GENETIC POLYMORPHISM OF APE1 ASP148GLU IS NOT ASSOCIATED WITH BLADDER CANCER RISK IN A TURKISH POPULATION

Kılınç, Serhat; Erdem, Selcuk; Değirmenci, Enes; Sanli, Oner; KUCUKGERGIN, CANAN; RENDI, TAGHI AHMADI; Dogru-Abbasoglu, Semra

doi:10.26650/JARHS2023-1273011

GENETIC POLYMORPHISM OF APE1 ASP148GLU IS NOT ASSOCIATED WITH BLADDER CANCER RISK IN A TURKISH POPULATION

TAGHI AHMADI RENDI, (İstanbul Üniversitesi, Sağlık Bilimleri Enstitüsü, Biyokimya Anabilim Dalı, İstanbul, Türkiye)

Serhat KILINÇ, (İstanbul Üniversitesi, Sağlık Bilimleri Enstitüsü, Biyokimya Anabilim Dalı, İstanbul, Türkiye)

Selçuk ERDEM, (İstanbul Üniversitesi, Sağlık Bilimleri Enstitüsü, Biyokimya Anabilim Dalı, İstanbul, Türkiye)

Enes DEĞİRMENCİ, (İstanbul Üniversitesi, Sağlık Bilimleri Enstitüsü, Biyokimya Anabilim Dalı, İstanbul, Türkiye)

Öner ŞANLI, (İstanbul Üniversitesi, Sağlık Bilimleri Enstitüsü, Biyokimya Anabilim Dalı, İstanbul, Türkiye)

Canan KÜÇÜKGERGİN, (İstanbul Üniversitesi, Sağlık Bilimleri Enstitüsü, Biyokimya Anabilim Dalı, İstanbul, Türkiye)

Semra DOĞRU ABBASOĞLU (İstanbul Üniversitesi, Sağlık Bilimleri Enstitüsü, Biyokimya Anabilim Dalı, İstanbul, Türkiye)

Sabiad

12 4

Yıl: 2023 Cilt: 6 Sayı: 2 Sayfa Aralığı: 117 - 121 Metin Dili: İngilizce DOI: 10.26650/JARHS2023-1273011 İndeks Tarihi: 08-07-2023

GENETIC POLYMORPHISM OF APE1 ASP148GLU IS NOT ASSOCIATED WITH BLADDER CANCER RISK IN A TURKISH POPULATION

Öz:

Objective: The purpose of this investigative research was to investigate the potential impact of a single nucleotide polymorphism (Asp148Glu) within the APE1 gene on the development of bladder cancer (BCa) and spread, and to investigate the interaction of this polymorphism with cigarette smoking in BCa patients. Materials and Methods: In a study of 256 participants, consisting of 136 healthy individuals and 120 patients with BCa, the APE1 Asp148Glu polymorphism was evaluated using “polymerase chain reaction restriction- fragment length polymorphism” analysis. Results: There were no noteworthy difference variations observed in genotype distribution between the group of individuals with BCa and the control group with regards to the APE1 gene polymorphism. Furthermore, the APE1 gene polymorphism exhibited no correlation with the clinicopathological characteristics or smoking habits of individuals with BCa. Conclusion: Based on our findings, it appears that the APE1 gene polymorphism, which plays a role in the BER pathway, does not appear to be a contributing factor in susceptibility to BCa in the Turkish population. In addition, the smoking habit may not modify BCa risk with respect to genetic variations in the APE1 gene.

Anahtar Kelime:

TÜRK POPÜLASYONUNDA APE1 ASP148GLU GEN POLİMORFİZMİNİN MESANE KANSERİ İLE İLİŞKİSİ BULUNMAMAKTADIR

Öz:

