Kedi ve Köpek Hastalıklarının Tedavisinde Mezenkimal Kök Hücre Uygulamaları

UYURCA, Sare; Meral, Öğünç

Kedi ve Köpek Hastalıklarının Tedavisinde Mezenkimal Kök Hücre Uygulamaları

Sare UYURCA, (Ankara Üniversitesi, Veteriner Fakültesi, Biyokimya Ana Bilim Dalı, Ankara, Türkiye)

Öğünç MERAL (Ankara Üniversitesi, Veteriner Fakültesi, Biyokimya Ana Bilim Dalı, Ankara, Türkiye)

Fırat Üniversitesi Sağlık Bilimleri Veteriner Dergisi

14 6

Yıl: 2023 Cilt: 37 Sayı: 2 Sayfa Aralığı: 160 - 167 Metin Dili: Türkçe İndeks Tarihi: 20-07-2023

Kedi ve Köpek Hastalıklarının Tedavisinde Mezenkimal Kök Hücre Uygulamaları

Öz:

İnsan ve hayvan vücudu hemen hemen her doku tipinde bulunan kök hücreler aracılığıyla endojen bir rejenerasyon sistemine sahiptir. Kök hücreler kendini yenileme, çeşitli hücre soylarına çoğalma ve farklılaşma yeteneğine sahip hücrelerdir. Veteriner hekimlikte kök hücre çalışmaları hem deneysel hem de klinik olarak hızla gelişmeye devam etmektedir. Günümüzde kök hücreler göz, karaciğer, böbrek, kalp, kas-iskelet, nörolojik, dermatolojik, solunum ve sindirim sistemi hastalıklarının tedavisinde kullanılmaya başlanmıştır. Kök hücre biyolojisindeki son gelişmeler, tedavi edilemeyen hastalıkların sağaltımında yeni bakış açıları kazandırmıştır. Veteriner hekimlik alanında kök hücre tedavisi göz hastalıkları, dermatolojik hastalıklar, kas-iskelet sistemi hastalıkları ve nörodejeneratif hastalıklar başta olmak üzere birçok alanda umut verici sonuçlar sağlamıştır. Kök hücre tedavisinde yaşanan önemli gelişmeler yanında bu alanın yeni tedavi stratejileri geliştirme potansiyeline sahip olduğu ve bu alanda yeni çalışmalara ihtiyaç duyulduğu düşünülmektedir.

Anahtar Kelime: Mezenkimal kök hücre kök hücre tedavisi rejeneratif tıp

Applications of Mesenchymal Stem Cells for Treatment of Cats and Dogs Diseases

Öz:

The human and animal bodies have an endogenous regeneration system through stem cells that are found in almost every tissue type. Stem cells have the ability to self-renewal, proliferation and differentiation into various cells. Stem cell studies in veterinary medicine continue to develop rapidly, both experimentally and clinically. Recently, stem cells have been used in the treatment of eye, liver, kidney, heart, musculoskeletal, neurological, dermatological, respiratory and digestive system diseases. Recent developments in stem cell biology have provided new perspectives in the treatment of incurable diseases. Stem cell therapy has provided promising results to treat several types of diseases, such as eye diseases, dermatological diseases, musculoskeletal diseases and neurodegenerative diseases in veterinary medicine. In addition to the great developments in stem cell therapy, it is thought that this field has the potential to develop new treatment strategies and therefore further studies are needed in this area.

