COVID-19’da Gözlenen Oral Bulgular: Literatür Derlemesi

OTAN ÖZDEN, Feyza; karaman, emel

doi:10.5505/yeditepe.2023.33716

COVID-19’da Gözlenen Oral Bulgular: Literatür Derlemesi

Feyza OTAN ÖZDEN, (Ondokuz Mayıs Üniversitesi, Diş Hekimliği Fakültesi, Periodontoloji A.D., Samsun, TÜRKİYE)

Emel KARAMAN (Ondokuz Mayıs Üniversitesi, Diş Hekimliği Fakültesi, Restoratif Diş Tedavisi A.D., Samsun, TÜRKİYE)

7tepe Klinik

43 16

Yıl: 2023 Cilt: 19 Sayı: 1 Sayfa Aralığı: 68 - 74 Metin Dili: Türkçe DOI: 10.5505/yeditepe.2023.33716 İndeks Tarihi: 08-07-2023

COVID-19’da Gözlenen Oral Bulgular: Literatür Derlemesi

Öz:

COVID-19 şiddetli akut solunum sendromu koronavirüsü 2 (SARS-CoV-2)'nin neden olduğu bulaşıcı bir enfeksiyon has- talığıdır. Dünya Sağlık Örgütü tarafından pandemik bir hasta- lık olarak ilan edilen COVID-19, kısa sürede tüm dünyada bü- yük bir halk sağlığı sorunu haline gelmiştir. Virüs temel olarak damlacık ve temas yoluyla bulaş göstermektedir. Bu derleme- de, COVID-19 hastalığında görülebilen oral bulgular güncel çalışmalarla değerlendirilmiştir. Sınırlı vaka raporlarında tat kaybı, aft benzeri lezyonlar, oral ülserler, herpetiform ülser- ler, angular cheilitis, nekrotizan gingivitis, eritema multiforme benzeri lezyonlar rapor edilmiştir. COVID-19 ve oral bulguları arasındaki ilişki SARS-CoV-2 nin oral mukoza hücrelerine di- rekt veya indirekt etkisi, fırsatçı enfeksiyonlar, immün sistem yetmezliği ve tedavi amacı ile kullanılan ilaçların yan etkileri ile ilişkilendirilebilmektedir. Oral bulgular COVID-19’un erken dönem teşhisi açısından kri- tiktir. COVID-19 ile ilişkili oral bulgu ve semptomların diş he- kimleri tarafından teşhisi, hastalığın erken tanısının yanı sıra yayılımını da engellemek adına önemlidir.

Anahtar Kelime:

Oral Findings Observed in COVID-19: Literature Review

Öz:

COVID-19 is a contagious infectious disease caused by seve- re acute respiratory syndrome coronavirus 2 (SARS-CoV-2). COVID-19, declared as a pandemic disease by the World He- alth Organization, has become a major public health problem all over the world in a short time. Virus is mainly transmitted by droplets and contact. In this review article, oral findings that can be seen in COVID-19 disease were evaluated with current studies. Taste alteration, aphthous-like lesions, oral ulcers, herpetiform ulcers, angular cheilitis, necrotizing gingivitis, and erythema multiforme-like lesions have been reported in limited case reports. The relationship between COVID-19 and its oral manifestations can be associated with the direct or in- direct effect of SARS-CoV-2 on oral mucosal cells, opportu- nistic infections, immunosupression, and side effects of drugs used for treatment. Oral findings are critical for the early diag- nosis of COVID-19.Diagnosis of the oral signs and symptoms associated with COVID-19 by dentists is important in order to prevent the spread of the disease as well as early diagnosis.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Derleme Erişim Türü: Erişime Açık

