TY  - JOUR
TI  - Can pirfenidone prevent tendon adhesions? An experimental study in rats
AB  - Objectives: In this experimental study, we aimed to investigate the effectiveness of oral pirfenidone (PFD) treatment on preventing tendon adhesion and tendon healing in rats. Materials and methods: A total of 21 rats were assigned into three groups including seven rats in each group. In Group 1 (sham group), no surgical procedure was performed. In Group 2 (control group), tendon repair was performed following right achillotomy. In Group 3 (treatment group), the rats also underwent tendon repair after right achillotomy. Additionally, 30 mg/kg of oral PFD was initiated from the postoperative Day 1 and administered via gavage for 28 days. At the end of the study, tendon healing and fibrosis levels in the tendon repair site were compared macroscopically, histopathologically, and immunohistochemically among the groups. Results: Macroscopically, moderate and severe adhesions were observed in four and three rats, respectively in the control group, while no adhesion was found in four rats and filmy adhesions were observed in three rats in the treatment group (p<0.01). Microscopically, there was moderate adhesions in three rats and severe adhesions in four rats in the control group, while three rats had no adhesions and four rats had slight adhesions in the treatment group (p<0.01). Microscopically, tendon healing was good in six rats and fair in one rat in the control group, while five rats showed excellent tendon healing and two rats showed good tendon healing in the treatment group (p<0.01). Immunohistochemically, expressions of collagen I (p<0.01), collagen III (p<0.001), vascular endothelial growth factor (VEGF) (p<0.001), and proliferating cell nuclear antigen (PCNA) (p<0.001) significantly decreased in the treatment group compared to the control group. Conclusion: Our study results indicated that PFD decreased collagen synthesis and prevented the formation of peritendinous adhesion in rats; however, it did not impair tendon healing.
AU  - güven, necip
AU  - İSMALOV, Ulan
AU  - Uyumaz, Mehmet Ali
AU  - Gökalp, Mehmet Ata
AU  - Türközü, Tülin
AU  - altındağ, fikret
AU  - Tokyay, Abbas
AU  - AKKOL, Suna
DO  - 10.52312/jdrs.2023.1012
PY  - 2023
JO  - Joint diseases and related surgery
VL  - 34
IS  - 2
SN  - 2687-4784
SP  - 396
EP  - 404
DB  - TRDizin
UR  - http://search/yayin/detay/1186090
ER  -