Anahtar Kelime: Mesenchymal stem cell stem cell therapy regenerative medicine

Belge Türü: Makale Makale Türü: Derleme Erişim Türü: Erişime Açık

1. Kolios G, Moodley Y. Introduction to stem cells and regenerative medicine. Respiration 2013; 85: 3-10.
2. Weissman IL, Anderson DJ, Gage F. Stem and progenitor cells: Origins, phenotypes, lineage commitments, and transdifferentiations. Annu Rev Cell Dev Biol 2001; 17: 387-403.
3. Ullah I, Subbarao RB, Rho GJ. Human mesenchymal stem cells - current trends and future prospective. Biosci Rep 2015; 35: e00191.
4. Gomes IS, Oliveira VC, Pinheiro AO, et al. Bone marrow stem cell applied in the canine veterinary clinics. Pesq Vet Bras 2017; 37: 1139-1145.
5. Song L, Tuan RS. Transdifferentiation potential of human mesenchymal stem cells derived from bone marrow. FASEB J 2004; 18: 980-982.
6. Harman RJ. Stem cell therapy in veterinary dermatology. Vet Dermatol 2013; 24: 90-e24.
7. Quimby JM, Dow SW. Novel treatment strategies for feline chronic kidney disease: A critical look at the potential of mesenchymal stem cell therapy. Vet J 2015; 204: 241-246.
8. Volk SW, Theoret C. Translating stem cell therapies: The role of companion animals in regenerative medicine. Wound Repair Regen 2013; 21: 382-394.
9. Prządka P, Buczak K, Frejlich E, et al. The role of mesenchymal stem cells (MSCs) in veterinary medicine and their use in musculoskeletal disorders. Biomolecules 2021; 11: 1141.
10. Brondeel C, Pauwelyn G, de Bakker E, et al. Review: Mesenchymal stem cell therapy in canine osteoarthritis research: "experientia docet" (experience will teach us). Front Vet Sci 2021; 8: 668881.
11. Dias IE, Pinto PO, Barros LC, et al. Mesenchymal stem cells therapy in companion animals: useful for immune- mediated diseases? BMC Vet Res 2019; 15: 358.
12. Reichert CO, de Freitas FA, Levy D, Bydlowski SP. Oxysterols and mesenchymal stem cell biology. Vitam Horm 2021; 116: 409-436.
13. Villatoro AJ, Claros S, Fernandez V, et al. Safety and efficacy of the mesenchymal stem cell in feline eosinophilic keratitis treatment. BMC Vet Res 2018; 14: 116.
14. Arantes-Tsuzuki PDM, Mazzonetto PC, Lo Turco EG. Treatment for canine corneal ulcer using adipose tissue derived mesenchymal stem cell therapy-Case report. Preprints 2019; 2019: 120185.
15. Bittencourt MKW, Barros MA, Martins JFP, et al. Allogeneic mesenchymal stem cell transplantation in dogs with keratoconjunctivitis sicca. Cell Med 2016; 8: 63-77.
16. Sgrignoli MR, Silva DA, Nascimento FF, et al. Reduction in the inflammatory markers CD4, IL-1, IL-6 and TNF in dogs with keratoconjunctivitis sicca treated topically with mesenchymal stem cells. Stem Cell Res 2019; 39: 101525.
17. Zubin E, Conti V, Leonardi F, et al. Regenerative therapy for the management of a large skin wound in a dog. Clin Case Rep 2015; 3: 598-603.
18. Kim JW, Lee JH, Lyoo YS, Jung DI, Park HM. The effects of topical mesenchymal stem cell transplantation in canine experimental cutaneous wounds. Vet Dermatol 2013; 24: 242-e53.
19. Ribeiro J, Pereira T, Amorim I, et al. Cell therapy with human MSCs isolated from the umbilical cord Wharton jelly associated to a PVA membrane in the treatment of chronic skin wounds. Int J Med Sci 2014; 11: 979-987.
20. Nanjappa MD, Ahmad RA, Amarpal, et al. Caudal superficial epigastric axial pattern flap and stem cell therapy for the management of large wound on medial aspect of thigh in a dog. Adv Anim Vet Sci 2014; 2: 188- 191.
21. Hall MN, Rosenkrantz WS, Hong JH, Griffin CE, Mendelsohn CM. Evaluation of the potential use of adipose-derived mesenchymal stromal cells in the treatment of canine atopic dermatitis: A pilot study. Vet Ther 2010; 11: E1-E14.
22. Villatoro AJ, Hermida-Prieto M, Fern ndez V, et al. Allogeneic adipose-derived mesenchymal stem cell therapy in dogs with refractory atopic dermatitis: Clinical efficacy and safety. Vet Rec 2018; 183: 654.
23. Nishimura T, Takami T, Sasaki R, et al. Liver regeneration therapy through the hepatic artery-infusion of cultured bone marrow cells in a canine liver fibrosis model. PLoS One 2019; 14: e0210588.
24. Matsuda T, Takami T, Sasaki R, et al. A canine liver fibrosis model to develop a therapy for liver cirrhosis using cultured bone marrow–derived cells. Hepatol Commun 2017; 1: 691–703.
25. Yan Y, Fang J, Wen X, et al. Therapeutic applications of adipose-derived mesenchymal stem cells on acute liver injury in canines. Res Vet Sci 2019; 126: 233-239.
26. Nam A, Han SM, Go DM, et al. Long-term management with adipose tissue-derived mesenchymal stem cells and conventional treatment in a dog with Hepatocutaneous syndrome. J Vet Intern Med 2017; 31: 1514-1519.
27. Vikartovska Z, Humenik F, Maloveska M, et al. Adult stem cells based therapies in veterinary medicine. Arch Vet Sci Med 2020; 3: 40-50.
