Hypochlorous Acid: A Novel Agent Against Echinococcus granulosus Protoscoleces
Yıl: 2023 Cilt: 5 Sayı: 2 Sayfa Aralığı: 158 - 164 Metin Dili: İngilizce DOI: 10.36519/idcm.2023.238 İndeks Tarihi: 05-07-2023
Hypochlorous Acid: A Novel Agent Against Echinococcus granulosus Protoscoleces
Öz: Objective: We aimed to determine the scolicidal effect of hypochlorous acid and its efficien- cy at different concentrations. Materials and Methods: We tested the effectiveness of hypochlorous acid in-vitro on sterile gauze at different concentrations in test tubes. In addition, we compared its effectiveness with the scolicidal activity of other agents, povidone-iodine 10% and chlorhexidine-gluconate 0.04%. Results: Hypochlorous acid was 100% effective in 5 minutes at 1/1 (200 ppm/mL), 1/10 (20 ppm/mL), and 1/100 (2 ppm/mL) concentrations and in 10 minutes at 1/1000 (0.2 ppm/ mL) concentration. Povidone-iodine 10%, and chlorhexidine-gluconate 0.04% were studied undiluted and were effective at all study times. Hypochlorous acid maintained the same scolicidal activity on gauze at all study times at the described dilutions. Conclusion: Hypochlorous acid is an effective scolicidal agent in 5 minutes at even 1/100 concentrations. In addition, it maintains the same scolicidal activity on gauze used in sur- gery to wall the surgical site.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
- 1 Bosco A, Alves LC, Cociancic P, Amadesi A, Pepe P, Morgoglione ME, et al. Epidemiology and spatial distribution of Echinococcus granulosus in sheep and goats slaughtered in a hyperendemic European Mediterranean area. Parasit Vectors. 2021;14(1):421. [CrossRef]
- 2 Sharafi SM, Sefiddashti RR, Sanei B, Yousefi M, Darani HY. Scolicidal agents for protoscolices of Echinococcus granulosus hydatid cyst: Review of literature. J Res Med Sci. 2017;22:92. [CrossRef]
- 3 Kismet K, Kilicoglu B, Koru O, Tanyuksel M, Oruc MT, Sorkun K, et al. Evaluation on scolicidal efficacy of propolis. Eur Surg Res. 2006;38(5):476-81. [CrossRef]
- 4 Aydin I, Teksoz S, Aytac E, Polat E, Ramazanoglu R, Ozcan M. Scolicidal activity of taurolidine for the treatment of hydatid disease. Bratisl Lek Listy. 2012;113(11):648-51. [CrossRef]
- 5 Kayaalp C. Hydatid disease of the liver. J Gastroenterol Hepa- tol. 2005;20(3):331. [CrossRef]
- 6 Çelik T, Önderci M, Pehlivan M, Yumrutaş Ö, Üçkardeş F. In vitro scolicidal effects of Sideritis perfoliata extract against Echinococ- cus granulosus. Int J Clin Pract. 2021;75(10):e14498. [CrossRef]
- 7 Besim H, Karayalçin K, Hamamci O, Güngör C, Korkmaz A. Scol- icidal agents in hydatid cyst surgery. HPB Surg. 1998;10(6):347- 51. [CrossRef]
- 8 Caglar R, Yuzbasioglu MF, Bulbuloglu E, Gul M, Ezberci F, Kale IT. In vitro effectiveness of different chemical agents on scol- ices of hydatid cyst. J Invest Surg. 2008;21(2):71-5. [CrossRef]
- 9 Yan P, Daliri EB, Oh DH. New clinical applications of electro- lyzed water: A review. Microorganisms. 2021;9(1):136. [CrossRef]
- 10 Castillo DM, Castillo Y, Delgadillo NA, Neuta Y, Jola J, Calderón JL, et al. Viability and effects on bacterial proteins by oral rins- es with hypochlorous acid as active ingredient. Braz Dent J. 2015;26(5):519-24. [CrossRef]
- 11 Yildiz I, Yilmaz O, Tileklioglu E, Sakarya S, Ertabaklar H. Sta- bilised hypochlorous acid: a new therapeutic strategy against dangerous parasitic eye infection agent Acanthamoeba spp. J Environ Prot Ecol. 2018;19(3):1397-404.
