TY  - JOUR
TI  - Frequency and Clinical Impact of Microsatellite Instability in Colorectal Dysplasia Subgroups
AB  - Aim: The risk of colorectal cancer development associated with low-grade dysplasia (LGD) and high-grade dysplasia (HGD) colon polyps at baseline polypectomy remains unclear. In this study, we investigated the role of microsatellite instability (MSI) in the formation and prognosis of dysplasia. Method: In the study, 40 polyps diagnosed as HGD, and 40 polyps diagnosed as LGD were evaluated according to the revised Vienna criteria (2015) as a result of polypectomy. MSI analysis was performed by fragment analysis using five different primers. Results: Three of the polyps diagnosed with LGD and eight of the polyps diagnosed with HGD turned into cancer during the follow-up period. The rate of MSI in sporadic colorectal dysplasia was determined as 36.3. A significant correlation was found between MSI status and polyp recurrence within the five-year follow-up period after polypectomy. Conclusion: In our study, it was determined that LGD and HGDs with MSI can recur, but polypectomy may be effective in preventing cancer formation in cases of dysplasia with MSI.
AU  - Ozturk, Ersin
AU  - Yılmazlar, Tuncay
AU  - GUREL, SELIM
AU  - Tekin, Cagla
AU  - Yerci, Ömer
AU  - Aksoy, Seçil
AU  - Ercelik, melis
AU  - Ugras, Nesrin
AU  - Isik, Ozgen
DO  - 10.4274/tjcd.galenos.2023.2023-1-10
PY  - 2023
JO  - Türk Kolon ve Rektum Hastalıkları Dergisi
VL  - 33
IS  - 2
SN  - 2536-4898
SP  - 43
EP  - 47
DB  - TRDizin
UR  - http://search/yayin/detay/1182839
ER  -