Nicotinamide Riboside Preserves Ovarian Injury in an Experimental  Sepsis Model in Rats

selli, jale; keleş, osman nuri; YETİM, Zeliha; DİLEK, VURAL KELEŞ; ÇELİK, Muhammet

doi:10.5152/eurasianjmed.2023.22255

Nicotinamide Riboside Preserves Ovarian Injury in an Experimental Sepsis Model in Rats

Jale SELLİ, (Alanya Alaaddin Keykubat Üniversitesi, Fen Fakültesi, Tıp, Histoloji ve Embriyoloji Bölümü, Antalya, Türkiye)

VURAL KELEŞ DİLEK, (Kırklareli Üniversitesi, Sağlık Bilimleri Fakültesi, Hemşirelik Bölümü, Kırklareli, Türkiye)

Osman Nuri KELEŞ, (Atatürk Üniversitesi, Tıp Fakültesi, Histoloji ve Embriyoloji Bölümü, Erzurum, Türkiye)

Muhammet ÇELİK, (Atatürk Üniversitesi, Tıp Fakültesi, Tıbbi Biyokimya Anabilim Dalı, Erzurum, Türkiye)

Zeliha YETİM (Sağlık Bilimleri Üniversitesi, Hamidiye Uluslararası Tıp Fakültesi, Histoloji ve Embriyoloji Bölümü, İstanbul, Türkiye)

Eurasian Journal of Medicine

3 1

Yıl: 2023 Cilt: 55 Sayı: 2 Sayfa Aralığı: 128 - 134 Metin Dili: Türkçe DOI: 10.5152/eurasianjmed.2023.22255 İndeks Tarihi: 20-07-2023

Nicotinamide Riboside Preserves Ovarian Injury in an Experimental Sepsis Model in Rats

Öz:

Objective: The aim of the study is to investigate the protective effects of nicotinamide riboside on oxidative stress in an experimental sepsis model created by cecal ligation and puncture. Materials and Methods: Rats were divided into 3 groups randomly: sham-operated (control) group, sep sis group, and nicotinamide riboside-treated group. Sepsis model-induced cecal ligation and puncture was applied to sepsis group rats. Animals in the nicotinamide riboside-treated group were administered nicotin amide riboside intraperitoneally (500 mg/kg). Tissue specimens from rats were biochemically calculated for their activities of catalase, superoxide dismutase, glutathione peroxidase, myeloperoxidase, and malondialde hyde levels. Ovarian tissues of all rats were histopathologically evaluated. Results: Catalase, superoxide dismutase, and glutathione peroxidase activities were lower in the sepsis group compared to the sham-operated (control) group. Superoxide dismutase activity was significantly higher in the nicotinamide riboside-treated group than in control and sepsis group (P < .05). Myeloperoxidase activi ties and mean malondialdehyde concentration of ovarian tissue were lower in nicotinamide riboside-treated group than in sepsis group (P < .05). The light microscopic assessment revealed that ovarian tissue was protected, and inflammation and interstitial edema decreased in nicotinamide riboside-treated group. The follicular damage findings were notably decreased in nicotinamide riboside-treated group in comparison to sepsis group (P<0.05). Conclusion: Our findings indicated that nicotinamide riboside diminished ovarian injury in sepsis via inhibiting tissue infiltration and increasing endogenous antioxidant capacity. Nicotinamide riboside administration may represent a new treatment approach for the prevention of sepsis-induced ovarian injury

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	selli j, DİLEK V, keleş o, ÇELİK M, YETİM Z (2023). Nicotinamide Riboside Preserves Ovarian Injury in an Experimental Sepsis Model in Rats. , 128 - 134. 10.5152/eurasianjmed.2023.22255
Chicago	selli jale,DİLEK VURAL KELEŞ,keleş osman nuri,ÇELİK Muhammet,YETİM Zeliha Nicotinamide Riboside Preserves Ovarian Injury in an Experimental Sepsis Model in Rats. (2023): 128 - 134. 10.5152/eurasianjmed.2023.22255
MLA	selli jale,DİLEK VURAL KELEŞ,keleş osman nuri,ÇELİK Muhammet,YETİM Zeliha Nicotinamide Riboside Preserves Ovarian Injury in an Experimental Sepsis Model in Rats. , 2023, ss.128 - 134. 10.5152/eurasianjmed.2023.22255
AMA	selli j,DİLEK V,keleş o,ÇELİK M,YETİM Z Nicotinamide Riboside Preserves Ovarian Injury in an Experimental Sepsis Model in Rats. . 2023; 128 - 134. 10.5152/eurasianjmed.2023.22255
Vancouver	selli j,DİLEK V,keleş o,ÇELİK M,YETİM Z Nicotinamide Riboside Preserves Ovarian Injury in an Experimental Sepsis Model in Rats. . 2023; 128 - 134. 10.5152/eurasianjmed.2023.22255
IEEE	selli j,DİLEK V,keleş o,ÇELİK M,YETİM Z "Nicotinamide Riboside Preserves Ovarian Injury in an Experimental Sepsis Model in Rats." , ss.128 - 134, 2023. 10.5152/eurasianjmed.2023.22255
ISNAD	selli, jale vd. "Nicotinamide Riboside Preserves Ovarian Injury in an Experimental Sepsis Model in Rats". (2023), 128-134. https://doi.org/10.5152/eurasianjmed.2023.22255

APA	selli j, DİLEK V, keleş o, ÇELİK M, YETİM Z (2023). Nicotinamide Riboside Preserves Ovarian Injury in an Experimental Sepsis Model in Rats. Eurasian Journal of Medicine, 55(2), 128 - 134. 10.5152/eurasianjmed.2023.22255
Chicago	selli jale,DİLEK VURAL KELEŞ,keleş osman nuri,ÇELİK Muhammet,YETİM Zeliha Nicotinamide Riboside Preserves Ovarian Injury in an Experimental Sepsis Model in Rats. Eurasian Journal of Medicine 55, no.2 (2023): 128 - 134. 10.5152/eurasianjmed.2023.22255
MLA	selli jale,DİLEK VURAL KELEŞ,keleş osman nuri,ÇELİK Muhammet,YETİM Zeliha Nicotinamide Riboside Preserves Ovarian Injury in an Experimental Sepsis Model in Rats. Eurasian Journal of Medicine, vol.55, no.2, 2023, ss.128 - 134. 10.5152/eurasianjmed.2023.22255
AMA	selli j,DİLEK V,keleş o,ÇELİK M,YETİM Z Nicotinamide Riboside Preserves Ovarian Injury in an Experimental Sepsis Model in Rats. Eurasian Journal of Medicine. 2023; 55(2): 128 - 134. 10.5152/eurasianjmed.2023.22255
Vancouver	selli j,DİLEK V,keleş o,ÇELİK M,YETİM Z Nicotinamide Riboside Preserves Ovarian Injury in an Experimental Sepsis Model in Rats. Eurasian Journal of Medicine. 2023; 55(2): 128 - 134. 10.5152/eurasianjmed.2023.22255
IEEE	selli j,DİLEK V,keleş o,ÇELİK M,YETİM Z "Nicotinamide Riboside Preserves Ovarian Injury in an Experimental Sepsis Model in Rats." Eurasian Journal of Medicine, 55, ss.128 - 134, 2023. 10.5152/eurasianjmed.2023.22255
ISNAD	selli, jale vd. "Nicotinamide Riboside Preserves Ovarian Injury in an Experimental Sepsis Model in Rats". Eurasian Journal of Medicine 55/2 (2023), 128-134. https://doi.org/10.5152/eurasianjmed.2023.22255