TY  - JOUR
TI  - DOCK8 deficiency with hypereosinophilia and the syndrome of inappropriate antidiuretic hormone secretion during herpes infection
AB  - Background. Hyperimmunoglobulin E syndrome (HIES) due to dedicator of cytokinesis8 (DOCK8) deficiency may present in infancy and childhood with different clinical features involving recurrent infections, allergic dysregulation, and autoimmunity. Case. In this report, we describe a patient who first presented with severe hypereosinophilia and went on to develop the syndrome of inappropriate antidiuretic hormone secretion (SIADH) in the context of a severe herpes infection. Investigation revealed the presence of underlying DOCK8 deficiency presenting with atypical clinical features. Conclusions. Distinct inflammatory features associated with infections may be seen in the course of primary immunodeficiency diseases, and early functional and molecular genetic tests will aid the proper management.
AU  - Gül, Ersin
AU  - Gonc, E. Nazli
AU  - Tezcan, İlhan
AU  - Gursel, Mayda
AU  - Kayaoğlu, Başak
AU  - Çağdaş, Deniz
AU  - Özön, Z. Alev
AU  - Mete Yesil, Ayse
DO  - 10.24953/turkjped.2020.1934
PY  - 2023
JO  - Turkish Journal of Pediatrics
VL  - 65
IS  - 3
SN  - 0041-4301
SP  - 536
EP  - 541
DB  - TRDizin
UR  - http://search/yayin/detay/1186369
ER  -