Adrenal cortex regeneration in ethane dimethanesulfonate administered rat model

Gülfidan ÇOŞKUN, (Çukurova Üniversitesi, Tıp Fakültesi, Histoloji ve Embriyoloji Anabilim Dalı, Adana, Türkiye)
Sait POLAT (Çukurova Üniversitesi, Tıp Fakültesi, Histoloji ve Embriyoloji Anabilim Dalı, Adana, Türkiye)
Experimental Biomedical Research
4 0
Yıl: 2023 Cilt: 6 Sayı: 3 Sayfa Aralığı: 181 - 195 Metin Dili: İngilizce DOI: 10.30714/j-ebr.2023.182 İndeks Tarihi: 21-07-2023

Adrenal cortex regeneration in ethane dimethanesulfonate administered rat model

Öz:
Aim: To investigate the parallel morphological and biochemical regeneration of Leydig cells in the adrenal gland after ethane dimethanesulfonate (EDS) administration. Materials and methods: We divided 72 male rats into two groups: the control and EDS groups. Rats in the EDS group received a single dose of EDS (75 mg/kg) intraperitoneally and were sacrificed on days 7, 21, 35, and 63 respectively. Adrenal gland tissue samples obtained from the sacrificed rats were analyzed under light microscopic, immunohistochemical, biochemical, and quantitative methods. Results: In contrast to Caspase-3 expression, 3βHSD and Ki67 expression and thickness of the zona reticularis (ZR) layer and testosterone levels significantly decreased on the 7th, 21st, and 35th days after single-dose EDS. However, 3βHSD and Ki67 expression, testosterone levels, and the ratio of ZR thickness of the EDS group were seen similar to the control group on the 63rd day following EDS administration, but experienced decreasing Caspase-3 expression. After EDS administration, we observed a significant regeneration in the ZR layer of the adrenal gland on the 63rd day. Conclusion: EDS-injected animal models can be used to investigate the development of Leydig cells and assess the turnover of the adrenal cortex (adrenal insufficiency) per time.
Anahtar Kelime:

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APA Coskun G, polat s (2023). Adrenal cortex regeneration in ethane dimethanesulfonate administered rat model. , 181 - 195. 10.30714/j-ebr.2023.182
Chicago Coskun Gulfidan,polat sait Adrenal cortex regeneration in ethane dimethanesulfonate administered rat model. (2023): 181 - 195. 10.30714/j-ebr.2023.182
MLA Coskun Gulfidan,polat sait Adrenal cortex regeneration in ethane dimethanesulfonate administered rat model. , 2023, ss.181 - 195. 10.30714/j-ebr.2023.182
AMA Coskun G,polat s Adrenal cortex regeneration in ethane dimethanesulfonate administered rat model. . 2023; 181 - 195. 10.30714/j-ebr.2023.182
Vancouver Coskun G,polat s Adrenal cortex regeneration in ethane dimethanesulfonate administered rat model. . 2023; 181 - 195. 10.30714/j-ebr.2023.182
IEEE Coskun G,polat s "Adrenal cortex regeneration in ethane dimethanesulfonate administered rat model." , ss.181 - 195, 2023. 10.30714/j-ebr.2023.182
ISNAD Coskun, Gulfidan - polat, sait. "Adrenal cortex regeneration in ethane dimethanesulfonate administered rat model". (2023), 181-195. https://doi.org/10.30714/j-ebr.2023.182
APA Coskun G, polat s (2023). Adrenal cortex regeneration in ethane dimethanesulfonate administered rat model. Experimental Biomedical Research, 6(3), 181 - 195. 10.30714/j-ebr.2023.182
Chicago Coskun Gulfidan,polat sait Adrenal cortex regeneration in ethane dimethanesulfonate administered rat model. Experimental Biomedical Research 6, no.3 (2023): 181 - 195. 10.30714/j-ebr.2023.182
MLA Coskun Gulfidan,polat sait Adrenal cortex regeneration in ethane dimethanesulfonate administered rat model. Experimental Biomedical Research, vol.6, no.3, 2023, ss.181 - 195. 10.30714/j-ebr.2023.182
AMA Coskun G,polat s Adrenal cortex regeneration in ethane dimethanesulfonate administered rat model. Experimental Biomedical Research. 2023; 6(3): 181 - 195. 10.30714/j-ebr.2023.182
Vancouver Coskun G,polat s Adrenal cortex regeneration in ethane dimethanesulfonate administered rat model. Experimental Biomedical Research. 2023; 6(3): 181 - 195. 10.30714/j-ebr.2023.182
IEEE Coskun G,polat s "Adrenal cortex regeneration in ethane dimethanesulfonate administered rat model." Experimental Biomedical Research, 6, ss.181 - 195, 2023. 10.30714/j-ebr.2023.182
ISNAD Coskun, Gulfidan - polat, sait. "Adrenal cortex regeneration in ethane dimethanesulfonate administered rat model". Experimental Biomedical Research 6/3 (2023), 181-195. https://doi.org/10.30714/j-ebr.2023.182
Sayfa Oluşturulma Tarihi
24-04-2024 8:29

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