28. Edaso T, Kebede A. Review on applications of stem cells in veterinary therapeutic practices. ARC J Anim Vet Sci 2018; 4: 20-32.
29. Taghavi S, Sharp TE, Duran JM, et al. Autologous c-kit+ mesenchymal stem cell injections provide superior therapeutic benefit as compared to c-kit+ cardiac-derived stem cells in a feline model of isoproterenol-induced cardiomyopathy. Clin Transl Sci 2015; 8: 425-431.
30. Sousa MG, Paulino-Junior D, Pascon JPE, et al. Cardiac function in dogs with chronic Chagas cardiomyopathy undergoing autologous stem cell transplantation into the coronary arteries. Can Vet J 2011; 52: 869-874.
31. Petchdee S, Sompeewong S. Intravenous administration of puppy deciduous teeth stem cells in degenerative valve disease. Vet World 2016; 9: 1429-1434.
32. Pogue B, Estrada AH, Sosa-Samper I, et al. Stem-cell therapy for dilated cardiomyopathy: A pilot study evaluating retrograde coronary venous delivery. J Small Anim Pract 2013; 54: 361–366.
33. Hensley MT, Tang J, Woodruff K, et al. Intracoronary allogeneic cardiosphere-derived stem cells are safe for use in dogs with dilated cardiomyopathy. J Cell Mol Med 2017; 21: 1503-1512.
34. Voga M, Adamic N, Vengust M, Majdic G. Stem cells in veterinary medicine-current state and treatment options. Front Vet Sci 2020; 7: 278.
35. P rez-Merino EM, Uson-Casaus JM, Duque-Carrasco J, et al. Safety and efficacy of allogeneic adipose tissue- derived mesenchymal stem cells for treatment of dogs with inflammatory bowel disease: Endoscopic and histological outcomes. Vet J 2015; 206: 391-397.
36. P rez-Merino EM, Uson-Casaus JM, Zaragoza-Bayle C, et al. Safety and efficacy of allogeneic adipose tissue- derived mesenchymal stem cells for treatment of dogs with inflammatory bowel disease: Clinical and laboratory outcomes. Vet J 2015; 206: 385-390.
37. Arzi B, Mills-Ko E, Verstraete FJ, et al. Therapeutic efficacy of fresh, autologous mesenchymal stem cells for severe refractory gingivostomatitis in cats. Stem Cells Transl Med 2016; 5: 75-86.
38. Arzi B, Clark KC, Sundaram A, et al. Therapeutic efficacy of fresh, allogeneic mesenchymal stem cells for severe refractory feline chronic gingivostomatitis. Stem Cells Transl Med 2017; 6: 1710-1722.
39. Webb TL, Webb CB. Stem cell therapy in cats with chronic enteropathy: a proof-of-concept study. J Feline Med Surg 2015; 17: 901-908.
40. Ferrer L, Kimbrel EA, Lam A, et al. Treatment of perianal fistulas with human embryonic stem cell-derived mesenchymal stem cells: a canine model of human fistulizing Crohn’s disease. Regen Med 2016; 11: 33-43.
41. Trzil JE, Masseau I, Webb TL, et al. Long term evaluation of mesenchymal stem cell therapy in a feline model of chronic allergic asthma. Clin Exp Allergy 2014; 44: 1546-1557.
42. Trzil JE, Masseau I, Webb TL, et al. Intravenous adipose- derived mesenchymal stem cell therapy for the treatment of feline asthma: A pilot study. J Feline Med Surg 2016; 18: 981-990.
43. Quimby JM, Webb TL, Habenicht LM, Dow SW. Safety and efficacy of intravenous infusion of allogeneic cryopreserved mesenchymal stem cells for treatment of chronic kidney disease in cats: Results of three sequential pilot studies. Stem Cell Res Ther 2013; 4: 48.
44. Rosselli DD, Mumaw JL, Dickerson V, et al. Efficacy of allogeneic mesenchymal stem cell administration in a model of acute ischemic kidney injury in cats. Res Vet Sci 2016; 108: 18-24.
45. Lee SJ, Ryu MO, Seo MS, et al. Mesenchymal stem cells contribute to improvement of renal function in a canine kidney injury model. In Vivo 2017; 31: 1115-1124.
46. Quimby JM, Webb TL, Gibbons DS, Dow SW. Evaluation of intrarenal mesenchymal stem cell injection for treatment of chronic kidney disease in cats: a pilot study. J Feline Med Surg 2011; 13: 418-426.
47. Quimby JM, Webb TL, Randall E, et al. Assessment of intravenous adipose-derived allogeneic mesenchymal stem cells for the treatment of feline chronic kidney disease: a randomized, placebo-controlled clinical trial in eight cats. J Feline Med Surg 2016; 18: 165-171.
48. Vidane AS, Pinheiro AO, Casals JB, et al. Transplantation of amniotic membrane-derived multipotent cells ameliorates and delays the progression of chronic kidney disease in cats. Reprod Domest Anim 2017; 52: 316-326.
49. Malakar D, Malik HN, Kumar D, et al. Advances in Animal Genomics. In: Mondal S, Singh RL. (Editors). Stem Cells: A Potential Regenerative Medicine for Treatment of Diseases. 1st Edition, Academic Press 2021: 33-48.
50. Shah K, Drury T, Roic I, et al. Outcome of allogeneic adult stem cell therapy in dogs suffering from osteoarthritis and other joint defects. Stem Cells Int 2018; 2018: 7309201.
51. Yoon HY, Lee JH, Jeong SW. Long-term follow-up after implantation of autologous adipose tissue derived mesenchymal stem cells to treat a dog with stifle joint osteoarthrosis. J Vet Clin 2012; 29: 82-86.
