The relationship between body mass index and clinical properties/survival in patients with breast cancer

erdoğdu, batuhan; UTKAN, GÜNGOR

doi:10.18621/eurj.1099886

The relationship between body mass index and clinical properties/survival in patients with breast cancer

Batuhan Erdoğdu, (Hacettepe Üniversitesi, Tıp Fakültesi, Hematoloji Anabilim Dalı, Ankara, Türkiye)

Güngör Utkan (Ankara Üniversite, Tıp Fakültesi, Tıbbi Onkoloji Anabilim Dalı, Ankara, Türkiye)

The European Research Journal

4 2

Yıl: 2023 Cilt: 9 Sayı: 4 Sayfa Aralığı: 770 - 778 Metin Dili: İngilizce DOI: 10.18621/eurj.1099886 İndeks Tarihi: 05-07-2023

The relationship between body mass index and clinical properties/survival in patients with breast cancer

Öz:

Objectives: The aim of this study was to investigate relationship between body mass index (BMI) and recurrence/survival and to determine whether body mass index is a risk factor. Methods: A retrospective study of 125 patients with breast cancer was performed. Age, sex, menopausal situation, body mass index, tumor size, axillary lymph node involvement and number, tumor degree, hormone receptor situation, cerbB-2 overexpression, tumor grade, chemotherapy dose and treatments, radiotherapy, metastasis, comorbidity, total survival and time of death were evaluated. Patients were compared as BMI < 30 kg/m2 and BMI ≥ 30 kg/m2. Kaplan-Meier method and Log Rank test was utilized for the overall survival of patients. Results: In these 72 patients, 57.6% of patient’s body mass index BMI < 30 kg/m2 (non-obese) while 53 of the group (42.4%) BMI ≥ 30 kg/m2 (obese) were found in the group. The median follow-up was 158.32 months (95% CI: 130.45 to 186.19). The mean follow-up was 146 ± 46 months (95% Cl: 55.36-236.63) and 144 ± 28 months (95% CI: 88.19-199.81) for non-obese patients and obese patients respectively. Kaplan Meier plots were drawn for determination of the effect of body mass index in total survival. No significant difference was found statistically between two groups. Conclusions: No significant difference was found statistically between BMI and recurrence/death. The future studies with long term follow up are needed to investigate the effect of body mass index on recurrence and survival in patients with breast cancer.