Amaç: Çalışmamızda, APE1 (Asp148Glu) gen polimorfizmi ile mesane kanseri oluşumu ve gelişimi arasındaki ilişkiyi araştırmayı amaçladık. Ayrıca, mesane kanserinde sigara kullanımı ile APE 1 gen polimorfizmi arasındaki ilişkiyi değerlendirmeyi planladık. Gereç ve yöntem: Çalışmamızda histopatolojik ve klinik açıdan mesane kanseri tanısı konan hastalar (n=120) ve sağlıklı normal kişiler (n=136) yer aldı. Çalışma grubundaki kişilerden elde edilen DNA’lardan Apürinik/ Aprimidinik Endonükleaz 1 (APE1) gen polimorfizmi için polimeraz zincir reaksiyonu (PZR), sınırlayıcı enzim parça uzunluğu polimorfizmi (RFLP) teknikleri kullanıldı. Bulgular: APE1 gen polimorfizminde genotip ve allel sıklığı incelendiğinde mesane kanseri ve kontrol grubu arasında anlamlı farklılık bulunmamakta- dır. İlaveten, yüksek grade, ileri evre ve sigara kullanımı bakımından da incelendiğinde anlamlı bir faklılık bulunmamaktadır. Sonuç: APE 1 gen polimorfizminin mesane kanseri oluşumunda ve gelişi- minde bir risk içermediğini ayrıca, sigara kullanımının APE Asp148Glu gen polimorfizminde etkili olmadığını ileri sürebiliriz.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	RENDI T, Kılınç S, Erdem S, Değirmenci E, Sanli O, KUCUKGERGIN C, Dogru-Abbasoglu S (2023). GENETIC POLYMORPHISM OF APE1 ASP148GLU IS NOT ASSOCIATED WITH BLADDER CANCER RISK IN A TURKISH POPULATION. , 117 - 121. 10.26650/JARHS2023-1273011
Chicago	RENDI TAGHI AHMADI,Kılınç Serhat,Erdem Selcuk,Değirmenci Enes,Sanli Oner,KUCUKGERGIN CANAN,Dogru-Abbasoglu Semra GENETIC POLYMORPHISM OF APE1 ASP148GLU IS NOT ASSOCIATED WITH BLADDER CANCER RISK IN A TURKISH POPULATION. (2023): 117 - 121. 10.26650/JARHS2023-1273011
MLA	RENDI TAGHI AHMADI,Kılınç Serhat,Erdem Selcuk,Değirmenci Enes,Sanli Oner,KUCUKGERGIN CANAN,Dogru-Abbasoglu Semra GENETIC POLYMORPHISM OF APE1 ASP148GLU IS NOT ASSOCIATED WITH BLADDER CANCER RISK IN A TURKISH POPULATION. , 2023, ss.117 - 121. 10.26650/JARHS2023-1273011
AMA	RENDI T,Kılınç S,Erdem S,Değirmenci E,Sanli O,KUCUKGERGIN C,Dogru-Abbasoglu S GENETIC POLYMORPHISM OF APE1 ASP148GLU IS NOT ASSOCIATED WITH BLADDER CANCER RISK IN A TURKISH POPULATION. . 2023; 117 - 121. 10.26650/JARHS2023-1273011
Vancouver	RENDI T,Kılınç S,Erdem S,Değirmenci E,Sanli O,KUCUKGERGIN C,Dogru-Abbasoglu S GENETIC POLYMORPHISM OF APE1 ASP148GLU IS NOT ASSOCIATED WITH BLADDER CANCER RISK IN A TURKISH POPULATION. . 2023; 117 - 121. 10.26650/JARHS2023-1273011
IEEE	RENDI T,Kılınç S,Erdem S,Değirmenci E,Sanli O,KUCUKGERGIN C,Dogru-Abbasoglu S "GENETIC POLYMORPHISM OF APE1 ASP148GLU IS NOT ASSOCIATED WITH BLADDER CANCER RISK IN A TURKISH POPULATION." , ss.117 - 121, 2023. 10.26650/JARHS2023-1273011
ISNAD	RENDI, TAGHI AHMADI vd. "GENETIC POLYMORPHISM OF APE1 ASP148GLU IS NOT ASSOCIATED WITH BLADDER CANCER RISK IN A TURKISH POPULATION". (2023), 117-121. https://doi.org/10.26650/JARHS2023-1273011

APA	RENDI T, Kılınç S, Erdem S, Değirmenci E, Sanli O, KUCUKGERGIN C, Dogru-Abbasoglu S (2023). GENETIC POLYMORPHISM OF APE1 ASP148GLU IS NOT ASSOCIATED WITH BLADDER CANCER RISK IN A TURKISH POPULATION. Sabiad , 6(2), 117 - 121. 10.26650/JARHS2023-1273011
Chicago	RENDI TAGHI AHMADI,Kılınç Serhat,Erdem Selcuk,Değirmenci Enes,Sanli Oner,KUCUKGERGIN CANAN,Dogru-Abbasoglu Semra GENETIC POLYMORPHISM OF APE1 ASP148GLU IS NOT ASSOCIATED WITH BLADDER CANCER RISK IN A TURKISH POPULATION. Sabiad 6, no.2 (2023): 117 - 121. 10.26650/JARHS2023-1273011
MLA	RENDI TAGHI AHMADI,Kılınç Serhat,Erdem Selcuk,Değirmenci Enes,Sanli Oner,KUCUKGERGIN CANAN,Dogru-Abbasoglu Semra GENETIC POLYMORPHISM OF APE1 ASP148GLU IS NOT ASSOCIATED WITH BLADDER CANCER RISK IN A TURKISH POPULATION. Sabiad , vol.6, no.2, 2023, ss.117 - 121. 10.26650/JARHS2023-1273011
AMA	RENDI T,Kılınç S,Erdem S,Değirmenci E,Sanli O,KUCUKGERGIN C,Dogru-Abbasoglu S GENETIC POLYMORPHISM OF APE1 ASP148GLU IS NOT ASSOCIATED WITH BLADDER CANCER RISK IN A TURKISH POPULATION. Sabiad . 2023; 6(2): 117 - 121. 10.26650/JARHS2023-1273011
Vancouver	RENDI T,Kılınç S,Erdem S,Değirmenci E,Sanli O,KUCUKGERGIN C,Dogru-Abbasoglu S GENETIC POLYMORPHISM OF APE1 ASP148GLU IS NOT ASSOCIATED WITH BLADDER CANCER RISK IN A TURKISH POPULATION. Sabiad . 2023; 6(2): 117 - 121. 10.26650/JARHS2023-1273011
IEEE	RENDI T,Kılınç S,Erdem S,Değirmenci E,Sanli O,KUCUKGERGIN C,Dogru-Abbasoglu S "GENETIC POLYMORPHISM OF APE1 ASP148GLU IS NOT ASSOCIATED WITH BLADDER CANCER RISK IN A TURKISH POPULATION." Sabiad , 6, ss.117 - 121, 2023. 10.26650/JARHS2023-1273011
ISNAD	RENDI, TAGHI AHMADI vd. "GENETIC POLYMORPHISM OF APE1 ASP148GLU IS NOT ASSOCIATED WITH BLADDER CANCER RISK IN A TURKISH POPULATION". Sabiad 6/2 (2023), 117-121. https://doi.org/10.26650/JARHS2023-1273011