52. Cabon Q, Febre M, Gomez N, et al. Long-term safety and efficacy of single or repeated intra-articular injection of allogeneic neonatal Mesenchymal stromal cells for managing pain and lameness in moderate to severe canine osteoarthritis without anti-inflammatory pharmacological support: pilot clinical study. Front Vet Sci 2019; 6: 10.
53. Black LL, Gaynor J, Adams C, et al. Effect of intraarticular injection of autologous adipose-derived mesenchymal stem and regenerative cells on clinical signs of chronic osteoarthritis of the elbow joint in dogs. Vet Ther 2008; 9: 192-200.
54. Cuervo B, Rubio M, Sopena J, et al. Hip osteoarthritis in dogs: A randomized study using Mesenchymal stem cells from adipose tissue and plasma rich in growth factors. Int J Mol Sci 2014; 15: 13437-13460.
55. Kr ston-P l , Cz bula , Gyur s , et al. Character zat on and therapeutic application of canine adipose mesenchymal stem cells to treat elbow osteoarthritis. Can J Vet Res 2017; 81: 73-78.
56. Muir P, Hans EC, Racette M, et al. Autologous bone marrow-derived Mesenchymal stem cells modulate molecular markers of inflammation in dogs with cruciate ligament rupture. PLoS One 2016; 11: e0159095.
57. Rocha Dos Santos C, Da Rocha Filgueiras R, Furtado Malard P, et al. Mesenchymal stem cells in osteotomy repair after tibial tuberosity advancement in dogs with cranial cruciate ligament injury. J Exp Orthop 2018; 5: 17.
58. Lee HB, Chung YS, Heo SY, Kim NS. Augmentation of bone healing of nonunion fracture using stem cell based tissue engineering in a dog: a case report. Vet Med 2009; 54: 198-203.
59. Song J, Kim Y, Kweon OK, Kang BJ. Use of stem-cell sheets expressing bone morphogenetic protein-7 in the management of a nonunion radial fracture in a toy poodle. J Vet Sci 2017; 18: 555-558.
60. Brown SG, Harman RJ, Black LL. Adipose-derived stem cell therapy for severe muscle tears in working German shepherds: Two case reports. Stem Cell Discov 2012; 2: 41-44.
61. Kang MH, Park HM. Challenges of stem cell therapies in companion animal practice. J Vet Sci 2020; 21: e42.
62. Ryu HH, Kang BJ, Park SS, et al. Comparison of mesenchymal stem cells derived from fat, bone marrow, wharton’s jelly, and umbilical cord blood for treating spinal cord injuries in dogs. J Vet Med Sci 2012; 74: 1617-1630.
63. Kim Y, Jo SH, Kim WH, Kweon OK. Antioxidant and anti- inflammatory effects of intravenously injected adipose derived mesenchymal stem cells in dogs with acute spinal cord injury. Stem Cell Res Ther 2015; 6: 229.
64. Granger N, Blamires H, Franklin RJM, Jeffery ND. Autologous olfactory mucosal cell transplants in clinical spinal cord injury: A randomized double-blinded trial in a canine translational model. Brain 2012; 135: 3227-3237.
65. Nishida H, Nakayama M, Tanaka H, et al. Evaluation of transplantation of autologous bone marrow stromal cells into the cerebrospinal fluid for treatment of chronic spinal cord injury in dogs. Am J Vet Res 2011; 72: 1118-1123.
66. Sarmento CAP, Rodrigues MN, Bocabello RZ, Mess AM, Miglino MA. Pilot study: bone marrow stem cells as a treatment for dogs with chronic spinal cord injury. Regen Med Res 2014; 2: 9.
67. Escalh o CCM, Ramos IP, Hochman-Mendez C, et al. Safety of allogeneic canine adipose tissue-derived Mesenchymal stem cell intraspinal transplantation in dogs with chronic spinal cord injury. Stem Cells Int 2017; 2017: 3053759.
68. Hiyama A, Mochida J, Iwashina T, et al. Transplantation of mesenchymal stem cells in a canine disc degeneration model. J Orthop Res 2008; 26: 589-600.
69. Penha EM, Me ra CS, Gu mar es ET, et al. Use of autologous mesenchymal stem cells derived from bone marrow for the treatment of naturally injured spinal cord in dogs. Stem Cells Int 2014; 2014: 437521.
70. Beşaltı O, Can P, Akpınar E, et al. Intraspinal transplantation of autologous neurogenically-induced bone marrow-derived mesenchymal stem cells in the treatment of paraplegic dogs without deep pain perception secondary to intervertebral disk disease. Turk Neurosurg 2015; 25: 625-632.
71. Zeira O, Asiag N, Aralla M, et al. Adult autologous mesenchymal stem cells for the treatment of suspected non-infectious inflammatory diseases of the canine central nervous system: Safety, feasibility and preliminary clinical findings. J Neuroinflammation 2015; 12: 181.
72. Pinheiro AO, Cardoso MT, Vidane AS, et al. Controversial results of therapy with mesenchymal stem cells in the acute phase of canine distemper disease. Genet Mol Res 2016; 15: 8310.
73. Pinheiro LL, De Lima AR, Martins DM, et al. Mesenchymal stem cells in dogs with demyelinating leukoencephalitis as an experimental model of multiple sclerosis. Heliyon 2019; 5: e01857.