- 12 Puryan K, Karadayi K, Topcu O, Canbay E, Sumer Z, Turan M, et al. Chlorhexidine gluconate: an ideal scolicidal agent in the treatment of intraperitoneal hydatidosis? World J Surg. 2005;29(2):227-30. [CrossRef] S.A., U.D.; Literature Review – O.N.G.; Writer – O.N.G., K.Ç., Ş.T., S.A., U.D.; Critical Reviews – O.N.G., K.Ç., Ş.T., S.A., U.D. Conflict of Interest: The authors declare no conflict of interest. Financial Disclosure: The authors declared that this study has received no financial support. Funding: This work was financially supported by a grant from Çanakkale Onsekiz Mart University, the Scientific Research Coordination Unit (Project number: 3692)
- 13 Mohammadnejad F, Ghaffarifar F, Dalimi A, Hassan ZM. In vi- tro effects of artemether, artemisinine, albendazole, and their combinations on Echinococcus granolosus protoscoleces. Jundis- hapur J Nat Pharm Prod. 2016;11(1):e30565. [CrossRef]
- 14 Goksoy E, Saklak M, Saribeyoglu K, Schumpelick V. [Surgery for Echinococcus cysts in the liver]. Chirurg. 2008;79(8):729-37. German. [CrossRef]
- 15 Rouhani S, Salehi N, Kamalinejad M, Zayeri F. Efficacy of Ber- beris vulgaris aqueous extract on viability of Echinococcus granu- losus protoscolices. J Invest Surg. 2013;26(6):347-51. [CrossRef]
- 16 Mahmoudvand H, Asadi A, Harandi MF, Sharififar F, Jahan- bakhsh S, Dezaki ES. In vitro lethal effects of various extracts of Nigella sativa seed on hydatid cyst protoscoleces. Iran J Basic Med Sci. 2014;17(12):1001-6.
- 17 Zellama D, Ayed S, Azzabi A, Mrabet S, Sahtout W, Fradi A, et al. Acute kidney injury due to povidone-iodine. Saudi J Kidney Dis Transpl. 2020;31(5):1125-8. [CrossRef]
- 18 Song HL, Zhang DM, Wen H, Wang M, Zhao N, Gao YH, et al. Peritoneal lavage with povidone-iodine solution in colorectal cancer-induced rats. J Surg Res. 2018;228:93-9. [CrossRef]
- 19 Edmiston CE Jr, Spencer M, Leaper D. Antiseptic irrigation as an effective interventional strategy for reducing the risk of surgical site infections. Surg Infect (Larchmt). 2018;19(8):774- 80. [CrossRef]
- 20 Wen H, Vuitton L, Tuxun T, Li J, Vuitton DA, Zhang W, et al. Echinococcosis: Advances in the 21st century. Clin Microbiol Rev. 2019;32(2):e00075-18. [CrossRef]
- 21 Topcu O, Kuzu I, Karayalcin K. Effects of peritoneal lavage with scolicidal agents on survival and adhesion formation in rats. World J Surg. 2006;30(1):127-33. [CrossRef]
- 22 Rose MA, Garcez T, Savic S, Garvey LH. Chlorhexidine allergy in the perioperative setting: a narrative review. Br J Anaesth. 2019;123(1):e95-e103. [CrossRef]
- 23 Goto K, Kuwayama E, Nozu R, Ueno M, Hayashimoto N. Ef- fect of hypochlorous acid solution on the eradication and prevention of Pseudomonas aeruginosa infection, serum bio- chemical variables, and cecum microbiota in rats. Exp Anim. 2015;64(2):191-7. [CrossRef]
- 24 Sakurai Y, Ogoshi K, Okubo T, Kaku M, Kobayashi I. Strongly acidic electrolyzed water: Valuable disinfectant of endoscopes. Digestive Endoscopy. 2002;14(2):61-6.
- 25 Beltrán-Partida E, Valdez-Salas B, Escamilla A, Curiel M, Val- dez-Salas E, Nedev N, et al. Disinfection of titanium dioxide nanotubes using super-oxidized water decrease bacterial via- bility without disrupting osteoblast behavior. Mater Sci Eng C Mater Biol Appl. 2016;60:239-45. [CrossRef]
- 26 Pullar JM, Vissers MC, Winterbourn CC. Living with a killer: the effects of hypochlorous acid on mammalian cells. IUBMB Life. 2000;50(4-5):259-66. [CrossRef]
- 27 Eryilmaz M, Palabiyik IM. Hypochlorous acid-analyti- cal methods and antimicrobial activity. Trop J Pharm Res. 2013;12(1):123-6. [CrossRef]
- 28 Sakarya S, Gunay N, Karakulak M, Ozturk B, Ertugrul B. Hypo- chlorous acid: an ideal wound care agent with powerful mi- crobicidal, antibiofilm, and wound healing potency. Wounds. 2014;26(12):342-50.