KAYNAKLAR 1. Hu B, Guo H, Zhou P, Shi Z-L. Characteristics of SARS CoV-2 and COVID-19. Nature Reviews Microbiology. 2021;19(3):141-54.
2. Capocasale G, Nocini R, Faccioni P, Donadello D, Ber tossi D, Albanese M, et al. How to deal with coronavirus disease 2019: A comprehensive narrative review about oral involvement of the disease. Clinical and Experimental Dental Research. 2021;7(1):101-8.
3. Haque SM, Ashwaq O, Sarief A, Azad John Mohamed AK. A comprehensive review about SARS-CoV-2. Future Virology. 2020;15(9):625-48.
4. Xu H, Zhong L, Deng J, Peng J, Dan H, Zeng X, et al. High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa. International journal of oral science. 2020;12(1):1-5.
5. Xu J, Li Y, Gan F, Du Y, Yao Y. Salivary glands: potential reservoirs for COVID-19 asymptomatic infection. Journal of dental research. 2020;99(8):989-.
6. Phelan AL, Katz R, Gostin LO. The novel coronavirus originating in Wuhan, China: challenges for global health governance. Jama. 2020;323(8):709-10.
7. Tang K, Wang Y, Zhang H, Zheng Q, Fang R, Sun Q. Cutaneous manifestations of the Coronavirus Disease 2019 (COVID 19): A brief review. Dermatologic therapy. 2020;33(4):e13528.
8. Rodríguez MD, Romera AJ, Villarroel M. Oral manifesta tions associated with COVID 19. Oral diseases. 2020.
9. Fantozzi PJ, Pampena E, Di Vanna D, Pellegrino E, Corbi D, Mammucari S, et al. Xerostomia, gustatory and olfac tory dysfunctions in patients with COVID-19. American journal of otolaryngology. 2020;41(6):102721.
10. Brandão TB, Gueiros LA, Melo TS, Prado-Ribeiro AC, Nesrallah ACFA, Prado GVB, et al. Oral lesions in patients with SARS-CoV-2 infection: could the oral cavity be a tar get organ? Oral surgery, oral medicine, oral pathology and oral radiology. 2021;131(2):e45-e51.
11. Glavina A, Biočina Lukenda D, Mravak Stipetić M, Markeljević J. Oral symptoms and lesions in SARS CoV 2 positive patient. Oral Diseases. 2020.
12. Carreras Presas CM, Sánchez JA, López Sánchez AF, Jané Salas E, Pérez MLS. Oral vesiculobullous lesions as sociated with SARS CoV 2 infection. Oral diseases. 2020.
13. Ansari R, Gheitani M, Heidari F. Oral cavity lesions as a manifestation of the novel virus (COVID-19): a letter-to-edi tor. Oral Diseases. 2020.
14. Soares CD, de Carvalho RA, de Carvalho KA, de Car valho MGF, de Almeida OP. Letter to Editor: Oral lesions in a patient with Covid-19. Medicina oral, patologia oral y cirugia bucal. 2020;25(4):e563.
15. Riad A, Klugar M, Krsek M. COVID 19 related oral ma nifestations, early disease features? Oral Diseases. 2020.
16. Patel J, Woolley J. Necrotizing periodontal disease: Oral manifestation of COVID 19. Oral diseases. 2020.
17. Jimenez Cauhe J, Ortega Quijano D, Carretero Barrio I, Suarez Valle A, Saceda Corralo D, Del Real CMG, et al. Erythema multiforme like eruption in patients with CO VID 19 infection: clinical and histological findings. Clini cal and experimental dermatology. 2020.
18. Amorim dos Santos J, Normando A, Carvalho da Silva R, Acevedo A, De Luca Canto G, Sugaya N, et al. Oral ma nifestations in patients with COVID-19: a living systematic review. Journal of dental research. 2021;100(2):141-54.
19. Halboub E, Al-Maweri SA, Alanazi RH, Qaid NM, Ab dulrab S. Orofacial manifestations of COVID-19: a brief review of the published literature. Brazilian oral research. 2020;34.
20. Cox MJ, Loman N, Bogaert D, O'Grady J. Co-infecti ons: potentially lethal and unexplored in COVID-19. The Lancet Microbe. 2020;1(1):e11.
21. Dziedzic A, Wojtyczka R. The impact of coronavirus infectious disease 19 (COVID 19) on oral health. Oral dise ases. 2021;27:703-6.
22. Borges do Nascimento IJ, Cacic N, Abdulazeem HM, von Groote TC, Jayarajah U, Weerasekara I, et al. Novel coronavirus infection (COVID-19) in humans: a scoping review and meta-analysis. Journal of clinical medicine. 2020;9(4):941.
23. Yang Y, Zhou Y, Liu X, Tan J. Health services provi sion of 48 public tertiary dental hospitals during the CO VID-19 epidemic in China. Clinical oral investigations. 2020;24(5):1861-4.
24. Bénézit F, Le Turnier P, Declerck C, Paillé C, Revest M, Dubée V, et al. Utility of hyposmia and hypogeusia for the diagnosis of COVID-19. The Lancet Infectious Diseases. 2020;20(9):1014-5.
25. Keyhan SO, Fallahi HR, Cheshmi B. Dysosmia and dy sgeusia due to the 2019 Novel Coronavirus; a hypothesis that needs further investigation. SpringerOpen; 2020. p. 1-2.
26. Paderno A, Schreiber A, Grammatica A, Raffetti E, To masoni M, Gualtieri T, et al., editors. Smell and taste alte rations in Covid 19: a cross sectional analysis of different cohorts. International forum of allergy & rhinology; 2020: Wiley Online Library.
27. Hjelmesæth J, Skaare D. Loss of smell or taste as the only symptom of COVID-19. Tidsskrift for Den norske le geforening. 2020.
28. Vargas-Gandica J, Winter D, Schnippe R, Rodrigu ez-Morales AG, Mondragon J, Escalera-Antezana JP, et al. Ageusia and anosmia, a common sign of COVID-19? A case series from four countries. Journal of neurovirology. 2020;26(5):785-9.
29. Aziz M, Perisetti A, Lee-Smith WM, Gajendran M, Ban sal P, Goyal H. Taste changes (Dysgeusia) in COVID-19: a systematic review and meta-analysis. Gastroenterology. 2020;159(3):1132.
30. Biadsee A, Biadsee A, Kassem F, Dagan O, Masarwa S, Ormianer Z. <? covid19?> Olfactory and Oral Manifes tations of COVID-19: Sex-Related Symptoms—A Potential Pathway to Early Diagnosis. Otolaryngology–Head and Neck Surgery. 2020;163(4):722-8.