APA	UYURCA S, Meral Ö (2023). Kedi ve Köpek Hastalıklarının Tedavisinde Mezenkimal Kök Hücre Uygulamaları. , 160 - 167.
Chicago	UYURCA Sare,Meral Öğünç Kedi ve Köpek Hastalıklarının Tedavisinde Mezenkimal Kök Hücre Uygulamaları. (2023): 160 - 167.
MLA	UYURCA Sare,Meral Öğünç Kedi ve Köpek Hastalıklarının Tedavisinde Mezenkimal Kök Hücre Uygulamaları. , 2023, ss.160 - 167.
AMA	UYURCA S,Meral Ö Kedi ve Köpek Hastalıklarının Tedavisinde Mezenkimal Kök Hücre Uygulamaları. . 2023; 160 - 167.
Vancouver	UYURCA S,Meral Ö Kedi ve Köpek Hastalıklarının Tedavisinde Mezenkimal Kök Hücre Uygulamaları. . 2023; 160 - 167.
IEEE	UYURCA S,Meral Ö "Kedi ve Köpek Hastalıklarının Tedavisinde Mezenkimal Kök Hücre Uygulamaları." , ss.160 - 167, 2023.
ISNAD	UYURCA, Sare - Meral, Öğünç. "Kedi ve Köpek Hastalıklarının Tedavisinde Mezenkimal Kök Hücre Uygulamaları". (2023), 160-167.

