Frequency and Clinical Impact of Microsatellite Instability in Colorectal Dysplasia Subgroups

Ozturk, Ersin; Yılmazlar, Tuncay; GUREL, SELIM; Tekin, Cagla; Yerci, Ömer; Aksoy, Seçil; Ercelik, melis; Ugras, Nesrin; Isik, Ozgen

doi:10.4274/tjcd.galenos.2023.2023-1-10

Frequency and Clinical Impact of Microsatellite Instability in Colorectal Dysplasia Subgroups

Seçil AK AKSOY, (Bursa Uludağ Üniversitesi, İnegöl Meslek Yüksekokulu, Bursa, Türkiye)

Tuncay YILMAZLAR, (Bursa Uludağ Üniversitesi Tıp Fakültesi Genel Cerrahi Anabilim Dalı, Bursa, Türkiye)

melis Ercelik, (Bursa Uludağ Üniversitesi Tıp Fakültesi, Tıbbi Biyoloji Anabilim Dalı, Bursa, Türkiye)

Çağla TEKİN, (Bursa Uludağ Üniversitesi Tıp Fakültesi, Tıbbi Biyoloji Anabilim Dalı, Bursa, Türkiye)

Nesrin UĞRAŞ, (Bursa Uludağ Üniversitesi Tıp Fakültesi, Patoloji Anabilim Dalı, Bursa, Türkiye)

Ömer YERCİ, (Bursa Uludağ Üniversitesi Tıp Fakültesi, Patoloji Anabilim Dalı, Bursa, Türkiye)

Ersin ÖZTÜRK, (Bursa Medicana Hastanesi, Cerrahi Kliniği, Bursa, Türkiye)

Selim GÜREL, (Bursa Uludağ Üniversitesi Tıp Fakültesi, Gastroenteroloji Anabilim Dalı, Bursa, Türkiye)

Özgen IŞIK (Bursa Uludağ Üniversitesi Tıp Fakültesi Genel Cerrahi Anabilim Dalı, Bursa, Türkiye)

Türk Kolon ve Rektum Hastalıkları Dergisi

10 7

Yıl: 2023 Cilt: 33 Sayı: 2 Sayfa Aralığı: 43 - 47 Metin Dili: Türkçe DOI: 10.4274/tjcd.galenos.2023.2023-1-10 İndeks Tarihi: 02-07-2023

Frequency and Clinical Impact of Microsatellite Instability in Colorectal Dysplasia Subgroups

Öz:

Aim: The risk of colorectal cancer development associated with low-grade dysplasia (LGD) and high-grade dysplasia (HGD) colon polyps at baseline polypectomy remains unclear. In this study, we investigated the role of microsatellite instability (MSI) in the formation and prognosis of dysplasia. Method: In the study, 40 polyps diagnosed as HGD, and 40 polyps diagnosed as LGD were evaluated according to the revised Vienna criteria (2015) as a result of polypectomy. MSI analysis was performed by fragment analysis using five different primers. Results: Three of the polyps diagnosed with LGD and eight of the polyps diagnosed with HGD turned into cancer during the follow-up period. The rate of MSI in sporadic colorectal dysplasia was determined as 36.3. A significant correlation was found between MSI status and polyp recurrence within the five-year follow-up period after polypectomy. Conclusion: In our study, it was determined that LGD and HGDs with MSI can recur, but polypectomy may be effective in preventing cancer formation in cases of dysplasia with MSI.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Aksoy S, Yılmazlar T, Ercelik m, Tekin C, Ugras N, Yerci Ö, Ozturk E, GUREL S, Isik O (2023). Frequency and Clinical Impact of Microsatellite Instability in Colorectal Dysplasia Subgroups. , 43 - 47. 10.4274/tjcd.galenos.2023.2023-1-10
Chicago	Aksoy Seçil,Yılmazlar Tuncay,Ercelik melis,Tekin Cagla,Ugras Nesrin,Yerci Ömer,Ozturk Ersin,GUREL SELIM,Isik Ozgen Frequency and Clinical Impact of Microsatellite Instability in Colorectal Dysplasia Subgroups. (2023): 43 - 47. 10.4274/tjcd.galenos.2023.2023-1-10
MLA	Aksoy Seçil,Yılmazlar Tuncay,Ercelik melis,Tekin Cagla,Ugras Nesrin,Yerci Ömer,Ozturk Ersin,GUREL SELIM,Isik Ozgen Frequency and Clinical Impact of Microsatellite Instability in Colorectal Dysplasia Subgroups. , 2023, ss.43 - 47. 10.4274/tjcd.galenos.2023.2023-1-10
AMA	Aksoy S,Yılmazlar T,Ercelik m,Tekin C,Ugras N,Yerci Ö,Ozturk E,GUREL S,Isik O Frequency and Clinical Impact of Microsatellite Instability in Colorectal Dysplasia Subgroups. . 2023; 43 - 47. 10.4274/tjcd.galenos.2023.2023-1-10
Vancouver	Aksoy S,Yılmazlar T,Ercelik m,Tekin C,Ugras N,Yerci Ö,Ozturk E,GUREL S,Isik O Frequency and Clinical Impact of Microsatellite Instability in Colorectal Dysplasia Subgroups. . 2023; 43 - 47. 10.4274/tjcd.galenos.2023.2023-1-10
IEEE	Aksoy S,Yılmazlar T,Ercelik m,Tekin C,Ugras N,Yerci Ö,Ozturk E,GUREL S,Isik O "Frequency and Clinical Impact of Microsatellite Instability in Colorectal Dysplasia Subgroups." , ss.43 - 47, 2023. 10.4274/tjcd.galenos.2023.2023-1-10
ISNAD	Aksoy, Seçil vd. "Frequency and Clinical Impact of Microsatellite Instability in Colorectal Dysplasia Subgroups". (2023), 43-47. https://doi.org/10.4274/tjcd.galenos.2023.2023-1-10