Anahtar Kelime: Breast cancer body mass index survival relapse obesity

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

1. Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global Cancer Statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 2021;71:209-49.
2. Tanaka T, Decuzzi P, Cristofanilli M, Sakamoto JH, Tasciotti E, Robertson FM, et al. Nanotechnology for breast cancer therapy. Biomed Microdevices 2009;11:49-63.
3. Türkiye Kanser İstatistikleri 2017. [Available from: https://hsgm.saglik.gov.tr/depo/birimler/kanser-db/istatistik/Turkiye_Kanser_Istatistikleri_2017.pdf.
4. Pedersen RN, Esen BO, Mellemkjaer L, Christiansen P, Ejlertsen B, Lash TL, et al. The incidence of breast cancer recurrence 10-32 years after primary diagnosis. J Natl Cancer Inst 2022;114:391-9.
5. Kaidar-Person O, Bar-Sela G, Person B. The two major epidemics of the twenty-first century: obesity and cancer. Obes Surg 2011;21:1792-7.
6. Calle EE, Kaaks R. Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms. Nat Rev Cancer 2004;4:579-91.
7. Calle EE, Rodriguez C, Walker-Thurmond K, Thun MJ. Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. N Eng J Med 2003;348):1625-38.
8. Dignam JJ, Wieand K, Johnson KA, Fisher B, Xu L, Mamounas EP. Obesity, tamoxifen use, and outcomes in women with estrogen receptor-positive early-stage breast cancer. J Natl Cancer Inst 2003;95:1467-76.
9. Carmichael AR, Bendall S, Lockerbie L, Prescott RJ, Bates T. Does obesity compromise survival in women with breast cancer? Breast 2004;13:93-6.
10. Caan BJ, Emond JA, Natarajan L, Castillo A, Gunderson EP, Habel L, et al. Post-diagnosis weight gain and breast cancer recurrence in women with early stage breast cancer. Breast Cancer Res Treat 2006;99:47-57.
11. Lahmann PH, Hoffmann K, Allen N, van Gils CH, Khaw KT, Tehard B, et al. Body size and breast cancer risk: findings from the European Prospective Investigation into Cancer And Nutrition (EPIC). Int J Cancer 2004;111:762-71.
12. Sangrajrang S, Chaiwerawattana A, Ploysawang P, Nooklang K, Jamsri P, Somharnwong S. Obesity, diet and physical inactivity and risk of breast cancer in Thai women. Asian Pac J Cancer Prev 2013;14:7023-7.
13. Gelderblom H, Verweij J, Nooter K, Sparreboom A. Cremophor EL: the drawbacks and advantages of vehicle selection for drug formulation. Eur J Cancer 2001;37:1590-8.
14. AJCC Cancer Staging Manual. Greene FL, Page DL, Fleming ID, Fritz AG, Balch CM, Haller DG, et al., eds., 6th ed. Springer, 2022.
15. WHO Classification of Tumors. 5th Edition, 2019.
16. Biglia N, Peano E, Sgandurra P, Moggio G, Pecchio S, Maggiorotto F, et al. Body mass index (BMI) and breast cancer: impact on tumor histopathologic features, cancer subtypes and recurrence rate in pre and postmenopausal women. Gynecol Endocrinol 2013;29:263-7.
17. Turan Mİ, Karaca M, Çelik M, Yiğit D, Akgül N, Karaca ÖD, et al. [Relationship of breast cancer and molecular subtypes with menopausal status and body mass index]. Akdeniz Akdeniz Medical Journal 2022;8:186-93. [Article in Turkish]
18. Beypınar I, Kaya F, Demir H. The effect of the body composition to prognosis in young breast cancer patients. Akdeniz Medical Journal 2021;7:385-91.
19. de Azambuja E, McCaskill-Stevens W, Francis P, Quinaux E, Crown JP, Vicente M, et al. The effect of body mass index on overall and disease-free survival in node-positive breast cancer patients treated with docetaxel and doxorubicin-containing adjuvant chemotherapy: the experience of the BIG 02-98 trial. Breast Cancer Res Treat 2010;119:145-53.
20. Chan DS, Vieira AR, Aune D, Bandera EV, Greenwood DC, McTiernan A, et al. Body mass index and survival in women with breast cancer-systematic literature review and meta-analysis of 82 follow-up studies. Ann Oncol 2014;25:1901-14.
21. Dawood S, Lei X, Litton JK, Buchholz TA, Hortobagyi GN, Gonzalez-Angulo AM. Impact of body mass index on survival outcome among women with early stage triple-negative breast cancer. Clin Breast Cancer 2012;12:364-72.
22. Ademuyiwa FO, Groman A, O'Connor T, Ambrosone C, Watroba N, Edge SB. Impact of body mass index on clinical outcomes in triple-negative breast cancer. Cancer 2011;117:4132-40.
23. Ewertz M, Jensen MB, Gunnarsdottir KA, Hojris I, Jakobsen EH, Nielsen D, et al. Effect of obesity on prognosis after early-stage breast cancer. J Clin Oncol 2011;29:25-31.
24. Bardwell WA, Major JM, Rock CL, Newman VA, Thomson CA, Chilton JA, et al. Health-related quality of life in women previously treated for early-stage breast cancer. Psychooncology 2004;13:595-604.
25. Chan MF, Dowsett M, Folkerd E, Bingham S, Wareham N, Luben R, et al. Usual physical activity and endogenous sex hormones in postmenopausal women: the European prospective investigation into cancer-norfolk population study. Cancer Epidemiol Biomarkers Prev 2007;16:900-5.
26. Tobias D, Pan A, Hu FB. BMI and mortality among adults with incident type 2 diabetes. N Eng J Med 2014;370:1363-4.
27. Patterson RE, Flatt SW, Saquib N, Rock CL, Caan BJ, Parker BA, et al. Medical comorbidities predict mortality in women with a history of early stage breast cancer. Breast Cancer Res Treat 2010;122:859-65.
28. Cui Y, Whiteman MK, Flaws JA, Langenberg P, Tkaczuk KH, Bush TL. Body mass and stage of breast cancer at diagnosis. Int J Cancer 2002;98:279-83.
29. Hall HI, Coates RJ, Uhler RJ, Brinton LA, Gammon MD, Brogan D, et al. Stage of breast cancer in relation to body mass index and bra cup size. Int J Cancer 1999;82:23-7.