APA	UYURCA S, Meral Ö (2023). Kedi ve Köpek Hastalıklarının Tedavisinde Mezenkimal Kök Hücre Uygulamaları. Fırat Üniversitesi Sağlık Bilimleri Veteriner Dergisi, 37(2), 160 - 167.
Chicago	UYURCA Sare,Meral Öğünç Kedi ve Köpek Hastalıklarının Tedavisinde Mezenkimal Kök Hücre Uygulamaları. Fırat Üniversitesi Sağlık Bilimleri Veteriner Dergisi 37, no.2 (2023): 160 - 167.
MLA	UYURCA Sare,Meral Öğünç Kedi ve Köpek Hastalıklarının Tedavisinde Mezenkimal Kök Hücre Uygulamaları. Fırat Üniversitesi Sağlık Bilimleri Veteriner Dergisi, vol.37, no.2, 2023, ss.160 - 167.
AMA	UYURCA S,Meral Ö Kedi ve Köpek Hastalıklarının Tedavisinde Mezenkimal Kök Hücre Uygulamaları. Fırat Üniversitesi Sağlık Bilimleri Veteriner Dergisi. 2023; 37(2): 160 - 167.
Vancouver	UYURCA S,Meral Ö Kedi ve Köpek Hastalıklarının Tedavisinde Mezenkimal Kök Hücre Uygulamaları. Fırat Üniversitesi Sağlık Bilimleri Veteriner Dergisi. 2023; 37(2): 160 - 167.
IEEE	UYURCA S,Meral Ö "Kedi ve Köpek Hastalıklarının Tedavisinde Mezenkimal Kök Hücre Uygulamaları." Fırat Üniversitesi Sağlık Bilimleri Veteriner Dergisi, 37, ss.160 - 167, 2023.
ISNAD	UYURCA, Sare - Meral, Öğünç. "Kedi ve Köpek Hastalıklarının Tedavisinde Mezenkimal Kök Hücre Uygulamaları". Fırat Üniversitesi Sağlık Bilimleri Veteriner Dergisi 37/2 (2023), 160-167.