Yıl: 2023 Cilt: 29 Sayı: 2 Sayfa Aralığı: 46 - 49 Metin Dili: İngilizce DOI: 10.4274/ArchEpilepsy.2023.221021 İndeks Tarihi: 02-07-2023

Risk Factors for Clinically Overt Hypothyroidism in Unselected Population of Adult Epilepsy Patients

Öz:
Objective: This study aimed to investigate the risk factors for hypothyroidism in patients with adult epilepsy patients. Methods: Hospital charts of 530 patients were reviewed retrospectively. Patients with a definite diagnosis of hypothyroidism with persistent adherence to antiseizure medications (ASM) were included. An age and gender-matched group of 110 patients was selected as the control group. Results: The rate of hypothyroidism was significantly higher in patients with epilepsy (p=0.01). The patients with epilepsy were separated into two groups-the patients with and without hypothyroidism. The distribution of other neurologic disorders was similar in epilepsy patients with and without hypothyroidism (p=0.46). The comparison of the two groups showed that, independent of the ASM type, receiving any polytherapy regimen was a significant risk factor for hypothyroidism (p=0.02) and epilepsy patients with hypothyroidism had a longer duration of epilepsy (p=0.03). Logistic regression analysis revealed that the only independent risk factor for hypothyroidism was being on a polytherapy regimen (p=0.02). Conclusion: In this study, we found two major results: i) compared with an age and gender-matched control group, epilepsy is a major risk factor for hypothyroidism, ii) independent of the ASM type, receiving a polytherapy regimen is a predictive risk factor for hypothyroidism.
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  • 1. Fiest KM, Sauro KM, Wiebe S, et al. Prevalence and incidence of epilepsy: A systematic review and meta-analysis of international studies. Neurology. 2017;88(3):296-303. Erratum in: Neurology. 2017;89(6):642. [CrossRef]
  • 2. Tombini M, Assenza G, Quintiliani L, Ricci L, Lanzone J, Di Lazzaro V. Epilepsy and quality of life: what does really matter? Neurol Sci. 2021;42(9):3757-3765. [CrossRef]
  • 3. Sajobi TT, Josephson CB, Sawatzky R, et al. Quality of Life in Epilepsy: Same questions, but different meaning to different people. Epilepsia. 2021;62(9):2094-2102. [CrossRef]
  • 4. Thijs RD, Surges R, O’Brien TJ, Sander JW. Epilepsy in adults. Lancet. 2019;393(10172):689-701. [CrossRef]
  • 5. Keezer MR, Bell GS, Neligan A, Novy J, Sander JW. Cause of death and predictors of mortality in a community-based cohort of people with epilepsy. Neurology. 2016;86(8):704-712. [CrossRef]
  • 6. Rochtus AM, Herijgers D, Jansen K, Decallonne B. Antiseizure medications and thyroid hormone homeostasis: Literature review and practical recommendations. Epilepsia. 2022;63(2):259-270. [CrossRef]
  • 7. Hamed SA. The effect of antiepileptic drugs on thyroid hormonal function: causes and implications. Expert Rev Clin Pharmacol. 2015;8(6):741-750. [CrossRef]
  • 8. Han Y, Yang J, Zhong R, Guo X, Cai M, Lin W. Side effects of long-term oral anti-seizure drugs on thyroid hormones in patients with epilepsy: a systematic review and network meta-analysis. Neurol Sci. 2022;43(9):5217- 5227. [CrossRef]
  • 9. Shih JJ, Whitlock JB, Chimato N, Vargas E, Karceski SC, Frank RD. Epilepsy treatment in adults and adolescents: Expert opinion, 2016. Epilepsy Behav. 2017;69:186-222. [CrossRef]
  • 10. Einarsdottir MJ, Olafsson E, Sigurjonsdottir HA. Antiepileptic drugs are associated with central hypothyroidism. Acta Neurol Scand. 2019;139(1):64-69. [CrossRef]
  • 11. Kanner AM, Bicchi MM. Antiseizure Medications for Adults With Epilepsy: A Review. JAMA. 2022;327(13):1269-1281. [CrossRef]
