Prognostic Impact of Coexpressed CXCL12 and CD44v5 on Human Cervical Cancer After Radiotherapy: Stem-Like Hallmark and Radioresistance

FU, Zhichao; LI, Guo; ZHONG, Nanbao; WANG, Fengmei

doi:10.14744/ejmo.2023.20874

Prognostic Impact of Coexpressed CXCL12 and CD44v5 on Human Cervical Cancer After Radiotherapy: Stem-Like Hallmark and Radioresistance

Zhichao FU, (Department of Radiotherapy, Fuzong Clinical Medical College of Fujian Medical University, Fuzhou, Fujian, China)

Guo LI, (Department of Radiotherapy, Fuzong Clinical Medical College of Fujian Medical University, Fuzhou, Fujian, China)

Nanbao ZHONG, (Department of Radiotherapy, Fuzong Clinical Medical College of Fujian Medical University, Fuzhou, Fujian, China)

Fengmei WANG (Department of Obstetrics and Gynecology, Fuzong Clinical Medical College of Fujian Medical University, Fuzhou,Fujian, China)

Eurasian Journal of Medicine and Oncology

4 0

Yıl: 2023 Cilt: 7 Sayı: 2 Sayfa Aralığı: 189 - 196 Metin Dili: İngilizce DOI: 10.14744/ejmo.2023.20874 İndeks Tarihi: 05-07-2023

Prognostic Impact of Coexpressed CXCL12 and CD44v5 on Human Cervical Cancer After Radiotherapy: Stem-Like Hallmark and Radioresistance

Öz:

Objectives: The aim of this study is to investigate the prognostic impact of CXCL12 and CD44v5 on patients with ad- vanced cervical cancer. Methods: Paraffin specimens from 130 advanced cervix cancer before radiotherapy were examined using immunohis- tochemistry to test the expressions of CXCL12 and CD44v5. The correlations between the expressions of CXCL12 and CD44v5 and the five-year survival rate were analyzed. The expression changes of CXCL12 and CD44v5 in residual cancer tissues after a total radiotherapy dose of 50 Gy were tested by Real-Time PCR. Results: In the 130 patients, a significant correlation was found between CXCL12 and CD44v5 (P=0.028). The coexpres- sion occurred in 34 patients with lower five-year survival rate of 22.9%.There was no correlation between the expression of CXCL12 and CD44v5 and age, tumor stage, size, pelvic lymph node involvement and therapeutic schedule. Log-rank and multi-factor survivals analysis showed that tumor stage, lymph node involvement, CXCL12 expression, CD44v5 expression, CXCL12 and CD44v5 co-expression were independent prognostic factors. The expressions of CXCL12 and CD44 were significant elevated in residual tumor tissues, when compared to pre-radiotherapy, (p<0.05). Conclusion: A significant positive correlation occurred between the expression of CXCL12 and CD44v5. The coexpres- sion might be informative regarding poor prognosis in patients with radical radiotherapy.