APA	Aksoy S, Yılmazlar T, Ercelik m, Tekin C, Ugras N, Yerci Ö, Ozturk E, GUREL S, Isik O (2023). Frequency and Clinical Impact of Microsatellite Instability in Colorectal Dysplasia Subgroups. Türk Kolon ve Rektum Hastalıkları Dergisi, 33(2), 43 - 47. 10.4274/tjcd.galenos.2023.2023-1-10
Chicago	Aksoy Seçil,Yılmazlar Tuncay,Ercelik melis,Tekin Cagla,Ugras Nesrin,Yerci Ömer,Ozturk Ersin,GUREL SELIM,Isik Ozgen Frequency and Clinical Impact of Microsatellite Instability in Colorectal Dysplasia Subgroups. Türk Kolon ve Rektum Hastalıkları Dergisi 33, no.2 (2023): 43 - 47. 10.4274/tjcd.galenos.2023.2023-1-10
MLA	Aksoy Seçil,Yılmazlar Tuncay,Ercelik melis,Tekin Cagla,Ugras Nesrin,Yerci Ömer,Ozturk Ersin,GUREL SELIM,Isik Ozgen Frequency and Clinical Impact of Microsatellite Instability in Colorectal Dysplasia Subgroups. Türk Kolon ve Rektum Hastalıkları Dergisi, vol.33, no.2, 2023, ss.43 - 47. 10.4274/tjcd.galenos.2023.2023-1-10
AMA	Aksoy S,Yılmazlar T,Ercelik m,Tekin C,Ugras N,Yerci Ö,Ozturk E,GUREL S,Isik O Frequency and Clinical Impact of Microsatellite Instability in Colorectal Dysplasia Subgroups. Türk Kolon ve Rektum Hastalıkları Dergisi. 2023; 33(2): 43 - 47. 10.4274/tjcd.galenos.2023.2023-1-10
Vancouver	Aksoy S,Yılmazlar T,Ercelik m,Tekin C,Ugras N,Yerci Ö,Ozturk E,GUREL S,Isik O Frequency and Clinical Impact of Microsatellite Instability in Colorectal Dysplasia Subgroups. Türk Kolon ve Rektum Hastalıkları Dergisi. 2023; 33(2): 43 - 47. 10.4274/tjcd.galenos.2023.2023-1-10
IEEE	Aksoy S,Yılmazlar T,Ercelik m,Tekin C,Ugras N,Yerci Ö,Ozturk E,GUREL S,Isik O "Frequency and Clinical Impact of Microsatellite Instability in Colorectal Dysplasia Subgroups." Türk Kolon ve Rektum Hastalıkları Dergisi, 33, ss.43 - 47, 2023. 10.4274/tjcd.galenos.2023.2023-1-10
ISNAD	Aksoy, Seçil vd. "Frequency and Clinical Impact of Microsatellite Instability in Colorectal Dysplasia Subgroups". Türk Kolon ve Rektum Hastalıkları Dergisi 33/2 (2023), 43-47. https://doi.org/10.4274/tjcd.galenos.2023.2023-1-10