  • 12. Inoue K, Ritz B, Brent GA, Ebrahimi R, Rhee CM, Leung AM. Association of Subclinical Hypothyroidism and Cardiovascular Disease With Mortality. JAMA Netw Open. 2020;3(2):e1920745. [CrossRef]
  • 13. Biondi B, Cappola AR, Cooper DS. Subclinical Hypothyroidism: A Review. JAMA. 2019;322(2):153-160. [CrossRef]
  • 14. Verrotti A, Tambucci R, Di Francesco L, et al. The role of polytherapy in the management of epilepsy: suggestions for rational antiepileptic drug selection. Expert Rev Neurother. 2020;20(2):167-173. [CrossRef]
  • 15. Han JY, Lee IG, Shin S, Park J. Seizure duration may increase thyroid- stimulating hormone levels in children experiencing a seizure. J Int Med Res. 2020;48(5):300060519888401. [CrossRef]
  • 16. Bora I. The Connection Between Hormones and Antiepileptic Drugs. Epilepsi. 2018;24(Suppl. 1);51-59. [CrossRef]
APA CARKI BAL N, dogan e, Senol Y (2023). Risk Factors for Clinically Overt Hypothyroidism in Unselected Population of Adult Epilepsy Patients. , 46 - 49. 10.4274/ArchEpilepsy.2023.221021
Chicago CARKI BAL Naciye,dogan ebru apaydın,Senol Yesim Risk Factors for Clinically Overt Hypothyroidism in Unselected Population of Adult Epilepsy Patients. (2023): 46 - 49. 10.4274/ArchEpilepsy.2023.221021
MLA CARKI BAL Naciye,dogan ebru apaydın,Senol Yesim Risk Factors for Clinically Overt Hypothyroidism in Unselected Population of Adult Epilepsy Patients. , 2023, ss.46 - 49. 10.4274/ArchEpilepsy.2023.221021
AMA CARKI BAL N,dogan e,Senol Y Risk Factors for Clinically Overt Hypothyroidism in Unselected Population of Adult Epilepsy Patients. . 2023; 46 - 49. 10.4274/ArchEpilepsy.2023.221021
Vancouver CARKI BAL N,dogan e,Senol Y Risk Factors for Clinically Overt Hypothyroidism in Unselected Population of Adult Epilepsy Patients. . 2023; 46 - 49. 10.4274/ArchEpilepsy.2023.221021
IEEE CARKI BAL N,dogan e,Senol Y "Risk Factors for Clinically Overt Hypothyroidism in Unselected Population of Adult Epilepsy Patients." , ss.46 - 49, 2023. 10.4274/ArchEpilepsy.2023.221021
ISNAD CARKI BAL, Naciye vd. "Risk Factors for Clinically Overt Hypothyroidism in Unselected Population of Adult Epilepsy Patients". (2023), 46-49. https://doi.org/10.4274/ArchEpilepsy.2023.221021
APA CARKI BAL N, dogan e, Senol Y (2023). Risk Factors for Clinically Overt Hypothyroidism in Unselected Population of Adult Epilepsy Patients. Archives of epilepsy (Online), 29(2), 46 - 49. 10.4274/ArchEpilepsy.2023.221021
Chicago CARKI BAL Naciye,dogan ebru apaydın,Senol Yesim Risk Factors for Clinically Overt Hypothyroidism in Unselected Population of Adult Epilepsy Patients. Archives of epilepsy (Online) 29, no.2 (2023): 46 - 49. 10.4274/ArchEpilepsy.2023.221021
MLA CARKI BAL Naciye,dogan ebru apaydın,Senol Yesim Risk Factors for Clinically Overt Hypothyroidism in Unselected Population of Adult Epilepsy Patients. Archives of epilepsy (Online), vol.29, no.2, 2023, ss.46 - 49. 10.4274/ArchEpilepsy.2023.221021
AMA CARKI BAL N,dogan e,Senol Y Risk Factors for Clinically Overt Hypothyroidism in Unselected Population of Adult Epilepsy Patients. Archives of epilepsy (Online). 2023; 29(2): 46 - 49. 10.4274/ArchEpilepsy.2023.221021
Vancouver CARKI BAL N,dogan e,Senol Y Risk Factors for Clinically Overt Hypothyroidism in Unselected Population of Adult Epilepsy Patients. Archives of epilepsy (Online). 2023; 29(2): 46 - 49. 10.4274/ArchEpilepsy.2023.221021
IEEE CARKI BAL N,dogan e,Senol Y "Risk Factors for Clinically Overt Hypothyroidism in Unselected Population of Adult Epilepsy Patients." Archives of epilepsy (Online), 29, ss.46 - 49, 2023. 10.4274/ArchEpilepsy.2023.221021
ISNAD CARKI BAL, Naciye vd. "Risk Factors for Clinically Overt Hypothyroidism in Unselected Population of Adult Epilepsy Patients". Archives of epilepsy (Online) 29/2 (2023), 46-49. https://doi.org/10.4274/ArchEpilepsy.2023.221021