31. Yan CH, Faraji F, Prajapati DP, Boone CE, DeConde AS, editors. Association of chemosensory dysfunction and Covid 19 in patients presenting with influenza like symp toms. International forum of allergy & rhinology; 2020: Wi ley Online Library.
32. Bodnia NC, Katzenstein TL. Acute loss of smell and taste among patients with symptoms compatible with CO VID 19. Dan Med J. 2020;67(9):A05200370.
33. Agyeman AA, Chin KL, Landersdorfer CB, Liew D, Ofori-Asenso R, editors. Smell and taste dysfunction in patients with COVID-19: a systematic review and meta-a nalysis. Mayo Clinic Proceedings; 2020: Elsevier.
34. Knight A. The differential diagnosis of rhinorrhea. Jour nal of allergy and clinical immunology. 1995;95(5):1080- 3.
35. Tomo S, Miyahara GI, Simonato LE. Oral mucositis in a SARS CoV 2 infected patient: secondary or truly associa ted condition? Oral diseases. 2020.
36. Tay MZ, Poh CM, Rénia L, MacAry PA, Ng LF. The tri nity of COVID-19: immunity, inflammation and interventi on. Nature Reviews Immunology. 2020;20(6):363-74.
37. Sakaguchi W, Kubota N, Shimizu T, Saruta J, Fuchida S, Kawata A, et al. Existence of SARS-CoV-2 entry mole cules in the oral cavity. International journal of molecular sciences. 2020;21(17):6000.
38. Dos Santos JA, Normando AGC, da Silva RLC, De Pa ula RM, Cembranel AC, Santos-Silva AR, et al. Oral muco sal lesions in a COVID-19 patient: New signs or secondary manifestations? International Journal of Infectious Disea ses. 2020;97:326-8.
39. Petrescu N, Lucaciu O, Roman A. Oral mucosa lesions in COVID 19. Oral Diseases. 2020.
40. de Sousa FACG, Paradella TC. Considerations on oral manifestations of COVID 19. Journal of Medical Virology. 2020.
41. Chaux-Bodard A-G, Deneuve S, Desoutter A. Oral ma nifestation of Covid-19 as an inaugural symptom? Journal of Oral Medicine and Oral Surgery. 2020;26(2):18.
42. Corchuelo J, Ulloa FC. Oral manifestations in a patient with a history of asymptomatic COVID-19: Case report. In ternational journal of infectious diseases. 2020;100:154-7.
43. Mariz B, Brandão T, Ribeiro A, Lopes M, Santos-Silva A. New insights for the pathogenesis of COVID-19-related dysgeusia. Journal of dental research. 2020;99(10):1206-.
44. Riad A, Kassem I, Stanek J, Badrah M, Klugarova J, Klugar M. Aphthous stomatitis in COVID 19 patients: Case series and literature review. Dermatologic Therapy. 2021;34(1).
45. Malih N, Hajinasrollah G, Zare M, Taheri M. Unexpected presentation of COVID-19 in a 38-year-old male patient: a case report. Case Reports in Dermatology. 2020;12(2):124-31.
46. Dominguez Santas M, Diaz Guimaraens B, Fernan dez Nieto D, Jimenez Cauhe J, Ortega Quijano D, Sua rez Valle A. Minor aphthae associated with SARS CoV 2 infection. International Journal of Dermatology. 2020.
47. Aghazadeh N, Homayouni M, Sartori-Valinotti JC. Oral vesicles and acral erythema: report of a cutaneous mani festation of COVID-19. Int J Dermatol. 2020:1153-4.
48. Kämmerer T, Walch J, Flaig M, French L. COVID 19 associated herpetic gingivostomatitis. Clinical and Expe rimental Dermatology. 2021;46(1):174-6.
49. Kahraman FC, Çaşkurlu H. Mucosal involvement in a COVID 19 positive patient: a case report. Dermatologic therapy. 2020.
50. Fathi Y, Hoseini EG, Mottaghi R. Erythema multiform-li ke lesions in a patient infected with SARS-CoV-2: a case report. Future Virology. 2021;16(3):157-60.
51. Jones VG, Mills M, Suarez D, Hogan CA, Yeh D, Segal JB, et al. COVID-19 and Kawasaki disease: novel virus and novel case. Hospital pediatrics. 2020;10(6):537-40.
52. Labé P, Ly A, Sin C, Nasser M, Chapelon Fromont E, Saïd PB, et al. Erythema multiforme and Kawasaki disease associated with COVID 19 infection in children. Journal of the European Academy of Dermatology and Venereo logy. 2020.
53. Verdoni L, Mazza A, Gervasoni A, Martelli L, Rugge ri M, Ciuffreda M, et al. An outbreak of severe Kawasa ki-like disease at the Italian epicentre of the SARS-CoV-2 epidemic: an observational cohort study. The Lancet. 2020;395(10239):1771-8.
54. Fernandes Matuck B, Dolhnikoff M, Maia GV, Isaac Sendyk D, Zarpellon A, Costa Gomes S, et al. Periodontal tissues are targets for Sars-Cov-2: a post-mortem study. Journal of Oral Microbiology. 2021;13(1):1848135.
55. Botros N, Iyer P, Ojcius DM. Is there an association between oral health and severity of COVID-19 complicati ons? biomedical journal. 2020;43(4):325-7.
56. Kara C, Çelen K, Dede FÖ, Gökmenoğlu C, Kara NB. Is periodontal disease a risk factor for developing severe Covid-19 infection? The potential role of Galectin-3. Expe rimental Biology and Medicine. 2020;245(16):1425-7.
57. Badran Z, Gaudin A, Struillou X, Amador G, Soueidan A. Periodontal pockets: A potential reservoir for SARS CoV-2? Medical Hypotheses. 2020;143:109907.
58. Müller F. Oral hygiene reduces the mortality from aspi ration pneumonia in frail elders. Journal of dental resear ch. 2015;94(3_suppl):14S-6S.
59. Eccles R. Understanding the symptoms of the com mon cold and influenza. The Lancet infectious diseases. 2005;5(11):718-25.
60. Whittet H. Infraorbital nerve dehiscence: the anatomic cause of maxillary sinus “vacuum headache”? Otolaryn gology—Head and Neck Surgery. 1992;107(1):21-8.
61. Homma Y, Watanabe M, Inoue K, Moritaka T. Corona virus disease-19 pneumonia with facial nerve palsy and ol factory disturbance. Internal Medicine. 2020;59(14):1773- 5.
62. Riad A, Kassem I, Hockova B, Badrah M, Klugar M. Tongue ulcers associated with SARS-CoV-2 infection: A case series. Oral diseases. 2020.

