖZDEK R,Paydas S Primary mediastinal large B-cell lymphoma that occurs in an unexpected localization. . 2023; 304 - 305. 10.17826/cumj.1220032 |
| Vancouver | Inceman M,Pehlivan U,Toyran T,ÖZDEK R,Paydas S Primary mediastinal large B-cell lymphoma that occurs in an unexpected localization. . 2023; 304 - 305. 10.17826/cumj.1220032 |
| IEEE | Inceman M,Pehlivan U,Toyran T,ÖZDEK R,Paydas S "Primary mediastinal large B-cell lymphoma that occurs in an unexpected localization." , ss.304 - 305, 2023. 10.17826/cumj.1220032 |
| ISNAD | Inceman, Merve vd. "Primary mediastinal large B-cell lymphoma that occurs in an unexpected localization". (2023), 304-305. https://doi.org/10.17826/cumj.1220032 |
| APA | Inceman M, Pehlivan U, Toyran T, ÖZDEK R, Paydas S (2023). Primary mediastinal large B-cell lymphoma that occurs in an unexpected localization. Cukurova Medical Journal, 48(1), 304 - 305. 10.17826/cumj.1220032 |
| Chicago | Inceman Merve,Pehlivan Umur Anil,Toyran Tugba,ÖZDEK RECEP,Paydas Semra Primary mediastinal large B-cell lymphoma that occurs in an unexpected localization. Cukurova Medical Journal 48, no.1 (2023): 304 - 305. 10.17826/cumj.1220032 |
| MLA | Inceman Merve,Pehlivan Umur Anil,Toyran Tugba,ÖZDEK RECEP,Paydas Semra Primary mediastinal large B-cell lymphoma that occurs in an unexpected localization. Cukurova Medical Journal, vol.48, no.1, 2023, ss.304 - 305. 10.17826/cumj.1220032 |
| AMA | Inceman M,Pehlivan U,Toyran T,ÖZDEK R,Paydas S Primary mediastinal large B-cell lymphoma that occurs in an unexpected localization. Cukurova Medical Journal. 2023; 48(1): 304 - 305. 10.17826/cumj.1220032 |
| Vancouver | Inceman M,Pehlivan U,Toyran T,ÖZDEK R,Paydas S Primary mediastinal large B-cell lymphoma that occurs in an unexpected localization. Cukurova Medical Journal. 2023; 48(1): 304 - 305. 10.17826/cumj.1220032 |
| IEEE | Inceman M,Pehlivan U,Toyran T,ÖZDEK R,Paydas S "Primary mediastinal large B-cell lymphoma that occurs in an unexpected localization." Cukurova Medical Journal, 48, ss.304 - 305, 2023. 10.17826/cumj.1220032 |
| ISNAD | Inceman, Merve vd. "Primary mediastinal large B-cell lymphoma that occurs in an unexpected localization". Cukurova Medical Journal 48/1 (2023), 304-305. https://doi.org/10.17826/cumj.1220032 |
