From past to present, the banking sector provides positive contributions to economic growth by transferring resources from those who have surplus funds to those in need of funds. Although the task of minimizing the negative impact of the epidemic on the economy is given to the banking sector, the banking sector is also adversely affected by the epidemic. For this reason, it is important to determine the impact of the epidemic on the banking sector. The aim of the study is to analyze the effect of the epidemic on the banking sector with statistical methods. In this context, some variables in the 22-month period before the epidemic and the 22-month period during the epidemic were analyzed with the paired t-test. As a result of the study, it was concluded that the loan/deposit ratio, equity and return on assets ratios and net interest margins, which are among the performance indicators of banks, decreased and the epidemic negatively affected the banking sector. In order to prevent the decrease in the performance indicators of the banks and to reduce the intermediation costs, it is necessary to make a regulation regarding the taxes, which is one of the fiscal policy instruments.