APA	OTAN ÖZDEN F, karaman e (2023). COVID-19’da Gözlenen Oral Bulgular: Literatür Derlemesi. , 68 - 74. 10.5505/yeditepe.2023.33716
Chicago	OTAN ÖZDEN Feyza,karaman emel COVID-19’da Gözlenen Oral Bulgular: Literatür Derlemesi. (2023): 68 - 74. 10.5505/yeditepe.2023.33716
MLA	OTAN ÖZDEN Feyza,karaman emel COVID-19’da Gözlenen Oral Bulgular: Literatür Derlemesi. , 2023, ss.68 - 74. 10.5505/yeditepe.2023.33716
AMA	OTAN ÖZDEN F,karaman e COVID-19’da Gözlenen Oral Bulgular: Literatür Derlemesi. . 2023; 68 - 74. 10.5505/yeditepe.2023.33716
Vancouver	OTAN ÖZDEN F,karaman e COVID-19’da Gözlenen Oral Bulgular: Literatür Derlemesi. . 2023; 68 - 74. 10.5505/yeditepe.2023.33716
IEEE	OTAN ÖZDEN F,karaman e "COVID-19’da Gözlenen Oral Bulgular: Literatür Derlemesi." , ss.68 - 74, 2023. 10.5505/yeditepe.2023.33716
ISNAD	OTAN ÖZDEN, Feyza - karaman, emel. "COVID-19’da Gözlenen Oral Bulgular: Literatür Derlemesi". (2023), 68-74. https://doi.org/10.5505/yeditepe.2023.33716

