TY  - JOUR
TI  - Surgery: The Fundamental Part of Treatment in Elderly Esophageal Squamous Cell Carcinoma Patients
AB  - Objectives: Non-metastatic esophageal squamous cell carcinoma (ESCC) patients are treated with neoadjuvant chemoradiotherapy (CRT) followed by surgery. Older patients may have treatment-related toxicity at higher rates. We presented our experience regarding CRT followed by surgery on survival in older ESCC patients. Methods: Older ESCC patients diagnosed between 2009-2021 were included. Overall survival (OS) estimates were cal- culated by Kaplan-Meier analyses and compared by Log-rank tests. Effects of ECOG performance status and age groups on survival were also presented. Results: A total of 66 older ESCC patients were included. The median duration of follow-up was 62.3 months. The me- dian OS of patients who were treated with surgery was significantly higher than those who were treated with CRT alone (48+, CI 95%: - vs. 14.1 months, CI 95%: 9.3-18.8, respectively, p=0.005). The median OS of patients who underwent sur- gery was significantly higher after adjusting by ECOG performance status and age groups than those who were treated with CRT alone (adjusted p=0.008 for ECOG and adjusted p=0.011 for age groups at diagnosis). Conclusion: Surgery after CRT improves survival in older ESCC patients compared to CRT alone. Therefore, surgery should not be avoided in older patients solely due to patient age.
AU  - Demir, Metin
DO  - 10.14744/ejmi.2023.71229
PY  - 2023
JO  - Eurasian Journal of Medical Investigation
VL  - 7
IS  - 2
SN  - 2602-3164
SP  - 162
EP  - 169
DB  - TRDizin
UR  - http://search/yayin/detay/1184778
ER  -