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APA	FU Z, LI G, ZHONG N, WANG F (2023). Prognostic Impact of Coexpressed CXCL12 and CD44v5 on Human Cervical Cancer After Radiotherapy: Stem-Like Hallmark and Radioresistance. , 189 - 196. 10.14744/ejmo.2023.20874
Chicago	FU Zhichao,LI Guo,ZHONG Nanbao,WANG Fengmei Prognostic Impact of Coexpressed CXCL12 and CD44v5 on Human Cervical Cancer After Radiotherapy: Stem-Like Hallmark and Radioresistance. (2023): 189 - 196. 10.14744/ejmo.2023.20874
MLA	FU Zhichao,LI Guo,ZHONG Nanbao,WANG Fengmei Prognostic Impact of Coexpressed CXCL12 and CD44v5 on Human Cervical Cancer After Radiotherapy: Stem-Like Hallmark and Radioresistance. , 2023, ss.189 - 196. 10.14744/ejmo.2023.20874
AMA	FU Z,LI G,ZHONG N,WANG F Prognostic Impact of Coexpressed CXCL12 and CD44v5 on Human Cervical Cancer After Radiotherapy: Stem-Like Hallmark and Radioresistance. . 2023; 189 - 196. 10.14744/ejmo.2023.20874
Vancouver	FU Z,LI G,ZHONG N,WANG F Prognostic Impact of Coexpressed CXCL12 and CD44v5 on Human Cervical Cancer After Radiotherapy: Stem-Like Hallmark and Radioresistance. . 2023; 189 - 196. 10.14744/ejmo.2023.20874
IEEE	FU Z,LI G,ZHONG N,WANG F "Prognostic Impact of Coexpressed CXCL12 and CD44v5 on Human Cervical Cancer After Radiotherapy: Stem-Like Hallmark and Radioresistance." , ss.189 - 196, 2023. 10.14744/ejmo.2023.20874
ISNAD	FU, Zhichao vd. "Prognostic Impact of Coexpressed CXCL12 and CD44v5 on Human Cervical Cancer After Radiotherapy: Stem-Like Hallmark and Radioresistance". (2023), 189-196. https://doi.org/10.14744/ejmo.2023.20874

APA	FU Z, LI G, ZHONG N, WANG F (2023). Prognostic Impact of Coexpressed CXCL12 and CD44v5 on Human Cervical Cancer After Radiotherapy: Stem-Like Hallmark and Radioresistance. Eurasian Journal of Medicine and Oncology, 7(2), 189 - 196. 10.14744/ejmo.2023.20874
Chicago	FU Zhichao,LI Guo,ZHONG Nanbao,WANG Fengmei Prognostic Impact of Coexpressed CXCL12 and CD44v5 on Human Cervical Cancer After Radiotherapy: Stem-Like Hallmark and Radioresistance. Eurasian Journal of Medicine and Oncology 7, no.2 (2023): 189 - 196. 10.14744/ejmo.2023.20874
MLA	FU Zhichao,LI Guo,ZHONG Nanbao,WANG Fengmei Prognostic Impact of Coexpressed CXCL12 and CD44v5 on Human Cervical Cancer After Radiotherapy: Stem-Like Hallmark and Radioresistance. Eurasian Journal of Medicine and Oncology, vol.7, no.2, 2023, ss.189 - 196. 10.14744/ejmo.2023.20874
AMA	FU Z,LI G,ZHONG N,WANG F Prognostic Impact of Coexpressed CXCL12 and CD44v5 on Human Cervical Cancer After Radiotherapy: Stem-Like Hallmark and Radioresistance. Eurasian Journal of Medicine and Oncology. 2023; 7(2): 189 - 196. 10.14744/ejmo.2023.20874
Vancouver	FU Z,LI G,ZHONG N,WANG F Prognostic Impact of Coexpressed CXCL12 and CD44v5 on Human Cervical Cancer After Radiotherapy: Stem-Like Hallmark and Radioresistance. Eurasian Journal of Medicine and Oncology. 2023; 7(2): 189 - 196. 10.14744/ejmo.2023.20874
IEEE	FU Z,LI G,ZHONG N,WANG F "Prognostic Impact of Coexpressed CXCL12 and CD44v5 on Human Cervical Cancer After Radiotherapy: Stem-Like Hallmark and Radioresistance." Eurasian Journal of Medicine and Oncology, 7, ss.189 - 196, 2023. 10.14744/ejmo.2023.20874
ISNAD	FU, Zhichao vd. "Prognostic Impact of Coexpressed CXCL12 and CD44v5 on Human Cervical Cancer After Radiotherapy: Stem-Like Hallmark and Radioresistance". Eurasian Journal of Medicine and Oncology 7/2 (2023), 189-196. https://doi.org/10.14744/ejmo.2023.20874