TY  - JOUR
TI  - Parameters Predicting Microvascular Invasion and Poor Differentiation in Hepatocellular Carcinoma Patients with Normal Alpha-fetoprotein Level Before Liver Transplantation
AB  - Background/Aims: The aim of this study is to evaluate the parameters that might be associated with pathologically diagnosed micro- vascular invasion and poor differentiation, using complete blood count and routine clinical biochemistry test results, in hepatocellular carcinoma patients before liver transplantation. Materials and Methods: The data of patients who underwent liver transplantation for hepatocellular carcinoma at our institute, between March 2006 and November 2021, was researched retrospectively. Results: The incidence of microvascular invasion was 28.6%, poor differentiation rate was 9.3%, hepatocellular carcinoma recurrence rate after liver transplantation was 12.1%, and median time to recurrence was 13 months, in the patients with normal alpha-fetoprotein levels. After univariate and multivariate analysis, maximum tumor diameter >4.5 cm and the number of nodules (n > 5) were found to be independent risk factors for microvascular invasion, and number of nodules >4 and mean platelet volume ≤8.6 fL were found to be independent risk factors for poor differentiation. Serum alpha-fetoprotein levels were still within the normal range at the recurrence time, in 53% of the patients who had recurrence after liver transplantation, but surprisingly were elevated in 47% of the patients at time of hepatocellular carcinoma recurrence. Conclusion: In hepatocellular carcinoma patients with normal alpha-fetoprotein levels before liver transplantation, independent risk factors of the presence of microvascular invasion were maximum tumor diameter and number of nodules, and independent risk factors of poor differentiation were mean platelet volume and number of nodules. Furthermore, serum alpha-fetoprotein levels were still normal at time of recurrence in 53% of hepatocellular carcinoma patients whose alpha-fetoprotein levels were normal before liver transplanta- tion but were elevated in 47% of the patients at recurrence time, despite having normal levels before liver transplantation.
AU  - ince, volkan
AU  - Carr, Brian
AU  - usta, sertaç
AU  - Isik, Burak
AU  - Yilmaz, Sezai
AU  - Kilci, Mahmut Burak
AU  - Samdanci, Emine
AU  - Gozukara Bag, Harika Gozde
DO  - 10.5152/tjg.2023.22538
PY  - 2023
JO  - Turkish Journal of Gastroenterology
VL  - 34
IS  - 7
SN  - 1300-4948
SP  - 753
EP  - 759
DB  - TRDizin
UR  - http://search/yayin/detay/1188044
ER  -