APA	erdoğdu b, UTKAN G (2023). The relationship between body mass index and clinical properties/survival in patients with breast cancer. , 770 - 778. 10.18621/eurj.1099886
Chicago	erdoğdu batuhan,UTKAN GÜNGOR The relationship between body mass index and clinical properties/survival in patients with breast cancer. (2023): 770 - 778. 10.18621/eurj.1099886
MLA	erdoğdu batuhan,UTKAN GÜNGOR The relationship between body mass index and clinical properties/survival in patients with breast cancer. , 2023, ss.770 - 778. 10.18621/eurj.1099886
AMA	erdoğdu b,UTKAN G The relationship between body mass index and clinical properties/survival in patients with breast cancer. . 2023; 770 - 778. 10.18621/eurj.1099886
Vancouver	erdoğdu b,UTKAN G The relationship between body mass index and clinical properties/survival in patients with breast cancer. . 2023; 770 - 778. 10.18621/eurj.1099886
IEEE	erdoğdu b,UTKAN G "The relationship between body mass index and clinical properties/survival in patients with breast cancer." , ss.770 - 778, 2023. 10.18621/eurj.1099886
ISNAD	erdoğdu, batuhan - UTKAN, GÜNGOR. "The relationship between body mass index and clinical properties/survival in patients with breast cancer". (2023), 770-778. https://doi.org/10.18621/eurj.1099886

APA	erdoğdu b, UTKAN G (2023). The relationship between body mass index and clinical properties/survival in patients with breast cancer. The European Research Journal, 9(4), 770 - 778. 10.18621/eurj.1099886
Chicago	erdoğdu batuhan,UTKAN GÜNGOR The relationship between body mass index and clinical properties/survival in patients with breast cancer. The European Research Journal 9, no.4 (2023): 770 - 778. 10.18621/eurj.1099886
MLA	erdoğdu batuhan,UTKAN GÜNGOR The relationship between body mass index and clinical properties/survival in patients with breast cancer. The European Research Journal, vol.9, no.4, 2023, ss.770 - 778. 10.18621/eurj.1099886
AMA	erdoğdu b,UTKAN G The relationship between body mass index and clinical properties/survival in patients with breast cancer. The European Research Journal. 2023; 9(4): 770 - 778. 10.18621/eurj.1099886
Vancouver	erdoğdu b,UTKAN G The relationship between body mass index and clinical properties/survival in patients with breast cancer. The European Research Journal. 2023; 9(4): 770 - 778. 10.18621/eurj.1099886
IEEE	erdoğdu b,UTKAN G "The relationship between body mass index and clinical properties/survival in patients with breast cancer." The European Research Journal, 9, ss.770 - 778, 2023. 10.18621/eurj.1099886
ISNAD	erdoğdu, batuhan - UTKAN, GÜNGOR. "The relationship between body mass index and clinical properties/survival in patients with breast cancer". The European Research Journal 9/4 (2023), 770-778. https://doi.org/10.18621/eurj.1099886