TY  - JOUR
TI  - Association of Leucocyte Telomere Length with Nasopharyngeal Carcinoma Risk and Prognosis
AB  - Objectives: Cancer development and/or progression can be imputed to telomere shortening or lengthening. The cur- rent research was planned to assess the relation between leucocyte telomere length (LTL) and nasopharyngeal carci- noma (NPC) development, and to evaluate the association between this biomarker and patients' clinical outcomes, mainly response to chemo-radiotherapy, survival and EBV-DNA load. Methods: Leucocyte telomere length was measured using a singleplex quantitative polymerase chain reaction (qPCR) method in 104 NPC patients and 52 healthy controls. The association between LTL and NPC development was assessed using a Khi-deux test. Odds ratios (ORs) and 95% confidence intervals (CI) were calculated by conditional logistic re- gression to evaluate the relationship LTL and patient’s characteristics. The correlation between LTL and 4-years patient’s survival outcomes was assessed by Kaplan–Meier and Cox-regression analyses. Results: Data analysis revealed a significant association between LTL and risk of NPC development (p<0.0001). LTL was also significantly associated with gender (p=0.003), cigarette smoking (p=0.02) and pre-EBV-DNA load (p=0.017) in NPC. However, no significant association was obtained between LTL and age, alcohol consumption, TNM classification, disease stage, response to chemo-radiotherapy and survival outcomes of NPC patients (p>0.05). Conclusion: The study finding highlighted the close association between LTL and NPC development and showed a sig- nificant association with gender, cigarette smoking and pre-EBV-DNA load, suggesting that LTL could be a promising biomarker for better management of NPC in Morocco. Nevertheless, more studies are needed to highlight the value of LTL as a biomarker for the prediction of the response to treatment and prognosis of NPC.
AU  - El Mzibri, Mohammed
AU  - chaoui, imane
AU  - ALAMI, Imane El
AU  - Benchakroun, Nadia
AU  - BENIDER, Abdellatif
AU  - amina, gihbid
AU  - Charoute, Hicham
AU  - TAWFIQ, Nezha
AU  - Benani, abdelouaheb
AU  - BRAHIM, Selma Mohamed
AU  - AZZOUZI, Meryem El
AU  - BELGHMI, Khalid
AU  - Khyatti, Meriem
DO  - 10.14744/ejmo.2023.19019
PY  - 2023
JO  - Eurasian Journal of Medicine and Oncology
VL  - 7
IS  - 2
SN  - 2587-2400
SP  - 135
EP  - 142
DB  - TRDizin
UR  - http://search/yayin/detay/1184002
ER  -