- 29 Kramer A, Dissemond J, Kim S, Willy C, Mayer D, Papke R, et al. Consensus on wound antisepsis: Update 2018. Skin Pharmacol Physiol. 2018;31(1):28-58. [CrossRef]
- 30 Armstrong DG, Bohn G, Glat P, Kavros SJ, Kirsner R, Snyder R, et al. Expert recommendations for the use of hypochlorous solu- tion: Science and clinical application. Ostomy Wound Manage. 2015;61(5):S2-S19.
| APA | GÖKÇE O, Çetin K, tas s, ALKAN S, Dinç U (2023). Hypochlorous Acid: A Novel Agent Against Echinococcus granulosus Protoscoleces. , 158 - 164. 10.36519/idcm.2023.238 |
| Chicago | GÖKÇE Oruç Numan,Çetin Kenan,tas sukru,ALKAN Sevil,Dinç Uğur Hypochlorous Acid: A Novel Agent Against Echinococcus granulosus Protoscoleces. (2023): 158 - 164. 10.36519/idcm.2023.238 |
| MLA | GÖKÇE Oruç Numan,Çetin Kenan,tas sukru,ALKAN Sevil,Dinç Uğur Hypochlorous Acid: A Novel Agent Against Echinococcus granulosus Protoscoleces. , 2023, ss.158 - 164. 10.36519/idcm.2023.238 |
| AMA | GÖKÇE O,Çetin K,tas s,ALKAN S,Dinç U Hypochlorous Acid: A Novel Agent Against Echinococcus granulosus Protoscoleces. . 2023; 158 - 164. 10.36519/idcm.2023.238 |
| Vancouver | GÖKÇE O,Çetin K,tas s,ALKAN S,Dinç U Hypochlorous Acid: A Novel Agent Against Echinococcus granulosus Protoscoleces. . 2023; 158 - 164. 10.36519/idcm.2023.238 |
| IEEE | GÖKÇE O,Çetin K,tas s,ALKAN S,Dinç U "Hypochlorous Acid: A Novel Agent Against Echinococcus granulosus Protoscoleces." , ss.158 - 164, 2023. 10.36519/idcm.2023.238 |
| ISNAD | GÖKÇE, Oruç Numan vd. "Hypochlorous Acid: A Novel Agent Against Echinococcus granulosus Protoscoleces". (2023), 158-164. https://doi.org/10.36519/idcm.2023.238 |
| APA | GÖKÇE O, Çetin K, tas s, ALKAN S, Dinç U (2023). Hypochlorous Acid: A Novel Agent Against Echinococcus granulosus Protoscoleces. Infectious diseases and clinical microbiology (Online), 5(2), 158 - 164. 10.36519/idcm.2023.238 |
| Chicago | GÖKÇE Oruç Numan,Çetin Kenan,tas sukru,ALKAN Sevil,Dinç Uğur Hypochlorous Acid: A Novel Agent Against Echinococcus granulosus Protoscoleces. Infectious diseases and clinical microbiology (Online) 5, no.2 (2023): 158 - 164. 10.36519/idcm.2023.238 |
| MLA | GÖKÇE Oruç Numan,Çetin Kenan,tas sukru,ALKAN Sevil,Dinç Uğur Hypochlorous Acid: A Novel Agent Against Echinococcus granulosus Protoscoleces. Infectious diseases and clinical microbiology (Online), vol.5, no.2, 2023, ss.158 - 164. 10.36519/idcm.2023.238 |
| AMA | GÖKÇE O,Çetin K,tas s,ALKAN S,Dinç U Hypochlorous Acid: A Novel Agent Against Echinococcus granulosus Protoscoleces. Infectious diseases and clinical microbiology (Online). 2023; 5(2): 158 - 164. 10.36519/idcm.2023.238 |
| Vancouver | GÖKÇE O,Çetin K,tas s,ALKAN S,Dinç U Hypochlorous Acid: A Novel Agent Against Echinococcus granulosus Protoscoleces. Infectious diseases and clinical microbiology (Online). 2023; 5(2): 158 - 164. 10.36519/idcm.2023.238 |
| IEEE | GÖKÇE O,Çetin K,tas s,ALKAN S,Dinç U "Hypochlorous Acid: A Novel Agent Against Echinococcus granulosus Protoscoleces." Infectious diseases and clinical microbiology (Online), 5, ss.158 - 164, 2023. 10.36519/idcm.2023.238 |
| ISNAD | GÖKÇE, Oruç Numan vd. "Hypochlorous Acid: A Novel Agent Against Echinococcus granulosus Protoscoleces". Infectious diseases and clinical microbiology (Online) 5/2 (2023), 158-164. https://doi.org/10.36519/idcm.2023.238 |