APA	OTAN ÖZDEN F, karaman e (2023). COVID-19’da Gözlenen Oral Bulgular: Literatür Derlemesi. 7tepe Klinik, 19(1), 68 - 74. 10.5505/yeditepe.2023.33716
Chicago	OTAN ÖZDEN Feyza,karaman emel COVID-19’da Gözlenen Oral Bulgular: Literatür Derlemesi. 7tepe Klinik 19, no.1 (2023): 68 - 74. 10.5505/yeditepe.2023.33716
MLA	OTAN ÖZDEN Feyza,karaman emel COVID-19’da Gözlenen Oral Bulgular: Literatür Derlemesi. 7tepe Klinik, vol.19, no.1, 2023, ss.68 - 74. 10.5505/yeditepe.2023.33716
AMA	OTAN ÖZDEN F,karaman e COVID-19’da Gözlenen Oral Bulgular: Literatür Derlemesi. 7tepe Klinik. 2023; 19(1): 68 - 74. 10.5505/yeditepe.2023.33716
Vancouver	OTAN ÖZDEN F,karaman e COVID-19’da Gözlenen Oral Bulgular: Literatür Derlemesi. 7tepe Klinik. 2023; 19(1): 68 - 74. 10.5505/yeditepe.2023.33716
IEEE	OTAN ÖZDEN F,karaman e "COVID-19’da Gözlenen Oral Bulgular: Literatür Derlemesi." 7tepe Klinik, 19, ss.68 - 74, 2023. 10.5505/yeditepe.2023.33716
ISNAD	OTAN ÖZDEN, Feyza - karaman, emel. "COVID-19’da Gözlenen Oral Bulgular: Literatür Derlemesi". 7tepe Klinik 19/1 (2023), 68-74. https://doi.org/10.5505/yeditepe.2023.33716